Evaluation of factors related to bone disease in Polish children and adolescents with cystic fibrosis

Update on Bone Health in Pediatric Chronic Disease

“…10 Much of the variance in BMD outcomes may be further explained by the change in forced expiratory volume in one second (FEV 1 ) scores. 14,16 Sands and colleagues 17 also reported on BMD scores as normal in 51% of children, moderately low in 32% of children, and low (as defined by a z score < −2.02) in 17% of children. These results are supported by similar studies with 9% to 27% of children having low BMD; however, other reports have demonstrated normal mineralization when BMD was corrected for body size.…”

“…14–16 To date, there are no long-term studies evaluating fracture risk as related to BMD, and reports on overall BMD outcomes in children and adolescents with CF are conflicting. BMD z scores in adolescents are associated with low BMI and vitamin D levels, worsened disease severity scores, 14,17 and frequency of antibiotic treatments. 10 Much of the variance in BMD outcomes may be further explained by the change in forced expiratory volume in one second (FEV 1 ) scores.…”

“…These results are supported by similar studies with 9% to 27% of children having low BMD; however, other reports have demonstrated normal mineralization when BMD was corrected for body size. 17 BMD as evaluated by DXA has also not improved in the last decade, despite reduction in disease severity and advancements in other modifiable bone risk factors. 15 …”

Evaluation of selected insomnia predictors in adolescents and young adults with cystic fibrosis

“…The study was conducted among 95 cystic fibrosis patients aged [14][15][16][17][18][19][20][21][22][23][24][25] The study involved patients who had agreed to participate voluntarily (the legal guardian's consent was also obtained for patients under 18 years of age). The study excluded patients after lung transplantation, those with diagnosed mental illness, in the terminal state, and with clinical worsening (aggravation of dyspnoea and cough, coughing up sputum, the use of assisted breathing or respirotherapy) in the 4 weeks prior to enrolment, or those who had had traumatic experiences in the last 6 months (e.g.…”

“…FEV1 >70% indicated the early stage of the disease, FEV1 <70% and >40% medium, and FEV1 <40% advanced 23 .…”