2017
DOI: 10.1016/j.rvsc.2017.04.010
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Evaluation of flunixin meglumine pour-on administration on prostaglandin E2 concentration in inflammatory exudate after induction of inflammation in cattle

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Cited by 15 publications
(8 citation statements)
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“…In addition, experiment two looked at several biologic parameters and physical parameters throughout the study and the following were used for power analysis: plasma cortisol levels, plasma haptoglobin levels, plasma prostaglandin levels, heart rate, dry matter intake, infrared thermography, and a visual analog of pain. The preliminary information for power analysis was obtained from previous literatures on similar research ( Mellor and Molony, 1991 ; Proudfoot et al, 2009 ; Thiry et al, 2017 ; Kleinhenz et al, 2018b ). Power analysis was conducted using PROC GLMPOWER in SAS9.4 TS1M3 for Windows 64× (SAS Institute, Cary, NC).…”
Section: Methodsmentioning
confidence: 99%
“…In addition, experiment two looked at several biologic parameters and physical parameters throughout the study and the following were used for power analysis: plasma cortisol levels, plasma haptoglobin levels, plasma prostaglandin levels, heart rate, dry matter intake, infrared thermography, and a visual analog of pain. The preliminary information for power analysis was obtained from previous literatures on similar research ( Mellor and Molony, 1991 ; Proudfoot et al, 2009 ; Thiry et al, 2017 ; Kleinhenz et al, 2018b ). Power analysis was conducted using PROC GLMPOWER in SAS9.4 TS1M3 for Windows 64× (SAS Institute, Cary, NC).…”
Section: Methodsmentioning
confidence: 99%
“…However, in goats, transdermal flunixin improved fluidity of movement and decreased head pressing following castration indicating a mitigation of pain behavior (Graves et al, 2020). Transdermal flunixin has been shown to have a significant anti-inflammatory effect in cattle and significantly reduced prostaglandin E2 concentrations in a model of acute inflammation (Thiry et al, 2017). Evidence has been reported regarding efficacy of flunixin injectable formulation based on its ability to inhibit prostaglandin synthesis when administered through routes other than the intravenous route in goats (Königsson et al, 2003).…”
Section: Discussionmentioning
confidence: 99%
“…Consistent with previous results, our data also showed that EP attenuates the expression of HMGB1 in piglets infected with G. parasuis . It has been documented that FM exerts significant anti-inflammatory effects in piglets and cattle [ 29 , 30 ]. Flunixin meglumine also reduces the release of the cytokines IL1β, IL10, and TNF-α [ 31 ], so it is considered a good option for controlling inflammation-related diseases, such as G. parasuis infection.…”
Section: Discussionmentioning
confidence: 99%