Evaluation of Fluorescent Cu2+ Probes: Instant Sensing, Cell Permeable Recognition and Quantitative Detection

He, Hao; Cheng, Zhao; Zheng, Lei; Zhang, Xuejiao

doi:10.3390/molecules26020512

Cited by 7 publications

(4 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rhodamine-based probes 4.7 [10] Curcumin nanoparticles probe 1.4 [23] BINOL-based fluorescent sensor 1.5 [39] Coumarin thiazolyl-functionalized Schiff base 1.5 [40] Rhodamine 6G derivatives as probe 37.6 [41] 4-Phenylsemicarbazone 1,2-naphthoquinone-4-sulfonic acid probe 12 [42] Schiff base derivative 180 [43] Fluorescein-based probe 6.3 [44] Red beet pigment method as indicator 54 [45] Cellulose Schiff base 105 [46] Our proposed method 0.94 Our method T A B L E 2 Cu 2+ ion determination from water samples using the standard addition method (n = 3).…”

Section: Fluorescence Quenching Mechanismmentioning

confidence: 99%

SDS‐capped 1‐pyrenecarboxaldehyde nanoprobe for selective detection of Cu²⁺ ion from water samples: Spectroscopic approach

et al. 2023

View full text Add to dashboard Cite

The SDS capped 1‐pyrenecarboxaldehyde nanoparticles (PyalNPs) prepared by reprecipitation method in aqueous medium exhibited red shifted aggregation induced enhanced emission (AIEE). The dynamic light scattering (DLS) examination showed narrower particle size distribution with average particle size 41 nm whereas ‐34.5 mV zeta potential value indicate the negative surface charge and good stability of nanoparticles in aqueous medium. The aggregation induced enhanced emission (AIEE) seen at λmax = 473 nm in fluorescence spectrum of PyalNPs suspension. In presence of Cu2+ ion fluorescence of PyalNPs quenches very significantly even in presence of other metal ions like Ba2+, Ca2+, Cd2+, Co2+, Al3+, Fe2+, Hg2+, Ni2+, Mg2+. The changes in fluorescence life time of PyalNPs in presence of Cu2+ ion suggest the type of quenching is dynamic. The fluorescence quenching data of nanoparticles suspension fits well into typical Stern‐Volmer relation in the range of concentration 1.0‐25 μg/mL of Cu2+ ion. The estimated value of correlation coefficient R2 = 0.9877 close to 1 shows linear relationship between quenching data and Cu2+ ion concentration. The limit of detection (LOD) found to be 0.94 ng/mL is far below than the tolerable intake limit value 1.3 μg/mL accepted by world health organization for Cu2+ ion in drinking water. The fluorescence quenching approach of sodium dodecyl sulfate (SDS) capped Pyal nanosuspension for copper ion quantification is of high specificity and co‐existing ions found interfering very negligibly. The developed method was successfully applied for the estimation of copper ion in river water sample.

show abstract

Section: Fluorescence Quenching Mechanismmentioning

confidence: 99%

SDS‐capped 1‐pyrenecarboxaldehyde nanoprobe for selective detection of Cu²⁺ ion from water samples: Spectroscopic approach

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Currently, Cu 2+ is detected by atomic absorption spectrometry [ 12 ], inductively coupled plasma mass spectrometry [ 13 ], electrochemical methods [ 14 ], etc. In these detection methods, it is indubitably necessary to involve advanced pretreatment processes and several large-scale instruments, which limit rapid detection in the wild and nondestructive functions of organisms [ 15 , 16 , 17 , 18 ]. Fluorescent probes have been widely used in the identification and measurement of Cu 2+ due to their advantages of sensitivity, good biocompatibility, simple operation, and fast and specific recognition [ 19 , 20 , 21 , 22 , 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Development of a Fluorescein-Based Probe with an “Off–On” Mechanism for Selective Detection of Copper (II) Ions and Its Application in Imaging of Living Cells

et al. 2023

View full text Add to dashboard Cite

Copper is a common metallic element that plays an extremely essential role in the physiological activities of living organisms. The slightest change in copper levels in the human body can trigger various diseases. Therefore, it is important to accurately and efficiently monitor copper ion levels in the human body. Recent studies have shown that fluorescent probes have obvious advantages in bioimaging and Cu2+ detection. Therefore, a novel Cu2+ probe (N2) was designed and synthesized from fluorescein, hydrazine hydrate and 5-p-nitrophenylfurfural that is sensitive to and can detect Cu2+ within 100 s. The response mechanism of the N2 probe to Cu2+ was studied by several methods such as Job’s plots and MS analysis, which showed that the Cu2+ and the N2 probe were coordinated in a complexation ratio of 1:1. In addition, compared with other cations investigated in this study, the N2 probe showed excellent selectivity and sensitivity to Cu2+, exhibiting distinct fluorescence absorption at 525 nm. Furthermore, in the equivalent range of 0.1–1.5, there is a good linear relationship between Cu2+ concentration and fluorescence intensity, and the detection limit is 0.10 μM. It is worth mentioning that the reversible reaction between the N2 probe and Cu2+, as well as the good biocompatibility shown by the probe in bioimaging, make it a promising candidate for Cu2+ biosensor applications.

show abstract

“…Rhodamine and rhodamine derivatives have been applied widely as fluorescent probes owing to their remarkable optical characteristics including a high fluorescence quantum yield (Φ), a large molar extinction coefficient (ε), and longer excitation and emission wavelengths. 31 So far, many fluorescent probes utilizing rhodamine derivatives had been utilized to sense different cations including Cu 2+ , 32 Pb 2+ , 33 Cr 3+ , 34 Fe 3+ , 35 Al 3+ , 36 Zn 2+ , 37 and so forth. The sensing mechanism of these probes for cations is based on the transformation from a spirocyclic form into an open cyclic structure.…”

Section: Introductionmentioning

confidence: 99%

Rhodamine-Based Fluorescent Probe for Highly Selective Determination of Hg²⁺

Zhu

et al. 2022

ACS Omega

View full text Add to dashboard Cite

The determination of mercuric ions (Hg 2+ ) in environmental and biological samples has attracted the attention of researchers lately. In the present work, a novel turn-on Hg 2+ fluorescent probe utilizing a rhodamine derivative had been constructed and prepared. The probe could highly sensitively and selectively sense Hg 2+ . In the presence of excessive Hg 2+ , the probe displayed about 52-fold fluorescence enhancement in 50% H 2 O/CH 3 CH 2 OH (pH, 7.24). In the meantime, the colorless solution of the probe turned pink upon adding Hg 2+ . Upon adding mercuric ions, the probe interacted with Hg 2+ and formed a 1:1 coordination complex, which had been the basis for recognizing Hg 2+ . The probe displayed reversible dual colorimetric and fluorescence sensing of Hg 2+ because rhodamine’s spirolactam ring opened upon adding Hg 2+ . The analytical performances of the probe for sensing Hg 2+ were also studied. When the Hg 2+ concentration was altered in the range of 8.0 × 10 –8 to 1.0 × 10 –5 mol L –1 , the fluorescence intensity showed an excellent linear correlation with Hg 2+ concentration. A detection limit of 3.0 × 10 –8 mol L –1 had been achieved. Moreover, Hg 2+ in the water environment and A549 cells could be successfully sensed by the proposed probe.

show abstract

Evaluation of Fluorescent Cu2+ Probes: Instant Sensing, Cell Permeable Recognition and Quantitative Detection

Cited by 7 publications

References 35 publications

SDS‐capped 1‐pyrenecarboxaldehyde nanoprobe for selective detection of Cu²⁺ ion from water samples: Spectroscopic approach

SDS‐capped 1‐pyrenecarboxaldehyde nanoprobe for selective detection of Cu²⁺ ion from water samples: Spectroscopic approach

Development of a Fluorescein-Based Probe with an “Off–On” Mechanism for Selective Detection of Copper (II) Ions and Its Application in Imaging of Living Cells

Rhodamine-Based Fluorescent Probe for Highly Selective Determination of Hg²⁺

Contact Info

Product

Resources

About

Evaluation of Fluorescent Cu2+ Probes: Instant Sensing, Cell Permeable Recognition and Quantitative Detection

Cited by 7 publications

References 35 publications

SDS‐capped 1‐pyrenecarboxaldehyde nanoprobe for selective detection of Cu2+ ion from water samples: Spectroscopic approach

SDS‐capped 1‐pyrenecarboxaldehyde nanoprobe for selective detection of Cu2+ ion from water samples: Spectroscopic approach

Development of a Fluorescein-Based Probe with an “Off–On” Mechanism for Selective Detection of Copper (II) Ions and Its Application in Imaging of Living Cells

Rhodamine-Based Fluorescent Probe for Highly Selective Determination of Hg2+

Contact Info

Product

Resources

About

SDS‐capped 1‐pyrenecarboxaldehyde nanoprobe for selective detection of Cu²⁺ ion from water samples: Spectroscopic approach

SDS‐capped 1‐pyrenecarboxaldehyde nanoprobe for selective detection of Cu²⁺ ion from water samples: Spectroscopic approach

Rhodamine-Based Fluorescent Probe for Highly Selective Determination of Hg²⁺