This study of the gneiss-fractured-rock aquifer in Yaoundé capital of Cameroon determines: the aquifer setting-flow systems, the aquifer type, seasonal variations in rock-water interactions, evolution of the hydrogeochemical processes, physicochemical parameters and the suitability for domestic-agro-industrial use of the groundwater. Physicochemical field tests were carried out on 445 wells during four seasons for EC, pH, TDS, Temperature and static water level from July 2016 to May 2017. 90 well samples were analyzed 45 samples per season: wet/dry. 38 borewell logs were used together with structural data to determine the aquifer setting. The field physico-chemical and laboratory analysis data of well samples were mounted unto various GIS software platforms: Global mapper, AqQa, Aquachem, Rockworks, Logplot7, Surfer and ArcGIS, to get indices/parameters/figures, by use of Durov's, Piper's and Gibbs diagrams, Water quality index WQI, USSL ratio, Sodium Absorption ratio SAR, Percent sodium %Na, Kelly Ratio KR, Magnesium Absorption Ratio MAR, Total Hardness TH, Residual Sodium Carbonate RSC and Permeability Index PI that were determined. The process of groundwater ions acquisition is threefold: by recharge through atmospheric precipitation, by ion exchange/simple dissolution between the rock-groundwater and by groundwater mixing in its flow path. Water types are Ca-HCO 3 , Mg-HCO 3 and Mg-Cl while hydrogeochemical facies are Ca-Mg-HCO 3 and Ca-Mg-Cl-SO 4. Most water samples are fresh, potable and soft all seasons. The hydrogeologi