Evaluation of Glutathione S-Transferase P1 Polymorphisms (Ile105Val and Ala114Val) in Patients with Small Cell Lung Cancer

Vural, Burçak; Yakar, Fatih; Derin, Duygu; Saip, Pınar; Yakar, Aysun; Demirkan, Ayşe; Karabulut, Aydın; Uğurel, Elif; Çine, Naci; Kılıçaslan, Zeki; Tüzün, Erdem; Özbek, Uğur

doi:10.1089/gtmb.2011.0315

Cited by 8 publications

(6 citation statements)

References 32 publications

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“…Moreover, the single nucleotide polymorphism at the GSTP1 loci results in an amino acid substitution that leads to reduced activity, which may alter susceptibility to cancer. Since Harris et al (1998) first examined the association between the GSTP1 341C/T polymorphism and the risk of lung cancer, a number of other studies have been conducted to evaluate the role of the 341C/T polymorphism in the GSTP1 gene on lung cancer risk (Wang et al, 2003;Yang et al, 2004;Zienolddiny et al, 2008;Vural et al, 2012). However, the results remain conflicting rather than conclusive.…”

Section: Discussionmentioning

confidence: 99%

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The 341C/T polymorphism in the GSTP1 gene and lung cancer risk: a meta-analysis

Yan

Wang²,

Geng

2016

Genet. Mol. Res.

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ABSTRACT. Numerous studies have evaluated the association between the 341C/T polymorphism in glutathione S-transferase P1 (GSTP1) and lung cancer risk. However, there are conflicting results from previous studies. To derive a more precise estimation of the association, we conducted this meta-analysis. A comprehensive search was conducted to identify the eligible studies examining the GSTP1 341C/T polymorphism and lung cancer risk. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. The meta-analysis results showed that the GSTP1 341C/T polymorphism was significantly associated with lung cancer risk (TT GSTP1 341C/T polymorphism may contribute to lung cancer risk. Conclusive evidence on the effects of this variant in lung cancer should be addressed in further studies.

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Section: Discussionmentioning

confidence: 99%

“…Through screening the title and reading the abstract/article, 5 eligible articles were selected for this meta-analysis (Harris et al, 1998;Wang et al, 2003;Yang et al, 2004;Zienolddiny et al, 2008;Vural et al, 2012). The detailed screening process is shown in Figure 1.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

The 341C/T polymorphism in the GSTP1 gene and lung cancer risk: a meta-analysis

Yan

Wang²,

Geng

2016

Genet. Mol. Res.

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“…The polymorphisms in GSTM1 and GSTT1 have been investigated in cancer for a long time; however, only recently have some studies investigated the association of various cancers with GSTP1 variants. Some studies have observed a different relation between the GSTP1 polymorphism and an increased risk for oral [17], breast [15], [18], colorectal [19], prostate [20] and lung [21], [22] cancers. Regarding gastric cancer, only a few studies were conducted to investigate its association with GSTP1 variants [23].…”

Section: Introductionmentioning

confidence: 99%

Interaction between GSTP1 Val Allele and H. pylori Infection, Smoking and Alcohol Consumption and Risk of Gastric Cancer among the Chinese Population

et al. 2012

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Glutathione S-transferase P1 (GSTP1) is a critical enzyme in the phase II detoxification pathway. One of the common functional polymorphisms of GSTP1 is A→G at nucleotide 313, which results in an amino acid substitution (Ile105Val) at the substrate binding site and reduced catalytic activity. We evaluated the interaction between GSTP1 Val allele and Helicobacter pylori infection, smoking and alcohol consumption, increasing the risk of gastric cancer among the Chinese population. Information on potential gastric cancer risk factors and blood specimens were collected from 618 incident gastric cancer cases and 1,830 non-cancer controls between March 2002 and December 2011 in Liaoning Province, China. GSTP1 Ile105Val was genotyped by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and polymerase chain reaction-restriction fragment length polymorphism. Serum levels of anti-H. pylori IgG were measured by ELISA. Odds ratio (OR) and 95% confidence interval (CI) were calculated using multivariate logistic regression, adjusted by sex and age. The risk of gastric cancer was significantly elevated in patients with the GSTP1 Val/Val genotype (adjusted OR = 3.324; 95% CI = 1.790–6.172). An elevated risk of gastric cancer was observed in patients with H. pylori infection, smoking, or alcohol consumption, and together with the GSTP1 Ile/Val +Val/Val genotype (OR = 3.696; 95% CI = 2.475–5.521; OR = 1.638; 95% CI = 1.044–2.571; OR = 1.641; 95% CI = 0.983–2.739, respectively) (p<0.05). The GSTP1 Val allele shows an interaction with smoking, alcohol consumption, and especially H. pylori infection for increasing the risk of gastric cancer. These findings could demonstrate new pathophysiological pathways for the development of gastric cancer.

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“…This group did not provide evidence for a strong association between GSTP1 rs1138272 and lung cancer susceptibility (Ye et al, 2006). Yan et al (2016) included five case-control studies (Harris et al, 1998; Wang et al, 2003; Yang et al, 2004; Zienolddiny et al, 2008; Vural et al, 2012) to perform another relative meta-analysis (Yan et al, 2016) wherein an association between GSTP1 rs1138272 and increased lung cancer risk was detected (Yan et al, 2016). Here, in our subgroup analysis of lung cancer, we removed one study that was not in HWE (Vural et al, 2012) and added two case-control studies (Saarikoski et al, 1998; Minina et al, 2017) for the pooled analysis.…”

Section: Discussionmentioning

confidence: 99%

“…Yan et al (2016) included five case-control studies (Harris et al, 1998; Wang et al, 2003; Yang et al, 2004; Zienolddiny et al, 2008; Vural et al, 2012) to perform another relative meta-analysis (Yan et al, 2016) wherein an association between GSTP1 rs1138272 and increased lung cancer risk was detected (Yan et al, 2016). Here, in our subgroup analysis of lung cancer, we removed one study that was not in HWE (Vural et al, 2012) and added two case-control studies (Saarikoski et al, 1998; Minina et al, 2017) for the pooled analysis. Based on the available data within seven articles (Harris et al, 1998; Saarikoski et al, 1998; Wang et al, 2003; Sorensen et al, 2004; Yang et al, 2004; Zienolddiny et al, 2008; Minina et al, 2017), we failed to detect a relationship between GSTP1 rs1138272 and lung cancer risk in the overall population.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Analysis of the Association Between the rs1138272 Polymorphism of the GSTP1 Gene and Cancer Susceptibility

Ding

Zhang

et al. 2019

Front. Physiol.

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Background: We obtained conflicting results regarding the relationship between the genetic role of the rs1138272 C/T polymorphism of the GSTP1 (Glutathione S-Transferase pi) gene and the risk of various cancers.Methods: Using the presently available data, a meta-analysis was conducted to comprehensively evaluate the genetic relationship between the GSTP1 rs1138272 polymorphism and cancer susceptibility.Results: A total of 43 studies including 15,688 cases and 17,143 controls were recruited into our quantitative synthesis. In the overall population, we observed an increased risk of overall cancer cases, compared with unrelated controls, in the genetic models of allele T vs. allele C (P-association = 0.007, OR = 1.17), carrier T vs. carrier C (P-association = 0.035, OR = 1.11), TT vs. CC (P-association = 0.002, OR = 1.45), TT vs. CC+CT (P-association = 0.009, OR = 1.42), and CT+TT vs. CC (P-association = 0.027, OR = 1.13). We detected similar positive results within the Asian population. Additionally, there was a significant increase in the incidence of cancer for Africans under all genetic models (all P-association < 0.05, OR > 1). When targeting the Caucasian population, we detected a positive association with the TT vs. CC and TT vs. CC+CT models in the “Colorectal cancer” (P-association < 0.05, OR < 1) and “Head and neck cancer” (P-association < 0.05, OR > 1) subgroups. For the “Lung cancer” subgroup, we observed a slightly increased risk in Caucasians under the models of allele T vs. allele C, carrier T vs. carrier C, CT vs. CC, and CT+TT vs. CC (P-association < 0.05, OR > 1).Conclusion: The TT genotype of the GSTP1 rs1138272 polymorphism is likely related to the susceptibility to overall cancer in the Asian and African populations and, specifically, “Colorectal” and “Head and neck” cancers in the Caucasian population. In addition, the CT genotype of the GSTP1 rs1138272 polymorphism may be linked to the risk of lung cancer in Caucasians. Additional evidence is required to confirm this conclusion.

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Evaluation of Glutathione S-Transferase P1 Polymorphisms (Ile105Val and Ala114Val) in Patients with Small Cell Lung Cancer

Abstract: The variant GSTP1 exon 6 genotype might be conferring protection against SCLC development. Whether this effect is associated with exposure to cigarette smoking needs to be clarified.

Cited by 8 publications

References 32 publications

The 341C/T polymorphism in the GSTP1 gene and lung cancer risk: a meta-analysis

The 341C/T polymorphism in the GSTP1 gene and lung cancer risk: a meta-analysis

Interaction between GSTP1 Val Allele and H. pylori Infection, Smoking and Alcohol Consumption and Risk of Gastric Cancer among the Chinese Population

Comprehensive Analysis of the Association Between the rs1138272 Polymorphism of the GSTP1 Gene and Cancer Susceptibility

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