Evaluation of free-radical quenching properties of standard Ayurvedic formulation Vayasthapana Rasayana

Mukherjee, Sourav; Pawar, Nayana; Kulkarni, Omkar; Nagarkar, Bhagyashri; Thopte, Shrikant; Bhujbal, Akshay; Pawar, Pankaj K.

doi:10.1186/1472-6882-11-38

Cited by 61 publications

(38 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A linear correlation between DPPH scavenging activity and temperature variation showed a statistically significant correlation (R 2 = 0.8963) with natural (vitamin C; R 2 = 0.9691) and synthetic antioxidant (BHT; 0.8877). These data are in accordance with earlier research (Park et al 2009;Mukherjee et al 2011;Salar & Seasotiya 2011), suggesting that a high temperature does not influence antioxidant activity in K. alvarezii.…”

Section: Discussionsupporting

confidence: 83%

Investigation of the effect ofK. alvareziion antioxidant enzymes, cell viability and DNA damage in male rats

Nagarani

Kumaraguru

2012

Frontiers in Life Science

View full text Add to dashboard Cite

In recent years, a significant number of novel metabolites with potent pharmacological properties (antioxidant, antitumor, anti-HIV) have been discovered from marine organisms. Kappaphycus alvarezii (Doty) is a marine alga belonging to order: Gigartinales and family: Solieriaceae. It has been invasive in the Gulf of Mannar since 2000, and has a high content of the steroid phenol. This is the first report on its antioxidant properties using an animal model. This study aimed to explore the antioxidant and antigenotoxic/protective role of K. alvarezii growing in southeast coast of India in the male rat. The findings indicate that an extract of K. alvarezii is not nephrotoxic at the dose levels. The algal antioxidant activity shows similar correlation (89%; R 2 = 0.8963) at varying temperature to the known antioxidant. K. alvarezii extracts exhibit significant protective effects against DNA damage induced by H 2 O 2 , which might be related to antioxidant activity. In conclusion, our results suggest that long-term daily administration of K. alvarezii extract offers enhanced antioxidant potential and protection against tissue lipid peroxidation and cell damage. Our results support the use of K. alvarezii in the food and pharmaceutical industries.

show abstract

Section: Discussionsupporting

confidence: 83%

Investigation of the effect ofK. alvareziion antioxidant enzymes, cell viability and DNA damage in male rats

Nagarani

Kumaraguru

2012

Frontiers in Life Science

View full text Add to dashboard Cite

show abstract

“…The IC50 value was determined from the graph slope "y = mx + c" formula that obtained from the graph for standard trolox and mushroom extracts (Mukherjee et al, 2011).…”

Section: Preparation Of Sample [Mushroom Extract + Ethanol + Dpph] Symentioning

confidence: 99%

A Comparative Study on Antioxidant Properties and Metal Contents of Some Edible Mushroom Samples From Kastamonu, Turkey

Bakır¹,

Ünal²,

Karadeniz³

et al. 2017

J Food Health Sci

View full text Add to dashboard Cite

Abstract:In this work Pleurotus ostreatus, Agaricus bisporus and Lactarius delicious were used to determine and compare their antioxidant capacities and metal contents. The edible mushroom samples were collected from Kastamonu in the West Black Sea region of Turkey. The antioxidant capacity studies were performed by DPPH (1, 1diphenyl-2-picryl hydrazyl) radical scavenging method and were expressed as Trolox equivalents with spectroscopic measurements. TEAC (Trolox Equivalent Antioxidant Capacity) values were found 0.302, 0.557 and 0.251 µM/g for Pleurotus ostreatus, Lactarius delicious and Agaricus bisporus, respectively. All samples were analyzed by X-ray fluorescence (XRF) spectrometry to obtain the concentration of Cr, Mn, Fe, Ni, Cu, Zn, Ca, Pb, Na, Mg and K. While maximum and minumum metal contents of mushrooms were found as mg/g for Na (96-14.9), Mg (8.83-2.60), K (4.05-3.16), Ca (0.089-0.019) and Fe (0.128-0.099), the maximum and minumum contents of mushrooms were found for Cr (8-5), , Zn (7-3) and Pb (3-1) as mg/kg. Metal contents were determined together with antioxidant capacity of all analysed mushrooms. It was observed that although the Fe, Ni, Ca, Na, and Mg contents of Agaricus bisporus were lower, it had got higher inhibition than the other mushroom species.

show abstract

“…The Fe 3+ -reducing power of the extract was determined by a method described by Hazraet al [20]with slight modification [21]. The assay involved (i) mixing different concentrations ( …”

Section: Reducing Power Assaymentioning

confidence: 99%

Antioxidative and xanthine oxidase inhibitory activities and phytochemical screening of the hydro-alcoholic extract of mace, aril of Myristica fragrans: Implication as an adjuvant therapy in gout

Ullah

2016

International Journal of Food Properties

View full text Add to dashboard Cite

Myristica fragrans derivatives are used as spices in cuisines and also serve as an important source of traditional medicine worldwide. The present study has evaluated the anti-oxidative potential of the hydro-methanolic extract of the fruit aril of M. fragrans, which is also referred to as mace. This study also includes a quantitative phytochemical assessment of the extract and focuses on the ability of the extract to inhibit xanthine oxidase, a molecular target involved in nucleic acid metabolism and the enzyme responsible for the development of gout disease. The extract was found to contain different classes of secondary metabolites, including flavonoids, phenolics, tannins, alkaloids and saponins. Furthermore, the anti-oxidative potential of the extract was evaluated against the radicals ABTS and DPPH, and there was a progressive reduction of the radicals with increasing doses of the extract. Moreover, a ferric reducing power assay also showed the antioxidant activity of the crude extract as compared to ascorbic acid, a well-known antioxidant. Another significant finding of the study is that the mace extract also considerably inhibits the enzyme xanthine oxidase in a concentration-dependent manner. Our A c c e p t e d M a n u s c r i p t 2 results partially support the use of mace in dietary regimens as a nutraceutical that could serve as a prophylactic strategy or an adjuvant for the prevention and therapy of gout disease.

show abstract

Evaluation of free-radical quenching properties of standard Ayurvedic formulation Vayasthapana Rasayana

Cited by 61 publications

References 17 publications

Investigation of the effect ofK. alvareziion antioxidant enzymes, cell viability and DNA damage in male rats

Investigation of the effect ofK. alvareziion antioxidant enzymes, cell viability and DNA damage in male rats

A Comparative Study on Antioxidant Properties and Metal Contents of Some Edible Mushroom Samples From Kastamonu, Turkey

Antioxidative and xanthine oxidase inhibitory activities and phytochemical screening of the hydro-alcoholic extract of mace, aril of Myristica fragrans: Implication as an adjuvant therapy in gout

Contact Info

Product

Resources

About