Evaluation of folate conjugated pegylated thermosensitive magnetic nanocomposites for tumor imaging and therapy

Rastogi, Rachna; Gulati, Nany; Kotnala, R.K.; Sharma, Uma; Jayasundar, Rama; Koul, Veena

doi:10.1016/j.colsurfb.2010.08.037

Cited by 65 publications

(33 citation statements)

References 19 publications

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“…Folate, furthermore, was conjugated onto PAA-IONPs, yielding targeting functionality aimed at targeted killing of folate receptor-overexpressing cancer cells, demonstrated by optical/MR imaging. 18 In a later study by Rastogi et al, 19 three polymers with varied functionalities surrounding the superparamagnetic IONPs to generate a thermosensitive nanocarrier were presented. While N-isopropylacrylamide (NIPAAM) acted as a temperature-sensitive polymer for hyperthermia capability, acrylic acid was utilized to enhance conjugation to an iron surface as well as tune critical temperature by its hydrophilic nature.…”

Section: Magnetic Nanomaterialsmentioning

confidence: 99%

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Nanotheranostics – a review of recent publications

Wang¹,

Chuang²,

Ho³

2012

IJN

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Theranostics is referred to as a treatment strategy that combines therapeutics with diagnostics, aiming to monitor the response to treatment and increase drug efficacy and safety, which would be a key part of personalized medicine and require considerable advances in predictive medicine. Theranostics associates with both a diagnosis that tests patients for possible reactions to taking new medication and targeted drug delivery based on the test results. Emerging nanotechnology provides a great deal of opportunity to design and develop such combination agents, permitting the delivery of therapeutics and concurrently allowing the detection modality to be used not only before or after but also throughout the entire treatment regimen. The introduction of nanotheranostics into routine health care has still a long way to go, since evaluations on cytotoxicity, genotoxicity, and immunotoxicity of prospective nanotheranostics, demonstration of cost-effectiveness, and availability of appropriate accessible testing systems are still required. An extensive review, from a chemistry point of view, of the recent development of nanotheranostics and its in vitro and in vivo applications are herein presented.

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Section: Magnetic Nanomaterialsmentioning

confidence: 99%

“…In a recent study carried out by Hu et al 14 the photothermal effect of AuNR was efficiently improved by a surrounding silver shell (AuNR-in-shell). The Chemotherapy X-ray imaging MR imaging [19][20][21][22][23][24][25] [27]…”

Section: Gold-based Nanomaterialsmentioning

confidence: 99%

Nanotheranostics – a review of recent publications

Wang¹,

Chuang²,

Ho³

2012

IJN

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“…Folate receptor-α is a glycosylphosphatidylinositol-anchored protein and one of the most prevalent receptors investigated for targeting, despite its ubiquitous presence in the body, on account of its significant overproduction and presence on the surface of a wide spectrum of tumors, particularly those of epithelial origin. 24,26,55,56 Folic acid, the ligand responsible for binding to this receptor, is a popular ligand, as it is small and nonimmunogenic, has a high affinity for the folic acid receptor, and is hardly problematic to procure. 29 Table 1 briefly outlines different nanosystem configurations that have been functionalized for targeting the folate receptor.…”

Section: Folate Receptor-αmentioning

confidence: 99%

“…54,119,125 At room temperature, these nanoparticles undergo strong magnetization in the presence of a magnetic field, which is reversed at the removal of the magnetic field. 56 This allows for external manipulation to achieve a specific result, whether imaging of a specific region or body system or stimuli-responsive drug release. In addition, the high surface-area-to-volume ratio makes them ideal for the conjugation of targeting moieties to tailor the application.…”

Section: Magnetic Nanoparticlesmentioning

confidence: 99%

“…Moreover, the chosen polymers often had properties that were advantageous to the function of the magnetic nanoparticles, such as increasing circulation lifespan in vivo (PEG) and temperature-and pH-responsiveness (N-isopropylacrylamide, Chitosan). 56 Modification of magnetic nanoparticles attempted by Rastogi et al included the use of thermosensitive polymers for hyperthermia-induced drug release, as well as folic acid conjugation for active tumor targeting. 56 Magnetic resonance imaging conducted with the formulation attested to its applicability to in vivo use, whereas drug release was determined to be site-specific as a result of folic acid targeting, the nanosize capitalizing on the EPR effect, and an externally applied thermal stimulus.…”

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confidence: 99%

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Overview of the role of nanotechnological innovations in the detection and treatment of solid tumors

Frank¹,

Tyagi²,

Tomar³

et al. 2014

IJN

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Nanotechnology, although still in its infantile stages, has the potential to revolutionize the diagnosis, treatment, and monitoring of disease progression and success of therapy for numerous diseases and conditions, not least of which is cancer. As it is a leading cause of mortality worldwide, early cancer detection, as well as safe and efficacious therapeutic intervention, will be indispensable in improving the prognosis related to cancers and overall survival rate, as well as health-related quality of life of patients diagnosed with cancer. The development of a relatively new field of nanomedicine, which combines various domains and technologies including nanotechnology, medicine, biology, pharmacology, mathematics, physics, and chemistry, has yielded different approaches to addressing these challenges. Of particular relevance in cancer, nanosystems have shown appreciable success in the realm of diagnosis and treatment. Characteristics attributable to these systems on account of the nanoscale size range allow for individualization of therapy, passive targeting, the attachment of targeting moieties for more specific targeting, minimally invasive procedures, and real-time imaging and monitoring of in vivo processes. Furthermore, incorporation into nanosystems may have the potential to reintroduce into clinical practice drugs that are no longer used because of various shortfalls, as well as aid in the registration of new, potent drugs with suboptimal pharmacokinetic profiles. Research into the development of nanosystems for cancer diagnosis and therapy is thus a rapidly emerging and viable field of study.

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Iron Oxide Nanotubes for Magnetically Guided Delivery and pH‐Activated Release of Insoluble Anticancer Drugs

Yue

Wei

You

et al. 2011

Adv Funct Materials

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Low solubility in water is an intrinsic property of many drugs, which hinders the clinical use of those active ingredients. To break this bottleneck, we attempt to develop an iron oxide nanoparticle‐based multifunctional system. Firstly, we perform PEG coating and compare the feasibility of spherical and rod‐like iron oxide nanoparticles in a view of carcinoma cellular uptake; rod‐like nanoparticles attracted our interest since they could be quickly and massively internalized. For paclitaxel (PTX) loading, we next transform the nanorods into a tube structure by a hydrothermal method. The results show that drug crystals can be successfully loaded in the inner voids of these nanotubes (PMNTs) by controlling the crystallization process of PTX. The acquired nanocomplexes not only escape phagocytosis of macrophage cells by a PEG stealth effect, but also exhibit an increased cellular uptake with magnetic field exposure. In addition, this iron oxide‐based drug carrier possesses a low pH‐activated release profile, which would accelerate drug release in the carcinoma cells and minimize non‐specific drug release. Owing to these advantages, PMNTs promote the anticancer efficacy of PTX and clearly exhibit promising potential for using as high‐efficiency insoluble drug delivery system in clinical applications.

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Evaluation of folate conjugated pegylated thermosensitive magnetic nanocomposites for tumor imaging and therapy

Cited by 65 publications

References 19 publications

Nanotheranostics – a review of recent publications

Nanotheranostics – a review of recent publications

Overview of the role of nanotechnological innovations in the detection and treatment of solid tumors

Iron Oxide Nanotubes for Magnetically Guided Delivery and pH‐Activated Release of Insoluble Anticancer Drugs

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Evaluation of folate conjugated pegylated thermosensitive magnetic nanocomposites for tumor imaging and therapy

Cited by 65 publications

References 19 publications

Nanotheranostics &ndash; a review of recent publications

Nanotheranostics &ndash; a review of recent publications

Overview of the role of nanotechnological innovations in the detection and treatment of solid tumors

Iron Oxide Nanotubes for Magnetically Guided Delivery and pH‐Activated Release of Insoluble Anticancer Drugs

Contact Info

Product

Resources

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Nanotheranostics – a review of recent publications

Nanotheranostics – a review of recent publications