Evaluation of fine needle aspiration cytology in the diagnosis of cervical lymph node lymphomas

Houcine, Yoldez; Romdhane, Emna; Blel, Ahlem; Ksentini, Meriem; Aloui, Raoudha; Lahiani, Rim; Znaidi, Nadia; Salah, Mamia Ben; Rammeh, Soumaya

doi:10.1016/j.jcms.2018.04.024

Cited by 30 publications

(34 citation statements)

References 17 publications

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“…This finding is in accordance with other studies that have shown that the success of FNAC highly depends on the training and experience of the personnel conducting the procedure [28,29]. An experienced pathologist can assess adequacy repeatedly on-site until adequate material is obtained [26].…”

Section: Discussionsupporting

confidence: 91%

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Analysis of the causes of cervical lymphadenopathy using fine-needle aspiration cytology combining cell block in Chinese patients with and without HIV infection

et al. 2020

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Background: Cervical lymphadenopathy refers to a frequently observed clinical presentation in numerous pathological conditions. A wide spectrum of diseases can cause cervical lymphadenopathy, irrespective of the fact that the patients are infected with HIV or not. The present study focuses on validating whether the causes of cervical lymphadenopathy differ significantly in HIV and non-HIV patients by using fine-needle aspiration cytology (FNAC) combining cell block. Methods: A total of 589 patients with cervical lymphadenopathy were recruited in the FNA clinic. The samples were obtained by an auto-vacuumed syringe that benefited the sampling more materials. The cytological smears were prepared by Hematoxylin and Eosin (HE), Periodic Acid Schiff (PAS), Gomori's methenamine silver (GMS) and acid-fast staining. Cell blocks were made if required, and immunohistochemistry stain was performed on the cell block section.

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Section: Discussionsupporting

confidence: 91%

“…Literature suggests that the frequency of lymphomas ranges between 5 and 41% [25]. Low frequencies of lymphomas were observed in Asian and African studies, probably because of the high frequency of infectious diseases, primarily tuberculosis, in those countries [26].…”

Section: Discussionmentioning

confidence: 98%

Analysis of the causes of cervical lymphadenopathy using fine-needle aspiration cytology combining cell block in Chinese patients with and without HIV infection

et al. 2020

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“…Only 5 studies meeting selection criteria for this guideline statement that compared FNA cytomorphology and a gold standard comparator, including excisional tissue biopsy or other diverse studies (eg, repeat procedure, addition of ancillary testing, tissue biopsy) and clinical follow-up, were identified. The scenarios were typical for FNA sampling: evaluation of head and neck suspected lymphoma, 29 palpable cervical lymph nodes, 30 difficult-toaccess nodes or masses, 31 defined patient populations such as bone marrow transplant patients with a more limited number of differential diagnostic questions, 32 or a specific organ where most neoplasms were other tumors and lymphomas were infrequent incidental findings, as exemplified by the study of thyroid FNAs. 33 In a cervical lymph node study 30 on FNAs from 851 patients in Tunisia, the incidence of lymphoma was 6.9% of total neoplasms.…”

Section: Strong Recommendation-clinical Care Providersmentioning

confidence: 99%

Laboratory Workup of Lymphoma in Adults: Guideline From the American Society for Clinical Pathology and the College of American Pathologists

Kroft

Sever

Bagg

et al. 2020

Archives of Pathology &Amp; Laboratory Medicine

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Context.— The diagnostic workup of lymphoma continues to evolve rapidly as experience and discovery led to the addition of new clinicopathologic entities and techniques to differentiate them. The optimal clinically effective, efficient, and cost-effective approach to diagnosis that is safe for patients can be elusive, in both community-based and academic practice. Studies suggest that there is variation in practice in both settings. Objective.— To develop an evidence-based guideline for the preanalytic phase of testing, focusing on specimen requirements for the diagnostic evaluation of lymphoma. Design.— The American Society for Clinical Pathology, the College of American Pathologists, and the American Society of Hematology convened a panel of experts in the laboratory workup of lymphoma to develop evidence-based recommendations. The panel conducted a systematic review of literature to address key questions. Using the Grading of Recommendations Assessment, Development, and Evaluation approach, recommendations were derived based on the available evidence, strength of that evidence, and key judgements as defined in the Grading of Recommendations Assessment, Development, and Evaluation Evidence to Decision framework. Results.— Thirteen guideline statements were established to optimize specimen selection, ancillary diagnostic testing, and appropriate follow-up for safe and accurate diagnosis of indolent and aggressive lymphoma. Conclusions.— Primary diagnosis and classification of lymphoma can be achieved with a variety of specimens. Application of the recommendations can guide decisions on specimen suitability, diagnostic capabilities, and correct use of ancillary testing. Disease prevalence in patient populations, availability of ancillary testing, and diagnostic goals should be incorporated into algorithms tailored to each practice environment.

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“…The diagnostic accuracy for this technique is high for metastatic disease 1‐13 . The technique is less successful in the specific diagnosis of lymphadenopathy due to primary lymphoproliferative processes 14 . When combined with ultrasound guidance FNAB demonstrates a diagnostic accuracy between 95% and 100% 1,2,4,5,7‐10 .…”

Section: Introductionmentioning

confidence: 99%

Axillary lymph node metastasis: Fine‐needle aspiration biopsy sensitivity as a function of node size, percent replacement of lymph node by tumor and tumor deposit size

Layfield

Zhang

Esebua

et al. 2020

Diagnostic Cytopathology

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BackgroundFine‐needle aspiration (FNA) is commonly used to investigate lymphadenopathy of suspected metastatic origin. While diagnostic accuracy of FNA for lymph node disease is well described, the relationship between node size, percent tumor replacement, and size of metastatic deposit with diagnostic accuracy is less well documented.MethodsAll axillary lymph nodes undergoing ultrasound‐guided FNA for suspected breast metastases were correlated with subsequent surgical excision specimens. FNAs were judged as positive or negative for malignancy and the percent of false negative FNAs was correlated with node size, percent tumor replacement and size of metastatic depositResultsSensitivities were calculated for nodes greater than 15 mm (92%), nodes 11 to 14.9 mm (83%), nodes 7 to 10.9 mm (61%), and for nodes less than 7 mm (60%). Sensitivity increases with increasing node size (P = .001). Percent tumor replacement correlated with sensitivity: 90% or greater replacement (85%) 60% to 89.9% replacement (75%), 40% to 59.9% replacement (75%) and less than 39.9% replacement (64%)(P < .001). Metastases size correlated with sensitivity: metastases greater than 10 mm (94%), 6 to 9.9 mm (70%), 4 to 5.9 mm (54%), and less than 4 mm (72%).ConclusionsPercentage of false negative FNAs associate with investigation of metastatic disease correlates with node size, size of metastatic deposit and percentage of nodes replaced by tumor. Lymph nodes smaller than 7 mm, deposit diameter less than 6 mm and percentage replacement of less than 40% have the highest percentage of false negative results.

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Evaluation of fine needle aspiration cytology in the diagnosis of cervical lymph node lymphomas

Cited by 30 publications

References 17 publications

Analysis of the causes of cervical lymphadenopathy using fine-needle aspiration cytology combining cell block in Chinese patients with and without HIV infection

Analysis of the causes of cervical lymphadenopathy using fine-needle aspiration cytology combining cell block in Chinese patients with and without HIV infection

Laboratory Workup of Lymphoma in Adults: Guideline From the American Society for Clinical Pathology and the College of American Pathologists

Axillary lymph node metastasis: Fine‐needle aspiration biopsy sensitivity as a function of node size, percent replacement of lymph node by tumor and tumor deposit size

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