Evaluation of four chemotherapy regimens for treatment of advanced AIDS-associated Kaposi sarcoma in Kenya: a cost-effectiveness analysis

Freeman, Esther E.; McCann, Nicole C; Semeere, Aggrey; Reddy, Krishna P.; Laker‐Oketta, Miriam; Byakwaga, Helen; Pei, Pamela P.; Fernandez, Maya E Hajny; Kiprono, Samson; Busakhala, Naftali; Martin, Jeffrey M.; Maurer, Toby; Bassett, Ingrid V.; Freedberg, Kenneth A.; Hyle, Emily P

doi:10.1016/s2214-109x(22)00242-x

Cited by 6 publications

(3 citation statements)

References 33 publications

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“…The authors found that these protocols resulted in favorable outcomes in terms of event-free survival and overall survival rates in this specific age group. Another international study by Freeman et al was a cost-effectiveness analysis of 4 chemotherapy regimens for advanced AIDS (acquired immunodeficiency syndrome)-associated Kaposi sarcoma in Kenya 46 . The authors found that paclitaxel-based regimens were the most cost-effective options and could provide meaningful clinical benefits while being affordable in resource-limited settings.…”

Section: Systemic Therapymentioning

confidence: 99%

What’s New in Musculoskeletal Tumor Surgery

Gazendam,

Ghert

2023

Journal of Bone and Joint Surgery

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Section: Systemic Therapymentioning

confidence: 99%

What’s New in Musculoskeletal Tumor Surgery

Gazendam,

Ghert

2023

Journal of Bone and Joint Surgery

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“…Yet, modeling can reveal the impact of therapies on life expectancy and their cost effectiveness to inform efficient allocation of resources. Given the high prevalence of HIV in SSA, modeling for AIDS-associated KS is particularly salient ( 390 ). In the same context, T-cell sparing treatments of KSHV associated diseases should be considered ( 391 ).…”

Section: Human Herpesvirus-8 or Kaposi Sarcoma-associated Herpesvirusmentioning

confidence: 99%

Malignancy and viral infections in Sub-Saharan Africa: A review

Diakité

Shaw‐Saliba²,

Lau³

2023

Front. Virol.

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The burden of malignancy related to viral infection is increasing in Sub-Saharan Africa (SSA). In 2018, approximately 2 million new cancer cases worldwide were attributable to infection. Prevention or treatment of these infections could reduce cancer cases by 23% in less developed regions and about 7% in developed regions. Contemporaneous increases in longevity and changes in lifestyle have contributed to the cancer burden in SSA. African hospitals are reporting more cases of cancer related to infection (e.g., cervical cancer in women and stomach and liver cancer in men). SSA populations also have elevated underlying prevalence of viral infections compared to other regions. Of 10 infectious agents identified as carcinogenic by the International Agency for Research on Cancer, six are viruses: hepatitis B and C viruses (HBV and HCV, respectively), Epstein-Barr virus (EBV), high-risk types of human papillomavirus (HPV), Human T-cell lymphotropic virus type 1 (HTLV-1), and Kaposi’s sarcoma herpesvirus (KSHV, also known as human herpesvirus type 8, HHV-8). Human immunodeficiency virus type 1 (HIV) also facilitates oncogenesis. EBV is associated with lymphomas and nasopharyngeal carcinoma; HBV and HCV are associated with hepatocellular carcinoma; KSHV causes Kaposi’s sarcoma; HTLV-1 causes T-cell leukemia and lymphoma; HPV causes carcinoma of the oropharynx and anogenital squamous cell cancer. HIV-1, for which SSA has the greatest global burden, has been linked to increasing risk of malignancy through immunologic dysregulation and clonal hematopoiesis. Public health approaches to prevent infection, such as vaccination, safer injection techniques, screening of blood products, antimicrobial treatments and safer sexual practices could reduce the burden of cancer in Africa. In SSA, inequalities in access to cancer screening and treatment are exacerbated by the perception of cancer as taboo. National level cancer registries, new screening strategies for detection of viral infection and public health messaging should be prioritized in SSA’s battle against malignancy. In this review, we discuss the impact of carcinogenic viruses in SSA with a focus on regional epidemiology.

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“…Allan Vinícius Martins-de-Barros [1], [2], [3]  , Marianne de Vasconcelos Carvalho [1], [2]  and Fábio Andrey da Costa Araújo [1], [3] …”

Section: Aids-related Kaposi Sarcoma Of the Oral Cavityunclassified