Evaluation of Fasting Blood Sugar and Lipid Profile in Patients with Type 1 and Type 2 Diabetes and Normoglycemic Individuals in Gorgan, Northeastern

Sarhadi, Nasim Arab; Fakhreddin-nejad, Mohammad-ebrahim; Rajabi, Mohammad-hassan; Mokarrari, Soleiman; Naghipour, Ebrahim; Hooshmand, Karkon; Hashemi, Mohammad

doi:10.29252/jcbr.3.1.6

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…Serum glucose, HbA1c, serum insulin, ALP, cholesterol, triglycerides and LDL-C were significantly higher in patients than in controls whereas serum calcium was significantly lower in patients. Similar results were documented in the literature including Arab countries such as Egyptian and Algerian population [49][50][51]. The levels of HbA1c in the blood reflect the glucose levels to which the erythrocyte has been exposed during its lifespan [52].…”

Section: Table 3 Serum Vitamin D and Its Categories In Controls And Diabetic Patientssupporting

confidence: 85%

Vitamin D and its relation to metabolic profile in type 1 diabetic patients from Gaza Strip

Yassin¹,

Alghora²,

Elhamalawi³

et al. 2020

Integr Food Nutr Metab

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Background: Recent research indicated the involvement of vitamin D in the pathophysiology of type 1 diabetes. In this study, we investigated serum vitamin D status and its relation to metabolic profile in type 1 diabetic patients from Gaza Strip. Methods:This study was a case-control design and included 44 type 1 diabetic patients as well as 44 non-diabetic controls. Patients and controls were matched for age, gender and body mass index (BMI). Data were obtained from questionnaire interview, and biochemical analysis of blood samples.Results: Serum vitamin D was significantly lower in diabetic patients compared to non-diabetic controls (34.1 ± 19.1 versus 43.9 ± 16.9 ng/dl, P=0.012). The number of patients having vitamin D deficient, insufficient and sufficient were 5 (11.4%), 20 (45.5%) and 19 (43.2%) compared to controls of 0 (0.0%), 13 (29.5%) and 31 (70.5%), respectively (χ 2 (corrected) =6.711, P=0.035). Serum glucose, glycated hemoglobin (HbA1c), serum insulin, alkaline phosphatase (ALP), cholesterol, triglycerides and low-density lipoprotein cholesterol (LDL-C) were significantly higher in patients than in controls whereas serum calcium was significantly lower in patients. Serum vitamin D showed significant negative correlations with HbA1c (r=-0.258, P=0.015), insulin (r=-0.257, P=0.016) and LDL-C (r=-0.281, P=0.008) whereas significant positive correlation was found with calcium (r=0.251, P=0.018). Conclusion:The relationship of vitamin D with HbA1c, LDL-C and calcium suggests that vitamin D and/or calcium system may represent a future target for the design of novel therapeutic strategies for patients with type 1 Diabetes.

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Section: Table 3 Serum Vitamin D and Its Categories In Controls And Diabetic Patientssupporting

confidence: 85%

Vitamin D and its relation to metabolic profile in type 1 diabetic patients from Gaza Strip

Yassin¹,

Alghora²,

Elhamalawi³

et al. 2020

Integr Food Nutr Metab

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“…Fasting blood glucose was taken after twelve hours of fasting, followed by blood tests. Fasting blood glucose was measured by glucose oxidase method, lipid profile (triglyceride and total cholesterol) and HDL by immunocolorimetric assay, and LDL by Friedewald equation [20,21]. People with metabolic syndrome were considered as positive and otherwise as negative exposure.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of different types of arsenic methylation and its relationship with metabolic syndrome in an area chronically exposed to arsenic

Kazemifar

Shafikhani

Mozhdehipanah

et al. 2020

Environ Anal Health Toxicol

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Evidence suggests that the relationship between arsenic metabolism and diseases, including metabolic syndrome, is complex. The aim of this study was to evaluate the different types of arsenic methylation and its association with metabolic syndrome in an arsenic endemic area. A cross-sectional study was conducted on 132 subjects from Shahid-Abad Village, Qazvin province, Iran (arsenic endemic area). Demographic characteristics, metabolic syndrome, and urinary arsenic species, including iAs (inorganic arsenic), MMA (monomethylarsonic acid), and DMA (dimethylarsinic acid) were measured for all patients and their relationship was analyzed by appropriate statistical methods. In this study, 34.5% of the participants had metabolic syndrome. The decrease in %MMA, increase in %DMA and increase in secondary methylation index (DMA/MMA) were associated with increased risk of metabolic syndrome (p<0.05). We did not find any association between the incidence of metabolic syndrome with primary methylation index (MMA/iAs) and %iAs (p>0.05). This study showed that the prevalence of metabolic syndrome was significantly higher in people with metabolic syndrome than in the general population. A closer examination revealed that the secondary methylation index is related to the metabolic syndrome and its components. Given the higher prevalence of cardiovascular disease and diabetes in patients with metabolic syndrome, it is necessary to change the pathogenesis of the disease using comprehensive management methods for decreasing patient complications.

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“…Hasil penelitian ini juga menemukan bahwa terdapat korelasi positif lemah antara kadar GDP dengan rasio TG/HDL-K, apabila terdapat peningkatan kadar GDP maka akan disertai peningkatan rasio TG/HDL-K. Sesuai dengan penelitian lain yang membuktikan bahwa pada pasien sindroma metabolik, resistensi insulin berkorelasi signifikan dengan peningkatan rasio TG/HDL-K. GDP juga ditemukan berkorelasi signifikan dengan dengan rasio TG/HDL-K (González-Chávez et al,2011). Kekuatan korelasi antara GDP dengan rasio TG/HDL-K pada penelitian ini tergolong rendah, karena masih banyak faktor yang mempengaruhi kadar TG dan HDL-K dalam darah selain kendali glikemik (Arab Sarhadi et al, 2019). Salah satu faktor penyebab kadar GDP berkorelasi lemah dengan rasio TG/HDL-K adalah responden telah menjalani terapi statin sehingga menyebabkan perubahan kadar lipid dalam darah.…”

Section: Hasilunclassified

KORELASI HbA1c DAN GULA DARAH PUASA TERHADAP RASIO TG/HDL-K PASIEN DIABETES MELLITUS TIPE 2 BERETNIS JAWA

Tursinawati,

Sakinah,

Wahab

et al. 2023

BIGES JUKES

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Background : Most of the causes of death in type 2 Diabetes Mellitus (T2DM) are coronary heart disease (CHD) with dyslipidemia as one of its risk factors. The best marker for early detection of dyslipidemia is the ratio of triglycerides to high-density lipoprotein cholesterol (TG/HDL-C). In T2DM patients, glycemic control in the form of Fasting Blood Sugar (GDP) and HbA1c can be done to avoid the risk of CHD. This study aims to identify the correlation of Hba1c and GDP with the ratio of TG/HDL-K in T2DM patients with Javanese ethnicity.Methods : This research was a cross sectional study involving 107 respondents from several health centers in Semarang City with consecutive sampling method. GDP, HbA1c, and TG/HDL-K ratio were obtained from medical records. Spearman correlation statistical test was used with a significance value of p <0.05. Results: The average HbA1c (7.86 ±1.97%), GDP (160.36± 76.82gr/dL), and the TG/HDL-K ratio (3.50± 2.22) exceeded the normal number. There was a weak significant correlation between GDP and the TG/HDL-K ratio (p=0.020; r=0.224) and there was no correlation between HbA1c and the TG/HDL-K ratio (p=0.549; r=0.059) in T2DM patients with Javanese ethnicity.Conclusion: The GDP of Javanese T2DM patients is weakly correlated with the TG/HDL-K ratio but not with HbA1c. Glycemic control is needed as an early marker of CHD risk in T2DM.

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Evaluation of Fasting Blood Sugar and Lipid Profile in Patients with Type 1 and Type 2 Diabetes and Normoglycemic Individuals in Gorgan, Northeastern

Cited by 4 publications

References 16 publications

Vitamin D and its relation to metabolic profile in type 1 diabetic patients from Gaza Strip

Vitamin D and its relation to metabolic profile in type 1 diabetic patients from Gaza Strip

Evaluation of different types of arsenic methylation and its relationship with metabolic syndrome in an area chronically exposed to arsenic

KORELASI HbA1c DAN GULA DARAH PUASA TERHADAP RASIO TG/HDL-K PASIEN DIABETES MELLITUS TIPE 2 BERETNIS JAWA

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