The study focuses on flood susceptibility in the Nam Ngum River Basin, Lao PDR, an area prone to annual flooding due to monsoons and rainstorms. Flooding in this region significantly threatens human life, causes economic losses, and damages communities and agriculture. The study employs advanced remote sensing and machine learning techniques, including random forest (RF), support vector machine (SVM), and artificial neural networks (ANN), to address these issues and create detailed flood susceptibility maps. The machine learning models used historical flood data, Sentinel-1 SAR imagery from 2018 to 2020, and open-source flood data for training and validation. Eleven flood factors were considered. With 776 samples, 70% were trained, and 30% tested the model. Flood susceptibility map accuracy is assessed using statistical techniques such as multicollinearity, Kappa index, and area under the curve of receiver operating characteristics (AUROC). The generated flood susceptibility map is used to analyze the possible effect on the different land use/land cover classes and populations. RF outperforms SVM and ANN, achieving higher accuracy based on Receiver Operating Characteristics. The resulting flood susceptibility map reveals that 25-44% of the basin area is highly susceptible, predominantly in low-elevation and low-slope regions. Likewise, 85 to 90% of the people are highly vulnerable to flooding within 260 to 280 km 2 of built-up area. The study proposes a new approach to using machine learning and readily available remote sensing data for flood susceptibility mapping. The findings of this study provide essential insights for policymakers, aiding in disaster risk reduction and facilitating sustainable development planning in Lao PDR.