Evaluation of factors damaging the bronchial wall in lung transplantation

Ruttmann, Elfriede; Ulmer, Hanno; Marchese, Martina; Dunst, Karin M.; Geltner, Christian; Margreiter, Raimund; Laufer, Guenther; Mueller, Ludwig

doi:10.1016/j.healun.2004.01.008

Cited by 72 publications

(57 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Unfortunately, in our study we were not able to look up data on reperfusion edema for the whole cohort because of missing chest X-rays necessary to grade primary graft dysfunction conform the new ISHLT classification. In other studies [14,27,28] AC also resulted in longer intubation periods post-operatively. In our study, we also found a longer duration of mechanical ventilation in patients with AC although the difference did not reach statistical significance.…”

Section: Discussionmentioning

confidence: 73%

“…In a recent report by Ruttmann and co-workers [27] severe reperfusion edema with subsequent longer ventilation time and greater positive end-expiratory pressure, rejection within the first post-operative month, the use of interleukin-2 receptor antibody and interrupted suture technique of the anterior wall were associated with bronchial complications. Reperfusion edema and rejection within the first month remained significant in multivariate analysis.…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Risk factors for airway complications within the first year after lung transplantation

Wauwer

Raemdonck

Verleden

et al. 2007

European Journal of Cardio-Thoracic Surgery

146

View full text Add to dashboard Cite

Objective: Lung transplantation (LTx) has enjoyed increasing success with better survival in recent years. Nevertheless, airway anastomotic complications (AC) are still a potential cause of early morbidity and mortality. In this retrospective cohort study we looked at possible predictors of AC within the first year after LTx. Methods: Between July 1991 and December 2004, 232 consecutive single (n = 102) and bilateral (n = 130) LTx were performed (142 males and 90 females; mean age: 48 years [range 15-66 years]). Indications for LTx were emphysema (n = 113), pulmonary fibrosis (n = 45), cystic fibrosis (n = 35), pulmonary hypertension (n = 10), sarcoidosis (n = 7) and miscellaneous (n = 22). Donor variables (age, gender, PaO 2 / FiO 2 , mechanical ventilation, ischemic time and preservation solution) and recipient variables (age, diagnosis, length, gender, pre-operative steroids, smoking, cytomegalovirus matching, LTx type, anastomotic type, wrapping and bypass) were evaluated in an univariate and multivariate model. Results: Fifty-seven complications occurred in 362 airway anastomoses (15.7%) of which 55 (15.2%) within the first year after transplantation. Six patients died as a result of AC (mortality 2.6%) during the first year after LTx. In a univariate analysis (321 airway anastomoses at risk), anastomotic type (

show abstract

Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 98%

Risk factors for airway complications within the first year after lung transplantation

Wauwer

Raemdonck

Verleden

et al. 2007

European Journal of Cardio-Thoracic Surgery

146

View full text Add to dashboard Cite

show abstract

“…Additionally rejection [3], intense immunosuppressive therapy [4], invasive infections [5], or inadequate organ preservation [2] were factors identified as being associated with compromised airway healing. Furthermore, severe reperfusion edema and early rejection episodes have been shown as independent predictors of bronchial complications [6].…”

Section: Introductionmentioning

confidence: 99%

“…Reflecting these changes, the contemporary rate of anastomotic lesions following LuTx has dropped from 80% before 1983 [15] to 2.6-23.8% [6][7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Airway complications after lung transplantation: risk factors, prevention and outcome☆

Weder

İnci

Korom

et al. 2009

European Journal of Cardio-Thoracic Surgery

113

View full text Add to dashboard Cite

show abstract

“…Improvements in surgical techniques, immunosuppressive regimen, and postoperative care have resulted in markedly improved clinical outcomes, as airway complication rates have decreased, presently ranging from 5% to 30% with an associated mortality rate of 2%-3% [58][59][60][61][62][63].…”

Section: Bronchial Stenosis Following Lung Transplantation (Lt)mentioning

confidence: 99%

Silicone stents, the rigid bronchoscope, and the standard of care in central airway stenosis

Dutau

Maldonado

Laroumagne

et al. 2012

Curr Respir Care Rep

View full text Add to dashboard Cite

Central airway stenoses often represent a therapeutic challenge and require a multidisciplinary approach involving interventional pulmonologists and thoracic surgeons. While surgery is often the preferred definitive modality, advances in bronchoscopic techniques have led to substantial improvements in patient symptoms and longterm quality of life using minimally invasive techniques generally safe when performed by experienced proceduralists. Endobronchial laser therapy, cryotherapy, conventional electrocautery, or argon plasma coagulation and photodynamic therapy have been used successfully. A variety of stents, silicone or self-expandable (covered or non-covered metallic stents), have been used though little significant progress has been achieved since the description of the dedicated airway silicone stents first described by JeanFrancois Dumon in the 1980s. Rigid bronchoscopy remains the method of choice for the treatment of both benign and malignant central airway obstruction, but significant technological advances allow for effective treatments using the flexible bronchoscope. Metallic non-covered stents are generally not recommended, except in selected patients with poor short-term prognosis.

show abstract

Evaluation of factors damaging the bronchial wall in lung transplantation

Cited by 72 publications

References 23 publications

Risk factors for airway complications within the first year after lung transplantation

Risk factors for airway complications within the first year after lung transplantation

Airway complications after lung transplantation: risk factors, prevention and outcome☆

Silicone stents, the rigid bronchoscope, and the standard of care in central airway stenosis

Contact Info

Product

Resources

About