Evaluation of genetic and epigenetic changes of Tumor Necrosis Factor-Alpha gene in larynx cancer

Transcriptional subtypes of glottic cancer characterized by differential activation of canonical oncogenic programming

“…This empirical data, however, has not been, or has not been able to be, leveraged to affect clinical outcomes—a recent Surveillance, Epidemiology, and End Results (SEER) analysis, for example, stipulated a 25% relative increase in case‐fatality rate between 1986 and 2016, based on a larynx cancer dataset wherein the majority of tumors were of glottic origin 12 . Though a few published efforts to systematically sequence the laryngeal cancer genome have led to the identification of discrete genetic perturbations, 13–15 the complex interplay between the wide spectrum of tumor molecular features and both patient‐centric and disease‐centric clinical characteristics necessitates a deeper, coherent approach to understand the functional consequences of these genetic alterations to guide improvements in GSCC treatment and prognostication. Moreover, investigations into prognostic molecular changes among laryngeal cancers that group all subsites together neglect the potentially disparate clinical implications and heterogenous downstream effects of these genetic perturbations; in fact, studies have identified significant molecular differences among tumors originating from the different laryngeal subsites 13 …”