Evaluation of Forkhead BOX M1 (FOXM1) gene expression in colorectal cancer

Rather, Tahseen Bilal; Parveiz, Ishrat; Bhat, Gulzar Ahmad; Rashid, Gowhar; Wani, Rauf Ahmad; Khan, Ishrat Younas; Mudassar, Syed

doi:10.1007/s10238-022-00929-7

Cited by 3 publications

(1 citation statement)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rather et al. investigated the expression of FOXM1 in 98 CRC samples and normal tissues, and found that FOXM1 was elevated in CRC and linked to reduced disease-free survival ( 172 ). Overexpression of FOXM1 in tumor tissues is also significantly related to metastasis in CRC through the induction of EMT ( 173 ).…”

Section: Tumor-associated Splicing Variants In Crc: From Roles To Pot...mentioning

confidence: 99%

Targeted splicing therapy: new strategies for colorectal cancer

Zheng,

Zhong,

et al. 2023

Front. Oncol.

View full text Add to dashboard Cite

RNA splicing is the process of forming mature mRNA, which is an essential phase necessary for gene expression and controls many aspects of cell proliferation, survival, and differentiation. Abnormal gene-splicing events are closely related to the development of tumors, and the generation of oncogenic isoform in splicing can promote tumor progression. As a main process of tumor-specific splicing variants, alternative splicing (AS) can promote tumor progression by increasing the production of oncogenic splicing isoforms and/or reducing the production of normal splicing isoforms. This is the focus of current research on the regulation of aberrant tumor splicing. So far, AS has been found to be associated with various aspects of tumor biology, including cell proliferation and invasion, resistance to apoptosis, and sensitivity to different chemotherapeutic drugs. This article will review the abnormal splicing events in colorectal cancer (CRC), especially the tumor-associated splicing variants arising from AS, aiming to offer an insight into CRC-targeted splicing therapy.

show abstract

Section: Tumor-associated Splicing Variants In Crc: From Roles To Pot...mentioning

confidence: 99%

Targeted splicing therapy: new strategies for colorectal cancer

Zheng,

Zhong,

et al. 2023

Front. Oncol.

View full text Add to dashboard Cite

show abstract

SP1-Driven FOXM1 Upregulation Induces Dopaminergic Neuron Injury in Parkinson’s Disease

Dong,

Gao

2024

Mol Neurobiol

View full text Add to dashboard Cite

Global transcriptomic network analysis of the crosstalk between microbiota and cancer-related cells in the oral-gut-lung axis

Otálora-Otálora,

Payán-Gómez,

López-Rivera

et al. 2024

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

BackgroundThe diagnosis and treatment of lung, colon, and gastric cancer through the histologic characteristics and genomic biomarkers have not had a strong impact on the mortality rates of the top three global causes of death by cancer.MethodsTwenty-five transcriptomic analyses (10 lung cancer, 10 gastric cancer, and 5 colon cancer datasets) followed our own bioinformatic pipeline based on the utilization of specialized libraries from the R language and DAVID´s gene enrichment analyses to identify a regulatory metafirm network of transcription factors and target genes common in every type of cancer, with experimental evidence that supports its relationship with the unlocking of cell phenotypic plasticity for the acquisition of the hallmarks of cancer during the tumoral process. The network’s regulatory functional and signaling pathways might depend on the constant crosstalk with the microbiome network established in the oral-gut-lung axis.ResultsThe global transcriptomic network analysis highlighted the impact of transcription factors (SOX4, TCF3, TEAD4, ETV4, and FOXM1) that might be related to stem cell programming and cancer progression through the regulation of the expression of genes, such as cancer-cell membrane receptors, that interact with several microorganisms, including human T-cell leukemia virus 1 (HTLV-1), the human papilloma virus (HPV), the Epstein–Barr virus (EBV), and SARS−CoV−2. These interactions can trigger the MAPK, non-canonical WNT, and IFN signaling pathways, which regulate key transcription factor overexpression during the establishment and progression of lung, colon, and gastric cancer, respectively, along with the formation of the microbiome network.ConclusionThe global transcriptomic network analysis highlights the important interaction between key transcription factors in lung, colon, and gastric cancer, which regulates the expression of cancer-cell membrane receptors for the interaction with the microbiome network during the tumorigenic process.

show abstract

Evaluation of Forkhead BOX M1 (FOXM1) gene expression in colorectal cancer

Cited by 3 publications

References 46 publications

Targeted splicing therapy: new strategies for colorectal cancer

Targeted splicing therapy: new strategies for colorectal cancer

SP1-Driven FOXM1 Upregulation Induces Dopaminergic Neuron Injury in Parkinson’s Disease

Global transcriptomic network analysis of the crosstalk between microbiota and cancer-related cells in the oral-gut-lung axis

Contact Info

Product

Resources

About