2018
DOI: 10.14260/jemds/2018/979
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Evaluation of Gingival Crevicular Fluid Alkaline Phosphatase in Postmenopausal Women Treated With Subgingival Simvastatin

Abstract: BACKGROUND Women at menopause are found to be at risk for decreased bone density and chronic periodontitis due to oestrogen deficiency and common risk factors. Statins have anti-inflammatory and anti-resorptive properties and are successfully used in postmenopausal osteopenia. Increased alkaline phosphatase activity is observed in periodontitis. Thus, 1.2 mg Simvastatin gel was used subgingivally in this study. The level of alkaline phosphatase was evaluated in the sites treated as a biomarker. MATERIALS AND M… Show more

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