Evaluation of factors that can modify platelet-rich plasma properties

Andrade, Miguel Gustavo Setúbal; Brandão, Claudio José de Freitas; Sá, Camila Neves; Bittencourt, Thereza Cristina Borio dos Santos Calmon de; Sadigursky, Moysés

doi:10.1016/j.tripleo.2007.07.032

Cited by 30 publications

(20 citation statements)

References 47 publications

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“…Some investigators have reported significant improvements in tissue healing and bone formation using PRP [1,4,7,8,11,12,[15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] whereas others did not observe improvements [2,5,13,14,[32][33][34][35][36]. Some have given no conclusion regarding effect of PRP application in maxillofacial region than periodontal defects [37].…”

Section: Discussionmentioning

confidence: 99%

“…There are studies that used different materials for activation of platelets before insertion of PRP in surgical defect. Some have used 10 % CaCl 2 alone [2,12,14,15,18,25,29] as we have used. Anitua was the first who began the trend of using only CaCl 2 .…”

Section: Discussionmentioning

confidence: 99%

“…Some had used 10 % CaCl 2 and bovine thrombin [3,10,14,20,21,31,32,34,38] at the same sitting some have used thrombin alone [35,37]. Landesberg et al [2] opposed the use of bovine thrombin, considering the risk of developing antibodies that cross react with factors V, XI and thrombin and induce coagulopathies. Considering these material there was no significant relation between use of different coagulants and outcome.…”

Section: Discussionmentioning

confidence: 99%

“…Centrifugation speed is a relevant variable for platelet count, it was not standardized among the authors and large variation can be noted in the protocols. In some studies there is no information about of centrifugation parameters and the reports of centrifugation parameters in rpm (rotation per minute) mode is another important aspect that makes the comparison of the results difficult [2]. In our study we have used 3,600 rpm for 10 min for separation of platelets that could facilitate bone healing.…”

Section: Discussionmentioning

confidence: 99%

“…Upon their activation, platelet a-granules release over 30 cytokines, including 7 fundamental protein growth factors including platelet-derived growth factor (PDGF) which include the 3 isomers (PDGFaa, PDGFbb and PDGFab), 2 of the numerous transforming growth factors (TGF-b1 and TGF-b2), vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF), and epidermal growth factor (EGF) as well as active substances such as serotonin, catecholamines, von Willebrand factor, proaccelerin, osteonectin, and antimicrobial proteins [2][3][4][5][6][7][8][9]. By concentrating platelets, platelet-rich plasma (PRP) with higher levels of growth factors might be reached, which could stimulate the healing processes.…”

Section: Introductionmentioning

confidence: 99%

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Clinical Evaluation of Use of Platelet Rich Plasma in Bone Healing

Gawai¹,

Sobhana

2014

J. Maxillofac. Oral Surg.

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Background Tooth extraction is performed for a wide variety of reasons as we know. Several techniques aiming at enhancing the regeneration process in the extraction socket have been adopted such as filling the socket with autogenous bone grafts or bone substitutes. We know platelets play a central role in hemostasis and healing processes but relative contradictory effect of platelet in bone regenerating capacity have been published in different in vitro and in vivo studies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Clinical Evaluation of Use of Platelet Rich Plasma in Bone Healing

Gawai¹,

Sobhana

2014

J. Maxillofac. Oral Surg.

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Efficacy of intralesional injections of platelet‐rich plasma in patients with oral lichen planus: A pilot randomized clinical trial

Hijazi

Ahmed

Gaafar

2022

Clinical & Exp Dental Res

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Objective: To evaluate the clinical efficacy of intralesional platelet-rich plasma (PRP) injections compared to intralesional triamcinolone acetonide (TA) injections in the treatment of erosive oral lichen planus (EOLP).Material and Methods: Twenty patients with EOLP were assigned randomly to either PRP or TA group. Patients received weekly intralesional injections for 4 weeks, and then followed up for 3 months on regular visits every 2 weeks. Pain scores using numerical pain score and clinical score were recorded by a blinded assessor each visit for all patients and remission score at the end of the trial was recorded.Results: Both groups showed significant improvement in the clinical parameters (pain and clinical score) "p = .001." Regarding remission of the lesions, 80% of patients in the PRP group showed complete remission compared to 70% in the TA group. However, there is no statistical significance when comparing the two groups in pain score, clinical score, or remission.Conclusions: PRP injections could be considered as an effective alternative single treatment modality for EOLP. The protocol for this study registered in Clinicaltrials.gov registry under the identifier number: NCT03293368.

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Flow Cytometry Analysis of IL-1 Receptors and Toll-Like Receptors on Platelets and Platelet-Derived Extracellular Vesicles

Anselmo,

Boselli

2023

Methods in Molecular Biology

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Evaluation of factors that can modify platelet-rich plasma properties

Cited by 30 publications

References 47 publications

Clinical Evaluation of Use of Platelet Rich Plasma in Bone Healing

Clinical Evaluation of Use of Platelet Rich Plasma in Bone Healing

Efficacy of intralesional injections of platelet‐rich plasma in patients with oral lichen planus: A pilot randomized clinical trial

Flow Cytometry Analysis of IL-1 Receptors and Toll-Like Receptors on Platelets and Platelet-Derived Extracellular Vesicles

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