Evaluation of Fixed Oil, Seed Extracts, of &amp;lt;i&amp;gt;Carum carvi&amp;lt;/i&amp;gt; L

Abdalaziz, Mohamed N.

doi:10.11648/j.ijctc.20170501.11

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…Previous studies highlighted several pharmacological effects of carvone and its derivatives as antimicrobial compound [15] , antifungal [16] , and antitumoral [ 15 , 17 , 18 ]. Different conventional methods, such as hydrodistillation [19] , soxhlet [20] and supercritical fluid extraction [21] , are used to extract EOs from C. carvi seeds, where reports usually highlighted large amounts of carvone (50-60%) and limonene (30-40%) in the volatile fraction [ 21 , 22 ]. Post-synthetic modification of ( s )-carvone present in raw plant materials, by mean of its ketone function, may exhibit interesting biologically active compounds associated with a chiral interaction that plays a crucial role in the elaboration of synthetic or hemi-synthetic anticancer drugs [ 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Hemi-synthesis of novel (S)-carvone hydrazone from Carum carvi L. essential oils: Structural and crystal characterization, targeted bioassays and molecular docking on human protein kinase (CK2) and Epidermal Growth factor Kinase (EGFK)

Tedjini

Ziani

Casimiro

et al. 2021

Journal of Molecular Structure

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Polyfunctional N,O,O,N-type ligands such as the oxalyl dihydrazide (ODH) may induce formation of mono-, di-, and polynuclear complexes with natural monoterpene ketones, involving ligand bridging and Oxobridging. In this context, a novel chiral dihydrazone is designed through hemi-synthesis process by reacting oxalyldihydrazide (ODH) with ( s )-carvone, the major compound of caraway's seeds essential oil. The C = N imine bi-condensation is performed without prior isolation of the natural ( s )-carvone and the resulting ( s )-carvone dihydrazone (s-CHD) is structurally characterized by Single-crystal X-ray diffraction, 2D-NMR spectroscopy and chiral LCMS analysis to confirm the formation of a single pure enantiomer. In -vitro cell-based assays were conducted on normal fibroblast (L929) using a presBlue (PB) fluorescence quantification method of cell-viability and by sulforhodamine B calorimetric cytotoxicity assays to determine the anti-proliferative effect on four human tumoral lines (NCI-H460, Hela, HepG2 and MCF-7) and normal PLP2. Anti-inflammatory assays were determined through NO production by Maurine LPS-stimulated macrophages (RAW 264.7). The ( s )-CHD has no effect on normal cells viability ( > 88%) and PLP2 (GI50 = 326 ug/mL), while a moderate ( ∼55%) to significant ( ∼63%) antigrowth potential was recorded against HepG2, Hela and MCF-7 tumor cell lines, where RAW 264.7 was feebly sensitive. A molecular docking was performed using Autodock vina software on the protein kinase CK2 and Epidermal Growth factor Kinase proteins EGFK and the dock scores allowed to identify significant binding affinities (lower G and Ki values) and potential hydrophilic/hydrophobic interactions with ( s )-CHD comparing to the clinical ellipticine as potential ligands. Molecular docking suggests that ( s )-CHD possesses high affinity towards the kinase domain receptors CK2 and EGFR, being able to bind to the ATP region.

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Section: Introductionmentioning

confidence: 99%

Hemi-synthesis of novel (S)-carvone hydrazone from Carum carvi L. essential oils: Structural and crystal characterization, targeted bioassays and molecular docking on human protein kinase (CK2) and Epidermal Growth factor Kinase (EGFK)

Tedjini

Ziani

Casimiro

et al. 2021

Journal of Molecular Structure

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Caraway as Important Medicinal Plants in Management of Diseases

Mahboubi¹

2018

Nat. Prod. Bioprospect.

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Carum carvi or caraway is traditionally used for treatment of indigestion, pneumonia, and as appetizer, galactagogue, and carminative. Essential oil, fixed oil and many other valuable extractive compounds with industrial applications are prepared from caraway. This review article has new deep research on caraway as medicinal plant. For preparing the manuscript, the information was extracted from accessible international databases (Google scholar, PubMed, Science direct, Springer, and Wiley), electronic resources and traditional books by key word of caraway or Carum carvi. The results of traditional studies exhibited that the galactagogue and carminative effects of caraway fruits are superior to other effects. Although, the traditional scholars used it as appetizer, while caraway was the main ingredient of anti-obesity drugs in traditional medicine, which has been confirmed in two modern clinical trials of human studies. Caraway oil in combination with peppermint oil or menthol is used for treatment of functional dyspepsia in clinical studies. Caraway oil topically on abdomen relieves the IBS symptoms in patient. Although, the use of caraway oil is not recommended in adults under 18 years due to insufficient data, but it can topically use as anti-colic and carminative agent in children or infants. The anti-aflatoxigenic, antioxidant and antimicrobial effects of caraway oil along with its reputation as spice help the industries to use it as natural preservatives and antioxidant agents.

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A Review of Current Research on Traditional Medicines for the Treatment of Gastrointestinal and Biliary Disorders

Jain

Vishwakarma

Patel

2024

CTM

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Gastrointestinal (GI) and biliary disorders are the most commonly known health issues for people in the present time as a consequence of modern lifestyle, eating habits, stress, and many other conditions. The usage of traditional substances has been phased out over time, resulting in an increase in the occurrence of numerous diseases and a decrease in immunity. Therefore, in the current scenario, traditional medicine is increasingly being used to treat and manage diseases worldwide. Traditional medical systems of India, China, and Africa are the most frequently used today. Indian medicinal system includes the Ayurveda, Siddha, and Unani systems of medicine. Ayurveda is the most antique system of medicine, which relies on the usage of plant-based formulations. Herbal medicines are used nowadays by up to half of the world's population. Phytomedicines isolated from plants contain a wide variety of bioactive components that can have both negative and positive effects. Many herbal plants, such as Acacia, Aloe, Carum, Rose, Funnel, etc., are proven to be effective as phytomedicines that are effective for the cure of gastrointestinal and biliary problems. The available pharmacological therapeutic drugs often have efficacy but are associated with many adverse effects. To minimize the adverse effects, the use of phytomedicines can be the best possible alternative. In this study, a review of some of the most frequently used traditional herbal medicine isolates with their proven pharmacological activity and novel drug delivery systems for the proper delivery of isolates is presented. Moreover, currently available herbal-marketed formulations are also highlighted.

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Evaluation of Fixed Oil, Seed Extracts, of <i>Carum carvi</i> L

Cited by 3 publications

References 9 publications

Hemi-synthesis of novel (S)-carvone hydrazone from Carum carvi L. essential oils: Structural and crystal characterization, targeted bioassays and molecular docking on human protein kinase (CK2) and Epidermal Growth factor Kinase (EGFK)

Hemi-synthesis of novel (S)-carvone hydrazone from Carum carvi L. essential oils: Structural and crystal characterization, targeted bioassays and molecular docking on human protein kinase (CK2) and Epidermal Growth factor Kinase (EGFK)

Caraway as Important Medicinal Plants in Management of Diseases

A Review of Current Research on Traditional Medicines for the Treatment of Gastrointestinal and Biliary Disorders

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