Evaluation of Gastroprotective Activity of Qarahine: A Polyherbal Formulation

An imbalance in the aggressive factors and protective factors in the gastrointestinal tract leads to peptic ulcers. Modern medicinal prescriptions for ulcers involve the use of allopathic drugs. However, several disadvantages, such as side effects, discordancy, and altered physiological aspects, have led to the quest for alternative safer medications. The use of herbs to treat ulcers has been practiced for decades in Ayurveda. A combination of such herbs, known as polyherbal formulation, shows several advantages like synergistically augmented beneficial effects, better patient compliance, and reduction in dose of individual drugs without compromising the therapeutic effects. In recent years, this valuable traditional knowledge of the medicinal values of herbs, along with current value-added developments, has ensured the usage of improved Ayurvedic medicine in a milieu of treatments. In the last two decades, many polyherbal formulations have been developed and evaluated for their antiulcer potential. The advancements in analytical methods have even led to the isolation of the phytoconstituents from crude herbal drugs, and their benefits in therapeutics have been studied. The core aim of the current review is to enlighten the comprehensive overview of the composition of some marketed antiulcer polyherbal formulations and the preclinical models to prove their gastroprotective potentials based on scientific findings.

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“…Diminution of the number of lesions, the severity of the injury, and ulcer index was found to be substantial as compared to control. 24…”

Section: Qarahinementioning

confidence: 99%

Comprehensive Review of the Marketed Antiulcer Polyherbal Formulations

Gupta

Khade

Srivastava

et al. 2022

Int J Life Sci Pharm Res

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“…5 It is well known that crude herbs have been used as folklore medication for centuries. 6 A tremendous amount of society still depends on traditional medications for their regular healthcare requirements. 7 Among the alternate medicines, plant-origin drugs are the most preferred sources due to their relatively low cost, adverse effects, and toxicity with high efficacy in treating ulcers.…”

Section: Introductionmentioning

confidence: 99%

Comparative Antioxidant and Antiulcer Potential of In-house and Marketed Polyherbal Formulation

Khade¹,

Gupta²,

Srivastava³

et al. 2022

IJDDT

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The prime objective of the present research was to assess the antioxidant and comparative anti-ulcer potential of a gastroretentive polyherbal formulation with a conventional oral marketed formulation. The antioxidant capacity was estimated by 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) and 2,2-diphenylpicrylhydrazyl (DPPH) methods. For the assessment of comparative anti-ulcer potential, the aspirin-induced rat ulcer model was utilized. Enzyme-linked immunosorbent assay (ELISA) studies were performed to study the effect on pro- and anti-inflammatory markers. ABTS and DPPH free radical scavenging capacity signified the antioxidant activity of the formulation. Evaluation parameters such as pH of the gastric content, total and free acidity, ulcer index, and histopathological changes were studied in the aspirin-induced anti-ulcer activity. The study’s outcomes reveal the significant anti-ulcer potential of the in-house gastro-retentive polyherbal formulation and marketed formulation as indicated by the reduction in ulcer index, free and total acidity. The results of the histopathological investigation further strengthened the anti-ulcer potential. Moreover, pre-treatment with gastro-retentive formulation decreased the ulcer index to a greater degree than the conventional marketed formulation. The results conclude that the antioxidant, antisecretory, cytoprotective, and anti-inflammatory actions might be responsible for the anti-ulcer activity. Further, the gastro-retentive formulation has an improved potential in treating ulcers over conventional oral formulations.

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Evaluation of Gastroprotective Activity of Qarahine: A Polyherbal Formulation

Cited by 2 publications

References 9 publications

Comprehensive Review of the Marketed Antiulcer Polyherbal Formulations

Comprehensive Review of the Marketed Antiulcer Polyherbal Formulations

Comparative Antioxidant and Antiulcer Potential of In-house and Marketed Polyherbal Formulation

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