Evaluation of gastroprotective and ulcer healing activities of yellow mombin juice from Spondias mombin L.

Abstract

Spondias mombin L. (yellow mombin) is a tree with a nutritional fruit that is commonly consumed in the North and Northeast of Brazil, as the juice of its pulp is rich in antioxidant compounds. This study aimed to investigate the gastroprotective and ulcer healing activities of yellow mombin juice (YMJ) in Wistar rats, and to elucidate the possible involved mechanisms. Phytochemical characterization of the lyophilized fruit juice was performed by high-performance liquid chromatography (HPLC). The gastroprotective activity of YMJ was investigated in ethanol (25, 50, and 100% YMJ) and indomethacin (100% YMJ) models of acute gastric ulcer in rats. Then, the effect of YMJ on mucus production and gastric secretions, and the involvement of non-protein sulfhydryl groups and prostaglandins in the gastroprotective process were examined. Moreover, the ulcer healing effect of YMJ was investigated in a model of acetic acid-induced chronic ulcer through histological and immunohistochemical analyses. HPLC results identified the presence of epicatechin (7.1 ± 1.6 μg/mL) and quercetin (17.3 ± 2.5 μg/mL) in YMJ. Ethanol-induced gastric lesions were inhibited by YMJ (25, 50, and 100%) by 42.42, 45.09, and 98.21% respectively, and indomethacin-induced lesions were inhibited by YMJ (100%) by 58.96%, compared to control group. Moreover, YMJ reduced gastric content and total acidy by 57.35 and 71.97%, respectively, compared to the control group. Treatment with YMJ also promoted healing of chronic ulcer, regeneration of the gastric mucosa, and restoration of mucus levels in glandular cells, as confirmed by histological analysis. It also increased cellular proliferation, as demonstrated by high reactivity to Ki-67 and bromodeoxyuridine. In conclusion, YMJ was found to possess gastroprotective and ulcer healing activities that are correlated to its antisecretory action. These results support the commercial exploration of YMJ as a functional food.

Tablet of Spondias mombin L. Developed from Nebulized Extract Prevents Gastric Ulcers in Mice via Cytoprotective and Antisecretory Effects

“…These results are in agreement with studies by [ 34 ], who demonstrated the safety of using S. mombin extracts in rodents.…”

“…When administered intraduodenally, SmNE showed antisecretory activity, in which a reduction in the volume and weight of gastric content and an increase in pH can be observed, suggesting that antisecretory activity may contribute to the gastroprotection conferred to the extract. The results obtained corroborate those obtained by [ 34 ], in which the juice of the fruits of S. mombin —which is a 100% solution—also showed anti-secretory activity.…”

“…It has proven antimutagenic, anti-inflammatory, and antioxidant activities [ 33 ]. Previous studies by [ 34 ], demonstrated the presence of gallic acid and ellagic acid in the ethanolic extract of S. mombin leaves.…”

Proposta de reconstituição da flora e geração de renda aos locais afetados pelo rompimento da barragem de Fundão

“…Todas as partes da árvore são de grande importância medicinal, a exemplo destacam-se os frutos e as folhas. Os frutos apresentam efeitos diuréticos (ELUFIOY et al, 2017), atividades gastroprotetoras e cicatrizantes de úlceras (BRITO et al, 2018). Já as folhas são apontadas por sua atividade contra o vírus da dengue (AJAEGBU et al, 2016), tratamento da doença de Alzheimer (ELUFIOYE et al, 2017), além de atividade antioxidante e anti-inflamatória (GOMES et al, 2020).…”

Fermented yellow mombin juice using Lactobacillus acidophilus NRRL B-4495: Chemical composition, bioactive properties and survival in simulated gastrointestinal conditions

“…It is rich in carbohydrates (13.9 g/100 g), proteins (1.1 g/100 g), fibers (1.9 g/100 g), pro-vitamin A (223.0 RE/100 g), β-criptoxanthin (1708.5 μg/100 g), lutein (634.0 μg/100 g), zeinoxanthin (547.5 μg/ 100 g), β-carotene (314.0 μg/100 g), phenolic compounds (260.2 mg GAE/100 g), magnesium (15.1 mg/100 g), phosphorous (32.8 mg/100 g), potassium (288.3 mg/100 g) and calcium (11.0 mg/100 g) [19]. This unique composition has shown antioxidant effects [19], gastroprotective and ulcer healing activities [20], attenuation of ventricular remodeling after myocardial infarction [21], and cytotoxic effects on ovarian cancer cells [22].…”