Evaluation of fine needle aspiration biopsy as a diagnostic tool in pediatric head and neck lesions

Dutta, Shyamoli; Awasthi, Seema; Agarwal, Deepti; Bansal, Rani; Bansal, Prateek

doi:10.2147/plmi.s14040

Cited by 4 publications

(9 citation statements)

References 13 publications

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“…The results of the present study were in concordance with Singh et al [13] who observed 71% cases of reactive LAD, 25.8% of granulomatous LAD, and 3.5% of acute suppurative LAD. Similar results with non-specific reactive LAD as predominant pattern were seen in studies by Handa et al [13] and Aggarwal et al [15]. On cytohistological correlation, there was one false-negative case were a case of Hodgkin's lymphoma was missed and reported as reactive LAD on cytology.…”

Section: Discussionsupporting

confidence: 86%

Clinico-Cytological and Histopathological Correlation of Lymphadenopathy in Pediatric Patients

MAHAJAN

SINGAL

KUNDAL

et al. 2022

Asian J Pharm Clin Res

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Objective: The aim of the present study was to evaluate the cytomorphological and histopathological (wherever possible) patterns of lymph node (LN) lesions along with clinical correlation in the pediatric population. Methods: This was a prospective study conducted on 100 pediatric patients (aged <12 years) who presented with lymphadenopathy (LAP). Fine-needle aspiration cytology (FNAC) was performed on all cases out of which only 22 underwent surgical excision and histopathological examination. Aspirated material was stained with May-Grunwald Giemsa, Papanicolaou, Z-N stain (wherever required) and for histopathology, Hematoxylin and eosin stain was used. Results: Majority number of patients was in the age group of 5–8 years (44%). Cervical LN s were most commonly involved (71%). Out of the total 100 cases, 91% were benign, 3% were malignant and 6% were inadequate. Most common cytologically diagnosed entity was non-specific reactive lymphadenitis (68%). There was one case of reactive lymphadenitis on cytology that proved to be Hodgkin lymphoma on histopathology. Two cases of generalized LAP given as atypical lymphoproliferative lesion on cytopathology proved to be acute lymphoblastic leukemia/lymphoma on further investigation. The cytomorphological findings were found to be concordant with histopathology in 21 cases out of 22 with a diagnostic accuracy rate of 95.45%. Conclusion: FNAC is especially helpful as LN biopsy is a difficult and invasive procedure in children. Although excision biopsy is the gold standard, FNAC is preferred as first-line investigation. Along with cell block analysis and ancillary techniques, it provides an excellent diagnostic accuracy.

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Section: Discussionsupporting

confidence: 86%

Clinico-Cytological and Histopathological Correlation of Lymphadenopathy in Pediatric Patients

MAHAJAN

SINGAL

KUNDAL

et al. 2022

Asian J Pharm Clin Res

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“…Head and neck region is a common site for occurrence of many types of lesions and it poses a challenging diagnostic problem for the clinician. [ 2 ] The mass lesions in children can be of infective, reactive, cystic, developmental aberrations, or neoplastic in origin. [ 8 ] FNAC being a minimally invasive and cost-effective technique, it is being gaining acceptance in pediatric population.…”

Section: Discussionmentioning

confidence: 99%

“…[ 7 ] It is now considered as the first diagnostic step in the evaluation of head and neck masses in pediatric population. [ 2 ] FNAC helps in triaging the mass lesions based on cytomorphological features, so that the patients can be treated or further investigations can be sought. [ 8 ]…”

Section: Discussionmentioning

confidence: 99%

“…[ 1 ] It is now considered as the first-line diagnostic tool. [ 2 ] In addition to this, ancillary techniques such as cell block preparation, cytogenetics, flow cytometry, and immunohistochemistry can be carried out on the samples obtained from the procedure. [ 3 4 ] Although it has been used as a valuable diagnostic technique for evaluating the mass lesions in adult patients, the application of FNAC in pediatric population was not acknowledged until recently.…”

Section: Introductionmentioning

confidence: 99%

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A Study of Cytomorphological Spectrum of Head and Neck Lesions in Pediatric Age Group

Wadone,

Masgal,

Anita

et al. 2023

Journal of Cytology

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Introduction: Fine Needle Aspiration Cytology (FNAC) is a well-established early diagnostic technique for evaluating mass lesions in adult patients. Now, FNAC in children is gaining acceptance and is used as a first-line investigation in diagnosis of pediatric lesions. Aims: To analyze the cytomorphologic spectrum of head and neck lesions in pediatric age group with histopathological correlation wherever possible and to study the utility of FNAC in pediatric head and neck lesions. Materials and Methods: A prospective study was carried out on all FNACs of head and neck lesions in pediatric age group (0-18 years), detected clinically or under radiological guidance for a period of 3 years from August 2018 to July 2021. Results: The study included 238 cases. Most of the cases were seen in the age group of 13-18 years and with male to female ratio of 1.35:1. Most common site of FNAC was lymph nodes (70.2%) and the commonest lesion encountered was reactive lymphadenitis (50.8%). Second most common site was thyroid (15.9%). Soft tissue/bone, salivary gland, miscellaneous/skin lesions were also encountered. Among the 43 neoplastic lesions, benign (31 cases) were more common than the malignant (12 cases). The malignant cases included non-Hodgkins lymphoma, Hodgkins lymphoma, metastasis to lymph node, low-grade sarcoma, papillary thyroid carcinoma, and Langerhans cell histiocytosis of bone. Histopathological correlation was done in 32 cases (13.4%). Statistical analysis showed a sensitivity of 85.29% and specificity of 97.74%. Overall diagnostic accuracy was 96.3%. Conclusion: This study highlighted various cytomorphological patterns in head and neck lesions with high diagnostic accuracy in children. FNAC helps in proper planning of treatment modalities in head and neck masses in pediatric age group.

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“…Its introduction into the routine pediatric diagnostic algorithm has been fairly recent. [ 1 ] Although there are existing reports in the literature on utility of FNAC in the pediatric patients, the majority of such descriptions have included a specific body site or a particular disease entity. [ 2 - 4 ] Only occasional studies on pediatric FNAC have included both benign and malignant lesions encompassing various body sites.…”

Section: Introductionmentioning

confidence: 99%

Pediatric fine-needle aspiration cytology: An audit of 266 cases of pediatric tumors with cytologic-histologic correlation

et al. 2020

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Objectives: Fine-needle aspiration cytology (FNAC), a well-accepted minimally invasive diagnostic technique utilized in adults, is gradually gaining ground for pediatric patients as well. However, there are very few comprehensive reports in the literature on utility of FNA in pre-operative diagnosis of pediatric tumors. Material and Methods: An observational study was conducted at a cancer research center and a pediatric tertiary care hospital over a 5-year period. A cytologic-histologic correlation was performed for FNACs performed in pediatric patients for a clinical diagnosis of neoplastic lesions at both the centers. Relevant clinical details and histopathology, wherever available, were retrieved. Sensitivity, specificity, and accuracy of FNAC in diagnosis of malignant lesion were calculated from the cases with available histologic correlation. Results: Of the 266 cases included, there was a slight male predominance with lymphadenopathy being the most common presentation and non-Hodgkin’s lymphoma as the most frequent diagnosis in cases clinically suspected to have a neoplasm. Histologic correlation was available in 112 cases with 100% concordance in liver and kidney tumors. Few rare cytologic diagnoses such as papillary renal cell carcinoma, mesenchymal hamartoma of the liver, and thymolipoma could be accurately rendered on FNAC smears in conjunction with the clinic-radiologic features. The sensitivity, specificity, and accuracy of FNA in diagnosing malignant pediatric tumors were found to be 100%, 92.6%, and 97.7%, respectively. Conclusion: The present study underscores the high sensitivity and accuracy of FNAC in diagnosis of pediatric tumors, both in superficial and deep-seated locations. Awareness of the cytomorphologic features and clinic-radiologic correlation may assist the cytopathologists in rendering a precise diagnosis of rare pediatric tumors as well.

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Evaluation of fine needle aspiration biopsy as a diagnostic tool in pediatric head and neck lesions

Cited by 4 publications

References 13 publications

Clinico-Cytological and Histopathological Correlation of Lymphadenopathy in Pediatric Patients

Clinico-Cytological and Histopathological Correlation of Lymphadenopathy in Pediatric Patients

A Study of Cytomorphological Spectrum of Head and Neck Lesions in Pediatric Age Group

Pediatric fine-needle aspiration cytology: An audit of 266 cases of pediatric tumors with cytologic-histologic correlation

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