Evaluation of genotoxic effects induced by exposure to antineoplastic drugs in lymphocytes and exfoliated buccal cells of oncology nurses and pharmacy employees

Cavallo, Delia; Ursini, Cinzia Lucia; Perniconi, Barbara; Francesco, A. Di; Giglio, Margherita; Rubino, Federico Maria; Marinaccio, Alessandro; Iavicoli, Sergio

doi:10.1016/j.mrgentox.2005.07.008

Cited by 103 publications

(70 citation statements)

References 27 publications

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“…[24][25][26] Indeed, transient increases of SCEs and micronuclei (MNs) in cases of accidental contamination, 23 as well as significantly increased rates of SCEs, CAs and MNs in occupationally exposed nurses, were observed. 24,27,28 Although previous published studies have demonstrated a significant increase of CAs among hospital workers occupationally exposed to drugs, 24,27,29,30 in the present study, no chromosomal damage, in terms of increase of the CAs and CAB frequencies, was observed among our nurses sample.…”

Section: Discussioncontrasting

confidence: 73%

Chromosomal damage in peripheral blood lymphocytes from nurses occupationally exposed to chemicals

2013

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In the present study, we evaluated the induced genome damage in peripheral blood lymphocytes from a sample of nurses occupationally exposed to low doses of different chemicals. A comprehensive multi-biomarker approach using cytogenetic endpoints was employed for analyzing chromosomal aberrations (CAs) and sister chromatid exchange (SCE) assay. The study included 20 nurses and 20 control subjects matched in age, gender and smoking habits. Nurses were exposed to different chemicals, such as cytostatic drugs, anaesthetics, formaldehyde and other sterilizing gases. Significant differences were found between exposure group and control group in terms of SCEs frequency ( p < 0.001) but not in terms of replication index value ( p = 0.845) and CAs ( p = 0.236). Regression analyses indicated that the age and the exposure years did not influence the amount of the chromosomal damage among nurses. Vice versa, among controls, a positive correlation was found between the number of SCEs and age. In conclusion, our results suggest that a continuous long-term exposure to low doses of chemicals could result in increased levels of SCEs among nurses. This data emphasize the importance of biomonitoring nurses and other hospital workers handling drugs.

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Section: Discussioncontrasting

confidence: 73%

Chromosomal damage in peripheral blood lymphocytes from nurses occupationally exposed to chemicals

2013

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“…Additionally, most of these samples were from the administration units. Our results can be explained once again by the fact that there are more strict safety and hygiene rules in preparation units when compared with administration units as demonstrated by the high number of organizations that research on this field developing constantly new rules and safety measures (ISOPP 2007;NIOSH among others). This raises attention to another important aspect that should be considered for the risk assessment process: in this setting, exposure is characterized by being simultaneous to different antineoplastic drugs and the health effects of such mixtures are unpredictable (Fucic et al 1998;Cavallo et al 2005;Kopjar et al 2009). …”

Section: Discussionmentioning

confidence: 99%

Antineoplastic drugs contamination of workplace surfaces in two Portuguese hospitals

Viegas

Pádua

Veiga

et al. 2014

Environ Monit Assess

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Despite the classification as known or suspected human carcinogens, by the International Agency for Research on Cancer, the antineoplastic drugs are extensively used in cancer treatment due to their specificity and efficacy. As human carcinogens, these drugs represent a serious threat to the healthcare workers involved in their preparation and administration. This work aims to contribute to better characterize the occupational exposure of healthcare professionals to antineoplastic drugs, by assessing workplace surfaces contamination of pharmacy and administration units of two Portuguese hospitals. Surface contamination was assessed by the determination of cyclophosphamide, 5-fluorouracil, and paclitaxel. These three drugs were used as surrogate markers for surfaces contamination by cytotoxic drugs. Wipe samples were taken and analyzed by HPLC-DAD. From the total of 327 analyzed samples, in 121 (37 %) was possible to detect and quantify at least one drug. Additionally, 28 samples (8.6 %) indicate contamination by more than one antineoplastic drug, mainly in the administration unit, in both hospitals. Considering the findings in both hospitals, specific measures should be taken, particularly those related with the promotion of good practices and safety procedures and also routine monitoring of surfaces contamination in order to guarantee the appliance of safety measures.

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“…19 Previous studies have demonstrated evidence of the mutagenicity of antineoplastic drugs through various biomarkers. [20][21][22] In a study correlating occupational exposure to adverse health outcomes, Fransman and others 23 found a positive log-linear relation between dermal exposure to antineoplastic drugs and risk of premature delivery and low birth weight in a cohort of oncology nurses. In a recent study, McDiarmid and others 24 found genetic abnormalities among oncology personnel who were handling anticancer drugs.…”

Section: Discussionmentioning

confidence: 99%

Pilot Evaluation of Dermal Contamination by Antineoplastic Drugs among Hospital Pharmacy Personnel

Hon

Astrakianakis

Danyluk

et al. 2011

CJHP

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Evaluation of genotoxic effects induced by exposure to antineoplastic drugs in lymphocytes and exfoliated buccal cells of oncology nurses and pharmacy employees

Cited by 103 publications

References 27 publications

Chromosomal damage in peripheral blood lymphocytes from nurses occupationally exposed to chemicals

Chromosomal damage in peripheral blood lymphocytes from nurses occupationally exposed to chemicals

Antineoplastic drugs contamination of workplace surfaces in two Portuguese hospitals

Pilot Evaluation of Dermal Contamination by Antineoplastic Drugs among Hospital Pharmacy Personnel

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