Evaluation of Glyceryl Guaiacolate as a Muscle Relaxant in Buffalo Calves

Singh, Jit; Sobti, V. K.; Kohli, R. N.; Kumar, V. Rama; Khanna, Arun

doi:10.1111/j.1439-0442.1981.tb01163.x

Cited by 7 publications

(3 citation statements)

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“…Similar findings were observed by Rings and Muir (1982) in calves and Ninu et al (2015) after ketamine administration. This was in contrary to the findings in buffalo calves under guaifenesin anesthesia (Sarma and Kumar, 1998;Singh et al, 1981), midazolam-ketamine (Kumar et al, 2014b) and xylazine-ketamine (Singh et al, 2011) where corneal reflexes were completely abolished.…”

Section: Methodscontrasting

confidence: 65%

Anesthetic effects of ketamine-guaifenesin and isoflurane anesthesia for diaphragmatic herniorrhaphy in buffaloes

et al. 2022

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The study was undertaken on twelve buffaloes weighing 313 to 442 kg and age between 4 to 9 years to evaluate double drip of ketamine-guaifenesin and isoflurane anaesthesia for diaphragmatic herniorrhaphy. In Group I and II animals, anesthesia was induced with double drip of ketamine-guaifenesin (1000 mg of ketamine, 25 gm of guaifenesin in 500 ml Dextrose 5% solution) 1.5 ml/kg body weight. Double drip 2.5 mL/kg/h in Group I and 2 % isoflurane in Group II was used for maintenance of anaesthesia. In both the groups, quality of induction of anaesthesia was good to excellent. The quality of maintenance was assessed by analgesia, muscle relaxation, corneal reflexes, palpebral reflexes, and position of eyeball. Four animals in each group showed excellent muscle relaxation and two animals showed good muscle relaxation during the observation period. Analgesia was excellent in both the groups. In Group I three animals showed smooth and fast recovery whereas smooth and prolonged in rest of the animals. In Group II, all the animals showed smooth and fast recovery. The combination was found suitable for diaphragmatic herniorrhaphy in buffaloes.

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Section: Methodscontrasting

confidence: 65%

Anesthetic effects of ketamine-guaifenesin and isoflurane anesthesia for diaphragmatic herniorrhaphy in buffaloes

et al. 2022

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“…Alterations in the P5, due to the variations in ligands mentioned earlier result in the shift of the oxygen dissociation curve which is of great physiological significance. We have previously observed the development of alkalosis and possible tissue hypoxia during various stress conditions in cattle and buffaloes which is contrary to the observations made in monogastric animals (7)(8)(9)(10) teristic feature in these animals was the maintenance of oxygen saturation of haemoglobin. In such situations, as a result of acid base disturbances, the Bohr effect may operate to impair oxygen availability to tissues since, normally, advantage gained by increased affinity of haemoglobin for oxygen at pulmonary level is compromised by decreased oxygen delivery to the tissues.…”

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confidence: 70%

Oxygen Unloading Potential in Bovines in Health and Stress

Singh

Kohli

1980

Zentralblatt für Veterinärmedizin Reihe A

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Summary Oxygen unloading potential (P50) in normal healthy cow calves and buffalo calves was observed to be 26.9 mm. Hg (26.0–29.6 mm. Hg) and 26.2 mm. Hg (24.2–27.5 mm. Hg), respectively. These values were determined from blood pH, pO2, oxygen saturation and base excess. The P50 values were similarly determined in calves following septic shock and uraemia and in buffalo calves under septic shock and after glyceryl guaiacolate administration. The P50 values decreased in uraemic calves and buffalo calves under shock but remained unaffected in the remaining animals. Findings revealed that pCO2 is not specific in shifting the oxygen dissociation curve in bovines, but rather that it interacts with blood pH and other ligands. No correlation could be found between body temperature and the P50 values. Under certain physiopathological conditions, increased base excess in bovines may be disadvantageous as far as oxygen availability to the tissues is concerned. Zusammenfassung Das Sauerstoffabgabevermögen des Hämoglobins bei gesunden und unter Streß stehenden Boviden Bei gesunden Rindern und Büffelkälbern wurde die O2‐Spannung (pO2) für eine 50% O2‐Sättigung des Hämoglobins (P50) bestimmt. Der P50 betrug bei Rinderkälbern 26,9 mm Hg (26,0–29,6 mm Hg) und bei Büffelkälbern 26,2 mm Hg (24,2–27,5 mm Hg). Diese Werte wurden aufgrund des pH, des pO2, der O2‐Sättigung und des Basenüberschusses bestimmt. In analoger Weise wurde der P50 bei Rinderkälbern mit septikämischem Schock und Urämie sowie bei Büffelkälbern mit septikämischem Schock und nach Verabreichung von Glycerolguaiakolat erhoben. Bei Rinderkälbern mit Urämie und Büffelkälbern mit septikämischem Schock sank der P50, bei den übrigen Tieren veränderte sich der P50 nicht. Die Befunde zeigen, daß der pCO2 bei Boviden keinen spezifischen Faktor für die Verschiebung der O2‐Dissoziationskurve darstellt, vielmehr beeinflußt der pCO2 den pH des Blutes sowie andere Faktoren. Zwischen der Körpertemperatur und dem P50 konnte keine Korrelation gefunden werden. Unter gewissen pathologischen Zuständen scheint eine Erhöhung der Pufferbasen (Basenüberschuß) bei Boviden die O2‐Utilisation der Gewebe zu beeinträchtigen. Résumé Capacité de distribution d'oxygène de l'hémoglobine chez des bovins sains et stressés On a déterminé la tension d'O2 (pO2) pour une saturation à 50% de l'hémoglobine chez des veaux de bovins et de buffles sains. Le P50 comprenait 26,9 mm Hg (26,0–29,6 mm Hg) chez les veaux de bovins et 26,2 mm Hg (24,2–27,5 mm Hg) chez les veaux de buffles. Ces valeurs furent déterminées sur la base du pH, du pO2, de la saturation en O2 et de l'excès basique. On a relevé de la même manière la P50 chez des veaux de bovins atteints de choc septicémique et d'urémie et chez des veaux de buffles atteints de choc septicémique et après application de glycéroguaiacolate. Le P50 fut abaisse chez des veaux de bovins atteints d'urémie et des veaux de buffles souffrant de choc septicémique et ne changea pas chez les autres animaux. Les résultats montrent que le pCO2 chez les bovins ne représe...

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“…E. R. decreased non-significantly, but an alarming reduction in these values occurred at one or other interval in individual animals. Since the time 50.0 t 9.5 113.2 f. 10…”

Section: Resultsmentioning

confidence: 99%

Effects of Chloral Hydrate and its Combination with Thiopental Sodium in Buffalo Calves

Mirakhur

Singh

Sharma

et al. 1980

Zentralblatt für Veterinärmedizin Reihe A

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Summary Studies were conducted on 12 healthy buffalo calves (64–168 kg.) to evaluate the effects of chloral hydrate alone (102 mg./kg.) and chloral hydrate‐thiopental sodium anaesthesia on haemodynamics, acid base status and blood gases. Chloral hydrate alone caused a significant tachycardia, moderate transient hypotension and a significant fall in central venous pressure. There was moderate reduction in arterial pO2 and evidence of uneven ventilation of the lungs. Acid base alterations were not appreciable. Increase in blood glucose was non‐significant. The combination of chloral hydrate with thiopental sodium moderated the extent of the fall in blood pressure and central venous pressure due to thiopental sodium alone. The mild metabolic acidosis was associated with moderate respiratory acidosis. There was significant desaturation of haemoglobin with evidence of alveolar hypoventilation during the early stages of anaesthesia. The oxygen extraction ratio decreased markedly at one or other stage of anaesthesia in individual animals. The correlation of the results of these experiments with the clinical use of this combination revealed the possibility of improved tissue oxygenation by the prior use of hydrocortisones. Zusammenfassung Wirkungen von Chloralhydrat allein und in Kombination mit Thiopental‐Natrium bei Büffelkälbern Bei 12 gesunden Büffelkälbern (64–168 kg) wurden die Wirkungen der Chloralhydrat‐ (102 mg/kg) sowie der kombinierten Chloralhydrat‐Thiopental‐Natrium‐Narkose auf die Hämodynamik, den Säure‐Basen‐Haushalt und die Blutgase untersucht. Ergebnisse der reinen Chloralhydrat‐Narkose: Tachykardie; mäßige, vorübergehende Blutdrucksenkung; signifikante Abnahme des zentralen Venendruckes; mäßige Abnahme des arteriellen pO2; unregelmäßige Lungenventilation; keine nennenswerten Änderungen des Säure‐Basenstatus; keine signifikante Erhöhung der Blutglukose. Ergebnisse der kombinierten Chloralhydrat‐Thiopental‐Narkose: Geringere Senkung des Blutdruckes und des zentralen Venendruckes gegenüber der reinen Chloralhydratnarkose; mäßige metabolische Azidose und geringe respiratorische Azidose, signifikante O2‐Untersättigung des Hämoglobins wegen alveolärer Hypoventilation in der Initialphase der Narkose; zeitweise Abnahme der O2‐Utilisation bei gewissen Tieren; Verbesserung der O2‐Versorgung der Gewebe durch Hydrocortison‐Prämedikation. Résumé Action du chloralhydrate seul et en combinaison avec du thiopental‐sodium chez des veaux de buffle On a examiné les effets d'une narcose au chloralhydrate (102 mg/kg) et combinée chloralhydrate‐thiopental‐sodium sur l'hémodynamique, l'équilibre acido‐basique et les gaz sanguins chez 12 veaux de buffles sains (64–168 kg). Résultats de la narcose au chloralhydrate uniquement: tachycardie; abaissement mesuré et passager de la pression sanguine; diminution significative de la pression veineuse centrale; diminution mesurée du pO2 artériel; ventilation pulmonaire irrégulière; pas de modifications marquées du status acido‐basique; aucune élévation significative du glucose sanguin. ...

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Evaluation of Glyceryl Guaiacolate as a Muscle Relaxant in Buffalo Calves

Cited by 7 publications

References 3 publications

Anesthetic effects of ketamine-guaifenesin and isoflurane anesthesia for diaphragmatic herniorrhaphy in buffaloes

Anesthetic effects of ketamine-guaifenesin and isoflurane anesthesia for diaphragmatic herniorrhaphy in buffaloes

Oxygen Unloading Potential in Bovines in Health and Stress

Effects of Chloral Hydrate and its Combination with Thiopental Sodium in Buffalo Calves

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