Evaluation of genetic damage in operating room personnel exposed to anaesthetic gases

Chandrasekhar, M.; Rekhadevi, Perumalla V.; Sailaja, N.; Rahman, M. F.; Reddy, J. P.; Mahboob, M.; Grover, Paramjit

doi:10.1093/mutage/gel029

Cited by 70 publications

(59 citation statements)

References 31 publications

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“…Many studies have suggested that chronic exposure to trace levels of anesthetic gas is harmful to operating room personnel despite developed scavenging systems [2,[17][18][19][20]. To our knowledge, this is the first study to interpret the association between impaired oxidative balance and HDL-related PON1, ARE enzyme activity, and AP.…”

Section: Discussionmentioning

confidence: 79%

Arylestarase and Oxidative Stress in Operating Room Personnel

Cerit¹,

Onuk²,

Elli̇dağ³

et al. 2014

Adv Clin Exp Med

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Background. Long-term occupational exposure to trace concentrations of volatile anesthetics is known to have adverse effects on the health of exposed personnel. Objectives. We investigated paraoxonase-1 (PON1) and arylesterase (ARE), as well as antioxidant status (TAS) and total oxidant status (TOS) levels in anesthesia personnel (AP) who were chronically exposed to inhalation anesthetics, and compared them with levels in a control group. Material and Methods. We designed a comparative prospective study with 50 female subjects. The first cohort included 25 full-time female workers in operating rooms in two locations in the Antalya Education and Research Hospital in Antalya, Turkey. The control group was comprised of 25 female individuals working in the same hospitals without any work-related exposure to hazardous agents. Results. Serum ARE activity and TAS levels were significantly reduced (p = 0.04 and p < 0.0001, respectively), whereas TOS and OSI levels were found to be significantly higher (p = 0.01 and p < 0.0001, respectively) in AP. However, there were no significant differences in PON1 activity, PON1/HDL-C, ARE/HDL-C, and PON1/ /ARE (p = 0.30, p = 0.5, p = 0.1 and p = 0.7, respectively) when the two groups were contrasted. Conclusions. According to the results of this study, depending on the putative role of PON/ARE in oxidant stress--related diseases, particularly atherosclerosis and cancer, AP might be considered a risk group for the development of atherosclerosis and many other diseases (Adv Clin Exp Med 2014, 23, 1, 49-55).

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Section: Discussionmentioning

confidence: 79%

Arylestarase and Oxidative Stress in Operating Room Personnel

Cerit¹,

Onuk²,

Elli̇dağ³

et al. 2014

Adv Clin Exp Med

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“…Wiesner et al found a higher MN level in anaesthesiologists and nurses exposed to high levels of halothane and isoflurane compared with a control group 1) . Chandrasekhar et al reported a statistically significant increase in DNA damage as shown by CA, MN and the comet assay in operating room personnel exposed to anaesthetic gases 16) . Although we couldn't evaluate the exposure levels to anaesthetic gases, our study points to an increase in DNA damage in anaesthesia nurses working in operating rooms with artificial ventilation and active scavenging systems.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Genotoxic Damage in Nurses Occupationally Exposed to Anaesthetic Gases or Antineoplastic Drugs by the Comet Assay

İzdeş¹,

Şardaş

Kadıoğlu

et al. 2009

Journal of Occupational Health

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“…Studies have shown increased DNA damage, assessed by sister chromatid exchange (SCE), chromosomal aberration (CA) and micronuclei (MN) tests in operating room personnel exposed for several years to waste anesthetic gases [10][11][12][13][14][15][16][17] . However, there is still no report about the effect of waste anesthetic gases in professionals occupationally exposed for a shorter time.…”

Section: Introductionmentioning

confidence: 99%

DNA damage and antioxidant status in medical residents occupationally exposed to waste anesthetic gases

et al. 2014

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PURPOSE:To investigate the effects of occupational exposure to waste anesthetic gases on genetic material and antioxidant status in professionals during their medical residency. METHODS:The study group consisted of 15 medical residents from Anesthesiology and Surgery areas, of both genders, mainly exposed to isoflurane and to a lesser degree to sevoflurane and nitrous oxide; the control group consisted of 15 young adults not exposed to anesthetics. Blood samples were drawn from professionals during medical residency (eight, 16 and 22 months of exposure to waste anesthetic gases). DNA damage was evaluated by comet assay, and antioxidant defense was assessed by total thiols and the enzymes glutathione peroxidase (GPX), superoxide dismutase (SOD) and catalase (CAT). RESULTS:When comparing the two groups, DNA damage was significantly increased at all time points evaluated in the exposed group; plasma thiols increased at 22 months of exposure and GPX was higher at 16 and 22 months of exposure.CONCLUSION: Young professionals exposed to waste anesthetic gases in operating rooms without adequate scavenging system have increased DNA damage and changes in redox status during medical residency. There is a need to minimize exposure to inhalation anesthetics and to provide better work conditions.

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Evaluation of genetic damage in operating room personnel exposed to anaesthetic gases

Cited by 70 publications

References 31 publications

Arylestarase and Oxidative Stress in Operating Room Personnel

Arylestarase and Oxidative Stress in Operating Room Personnel

Assessment of Genotoxic Damage in Nurses Occupationally Exposed to Anaesthetic Gases or Antineoplastic Drugs by the Comet Assay

DNA damage and antioxidant status in medical residents occupationally exposed to waste anesthetic gases

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