Evaluation of growth status using endocrine growth indices, insulin-like growth factor (IGF)-I and IGF-binding protein-1b, in out-migrating juvenile chum salmon

Kaneko, Nobuto; Torao, Mitsuru; Koshino, Yousuke; Fujiwara, M.; Miyakoshi, Yasuyuki; Shimizu, Munetaka

doi:10.1016/j.ygcen.2019.01.001

Cited by 14 publications

(2 citation statements)

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“…In several fishes, including salmonids, endocrine IGF-I is valuable as a growth index because its circulating level generally correlates with individual growth rate (Beckman et al 2004a, b;Picha et al 2008;Beckman 2011). The validity of serum IGF-I as a growth index has been confirmed for juvenile chum salmon, and the juvenile growth status in the coastal area of the Abashiri region, eastern Hokkaido, has been evaluated (Kaneko et al 2015(Kaneko et al , 2019Taniyama et al 2016).…”

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confidence: 99%

Effects of fasting and water temperatures during transition from freshwater to seawater on juvenile chum salmon growth and metabolism

et al. 2021

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We examined the combined effects of fasting in freshwater and water temperature during the transition from freshwater to seawater on growth/metabolic parameters in juvenile chum salmon Oncorhynchus keta. Juveniles of 1 g in freshwater were first subjected to a 5-day fasting period at 10 or 5 °C, acclimated to either 10 or 5 °C seawater and fed ad libitum for 30 days. Control fish were transferred from 10 °C freshwater to 10 °C seawater and fed ad libitum throughout the experimental period. Serum insulin-like growth factor (IGF)-I was measured to evaluate growth status/potential and liver glycogen as an index of energy storage. Fasting in freshwater for 5 days negatively affected body size. Growth of juveniles kept at colder temperatures was retarded in seawater for at least 20 days, which may partly be explained by a lower feeding rate in cold seawater. Serum IGF-I levels were lower in fasted fish in freshwater at both temperatures and colder seawater had a negative effect on restoring serum IGF-I levels after refeeding for 20 days. Liver glycogen content was low in fish fasted in freshwater for 5 days. After refeeding in seawater for 10 days, liver glycogen content increased significantly in juveniles kept at colder temperatures. Colder water temperatures in both salinities positively affected glycogen content for 30 days after transfer to seawater, suggesting that juveniles allocated energy stores to the liver rather than growth under suboptimal feeding and temperature conditions. The findings of the present study suggested that relatively cold freshwater could negatively affect juvenile chum salmon growth soon after sea entry.

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Section: Introductionmentioning

confidence: 99%

Effects of fasting and water temperatures during transition from freshwater to seawater on juvenile chum salmon growth and metabolism

et al. 2021

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“…We have previously developed a radioimmunoassay (RIA) and a time-resolved fluoroimmunoassay (TR-FIA) for salmon IGFBP-1b and showed that circulating IGFBP-1b increased in fasting fish and negatively correlated with individual growth rates in immature coho salmon (Onocorhynchus kisutch), masu salmon (O. masou), and chum salmon (O. keta) (18,29,30,44,45). These findings led us to propose its utility as a quantitative negative index of growth.…”

Section: Introductionmentioning

confidence: 99%

Intact rather than total circulating insulin-like growth factor binding protein-1a is a negative indicator of growth in masu salmon

Kaneko

Nilsen

Tanaka

et al. 2020

American Journal of Physiology-Regulatory, Integrative and Comp

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Insulin-like growth factor binding protein (IGFBP)-1a is one of three major circulating forms in salmon and induced under catabolic conditions. However, there is currently no immunoassay available for this form because of a lack of standard and specific antibodies. We developed a time-resolved fluoroimmunoassay (TR-FIA) for salmon IGFBP-1a using recombinant protein for labeling, an assay standard, and production of antiserum. The TR-FIA had a low cross-reactivity (3.6%) with IGFBP-1b, another major form in the circulation. Fasting for 4 wk had no effect on serum immunoreactive (total) IGFBP-1a levels in yearling masu salmon, whereas 6-wk fasting significantly increased it. There was a significant, but weak, negative relationship between serum total IGFBP-1a level and individual growth rate ( r2 = 0.12, P = 0.01). We next developed a ligand immuno-functional assay (LIFA) using europium-labeled IGF-I to quantify intact IGFBP-1a. In contrast to total IGFBP-1a, serum intact IGFBP-1a levels increased after 4 wk of fasting, and refeeding for 2 wk restored it to levels similar to those of the fed control. Serum intact IGFBP-1a levels showed a significant negative correlation with individual growth rate ( r2 = 0.52, P < 0.001), which was as good as that of IGFBP-1b. Our findings using newly developed TR-FIA and LIFA suggest that regulation of intact IGFBP-1a levels has an important effect on growth in salmon and that intact IGFBP-1a is a negative index of salmon growth.

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Utilization of an endocrine growth index, insulin-like growth factor binding protein (IGFBP)-1b, for postsmolt coho salmon in the Strait of Georgia, British Columbia, Canada

Kaneko

Journey

Neville

et al. 2019

Fish Physiol Biochem

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Monitoring the growth of salmon during their early marine phase provides insights into 25 prey availability and growth rates may be linked to risks of size-dependent mortality. 26 However, the measurement of growth rate is challenging for free-living salmon in the 27 ocean. Insulin-like growth factor (IGF)-I is a growth-promoting hormone that is 28 emerging as a useful index of growth in salmon. In addition, laboratory-based studies using coho salmon have shown that one of circulating IGF-binding proteins (IGFBPs), 30 IGFBP-1b, was induced by fasting and thus could be used as an inverse index of growth 31 and/or catabolic state in salmon. However, no study has measured plasma levels of 32 IGFBP-1b in salmon in wild. We measured plasma IGFBP-1b levels for postsmolt coho 33 salmon collected in the Strait of Georgia and surrounding waters, British Columbia, 34 Canada, and compared regional differences in IGFBP-1b to ecological information such 35 as seawater temperature and stomach fullness. Plasma IGFBP-1b levels were the highest 36 in fish from Eastern Johnstone Strait and relatively high in Queen Charlotte Strait and 37 Western Johnstone Strait, which was in good agreement with the poor ocean conditions 38 for salmon hypothesized to occur in that region. The molar ratio of plasma IGF-I to 39 IGFBP-1b, a theoretical parameter of IGF-I availability to the receptor, discriminated 40 differences among regions better than IGF-I or IGFBP-1b alone. Our data suggest that 41 plasma IGFBP-1b reflects catabolic status in postsmolt coho salmon, as highlighted in 42 fish in Eastern Johnston Strait and is a useful tool to monitor negative aspects of salmon 43 growth in the ocean. 44 45 Keywords 46 65 1999). Component proteins of the endocrine growth system are attractive targets for the 66 development of biological growth markers because the proteins are not merely correlated 67 with growth but also induce growth. As such, a number of clinical assays in human 68 medicine utilize endocrine markers of growth (Klauwer et al. 1997; Balic et al. 2008; 69 Carter et al. 2014; Knacke et al. 2016). Insulin-like growth factor (IGF)-I is a peptide 70 hormone that circulates in the blood and is an integral component of the endocrine growth et al. 2006, 2009). The increased IGFBP-1b levels are presumably inhibiting IGF-I action 89 by blocking coupling of IGF-I to the IGF receptor and thus limiting growth (Kajimura 90 and Duan 2007; Wheatcroft and Kearney 2009). 91 We have previously measured salmon IGFBP-1b and revealed that it had an 92 inverse relationship with individual growth rate in salmon (Shimizu et al. 2006; 93 Kawaguchi et al. 2013; Kaneko et al. 2019). Thus, plasma IGFBP-1b may also be useful 94 as an index of growth based on this inverse relationship between IGFBP-1b and growth 95 6 under laboratory conditions. However, the utility of IGFBP-1b as a growth index in the 96 field has been reported only in one study for juvenile chum salmon (Oncorhynchus keta) 97 out-migrating from the northeast coast of Hokkaido Island, Japan (Kan...

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Evaluation of growth status using endocrine growth indices, insulin-like growth factor (IGF)-I and IGF-binding protein-1b, in out-migrating juvenile chum salmon

Cited by 14 publications

References 40 publications

Effects of fasting and water temperatures during transition from freshwater to seawater on juvenile chum salmon growth and metabolism

Effects of fasting and water temperatures during transition from freshwater to seawater on juvenile chum salmon growth and metabolism

Intact rather than total circulating insulin-like growth factor binding protein-1a is a negative indicator of growth in masu salmon

Utilization of an endocrine growth index, insulin-like growth factor binding protein (IGFBP)-1b, for postsmolt coho salmon in the Strait of Georgia, British Columbia, Canada

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