Evaluation of Glycogen Phosphorylase BB (GPBB) Level in Serum as Marker in Diagnosis of Acute Ischemic Stroke

Abstract

Objective: We aimed to investigate whether Serum levels of glycogen phosphorylase BB (GPBB) isoform could be used as a potential diagnostic biomarker in Acute Ischemic Stroke (AIS) patients or not.Materials and methods : glycogen phosphorylase BB were prospectively evaluated in 40 patients aged between 40 to 70 y who were admitted within 24 h of the onset of AIS. The control group included 40 healthy volunteers of similar age without any disease.Results: There is a significant elevation in the level of GPBB in ischemic stroke group and compared with control group. For Control, the observations of GPBB had an Min = 4.91 For Stroke, the observations of GPBB had an Min = 15.32 There was a significant positive correlation between stoke and Glycogen phosphorylase (rpb = 0.7473, p< .001). The correlation coefficient between Stroke and Glycogen phosphorylase was 0.7473 indicating a large effect size. This indicates that moving from the Not having to having Stroke is associated with an increase in Glycogen phosphorylase. Therefore, Stroke tends to be associated with higher values of Glycogen phosphorylase Conclusions: 1-This study shows there is significant elevation in enzyme level of glycogen phosphorylase BB (GPBB) in ischemic stroke group and compared with control group.