Evaluation of haemato-biochemical and oxidative indices in naturally infected concomitant tick borne intracellular diseases in dogs

Sarma, Kalyan; Mondal, Deba Brata; Saravanan, Muthupandian; Mahendran, K.

doi:10.1016/s2222-1808(14)60627-7

Cited by 5 publications

(5 citation statements)

References 33 publications

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“…Hyperechogenicity of the liver was also observed in the present study, which has been previously reported in chronic CME infections [36]. Sarma et al [18] also reported hyperechogenicity of the liver, gallbladder distention, and hepatosplenomegaly concomitant with tick-borne disease. Splenomegaly was also observed in our study, which is consistent with the findings reported by Sarma et al [34].…”

Section: E Canis=ehrlichia Canissupporting

confidence: 89%

“…The major hematological changes are interstitial nephritis and glomerulonephritis [16], whereas pathological changes occur in the corticomedullary junction, causing a contracted kidney [17]. Hyperechogenicity may be present with an enlarged liver, spleen, gallbladder, and ascites [18]. Some dogs may recover after the subclinical phase, whereas others may progress to the chronic phase where severe pancytopenia typically occurs from bone marrow hypoplasia and leads to severe leukopenia, anemia, and thrombocytopenia with a high risk of mortality [15].…”

Section: Introductionmentioning

confidence: 99%

“…These lasting effects may be missed by veterinarians that do not provide systematic follow-up after doxycycline treatment. Sarma et al [18] studied pathological changes in the liver and spleen of 101 dogs positive for infection with tick-borne blood parasites and found that ultrasound and hematological changes can serve as a useful indicator of the damage status of internal organs after infestation with blood parasites.…”

Section: Introductionmentioning

confidence: 99%

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Retrospective analysis of canine monocytic ehrlichiosis in Thailand with emphasis on hematological and ultrasonographic changes

et al. 2022

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Background and Aim: Canine monocytic ehrlichiosis (CME) is a tropical endemic tick-borne disease that causes fatality or chronic infection involving many organs in dogs. This study aimed to examine the prevalence, risk factors, and hematological and ultrasonographic changes in the liver, gallbladder, kidneys, and spleen following CME infection. Materials and Methods: This retrospective study used 30,269 samples collected from dogs at the hematology section of the pathology unit of a university veterinary hospital and 35 samples collected from dogs at the diagnostic imaging unit. CME was determined using the buffy coat smear method. Data were analyzed using descriptive statistics and odds ratios. Results: CCl4 The data revealed that the average yearly prevalence of CME was 1.32%. Risk factors contributing to CME infection were a tick on the body during physical examination, lack of ectoparasite control, and outdoor living. All 148 dogs with CME infection had low platelet counts. The percentages of CME-infected dogs with elevated serum alanine aminotransferase, alkaline phosphatase, and both enzymes above the normal range were 33.6%, 65.9%, and 29.8%, respectively. The rates for elevated serum levels of blood urea nitrogen, creatinine, and both compounds were 33.1%, 19.1%, and 17.3%, respectively. The most common ultrasonographic changes were liver abnormalities (hyperechogenicity or hypoechogenicity, hepatomegaly, and hypoechoic nodules), hyperechogenicity of the kidneys, and an enlarged spleen. These ultrasonographic changes were consistent with the hematology results, which showed a greater elevation of serum liver enzyme levels than renal enzymes. Conclusion: Ultrasonographic changes during CME infection and after treatment with doxycycline can help to monitor and identify persistent pathological changes in the target organs resulting from immune response to CME.

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Section: E Canis=ehrlichia Canissupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Retrospective analysis of canine monocytic ehrlichiosis in Thailand with emphasis on hematological and ultrasonographic changes

et al. 2022

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“…Oxidative stress and increased lipid peroxidation has been shown in dogs with CME because of free-radical activity and an impaired antioxidant system (2,8,36). Paraoxonase (PON-1) and arylesterase (ARE) are esterase enzymes with antioxidant properties in a complementary structure.…”

Section: Praca Oryginalnamentioning

confidence: 99%

Oxidative status and lipid profile in mono- and co-infection with canine monocytic ehrlichiosis

Gültekin

Ural

Paşa

et al. 2017

Medycyna Weterynaryjna

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SummaryVector-borne diseases in dogs are a major health problem of zoonotic importance. Canine monocytic ehrlichiosis (CME) is one of the most common vector-borne infections in dogs. Co-infections with vectorborne diseases are reported to cause more severe pathological effects than mono-infections. The current study investigates the effects of mono-and co-infections with CME on oxidative status and lipid profiles in dogs. Dogs with vector-borne diseases were divided into two groups, mono-infected (n = 22) and co-infected (n = 23) with CME, and compared to a healthy group (n = 20). Double and triple co-infections with other vector-borne diseases included A. phagocytophilum, L. infantum, and D. immitis. The serum lipid profile (high-density lipoprotein (HDL), low-density lipoprotein (LDL), cholesterol, and triglycerides) and the total and individual markers of oxidative status (total antioxidant capacity (TAC), total oxidant status (TOS), malondialdehyde (MDA), paraoxonase (PON-1), and arylesterase (ARE)) were evaluated. Significant decreases in PON-1 and ARE enzyme activities and HDL concentration, as well as increases in TOS level, MDA, LDL, and triglyceride concentrations were determined in both mono-and co-infected groups compared to the healthy control group. No significant differences between the groups were found in the TAC level or cholesterol concentration. In conclusion, alterations in lipid profile and increase in oxidative stress were observed in dogs with CME compared to the healthy control group, however, no significant differences were detected between mono-and co-infected dogs.

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“…There would be significant changes in the hematology and biochemistry of the hosts suffering from parasitic infestation, depending on the parasite species and the affected body sites (14). These hematological and biochemical alterations can be useful in assessment of infestation severity, animal physiological status, and management practice planning (15). To our best knowledge, there is not a sufficient literature on hematological and oxidative stress values on infested animals by parasites, especially tick-related infestations.…”

Section: Introductionmentioning

confidence: 99%

Hematological and Oxidative Status Parameters in Domestic Dogs Naturally Infested by Rhipicephalus Sp.

Kebbi

Besseboua

Belhadj-Kebbi

et al. 2020

Macedonian Veterinary Review

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The present study was aimed to evaluate hematological and oxidative stress parameters in domestic dogs infested naturally (n=10) by Rhipicephalus sp. to compare with non-infested dogs (n=10). All blood samples were collected from brachial vein into tubes EDTA for the hematological analysis such as red blood cells (RBCs), white blood cells (WBCs), hemoglobin (HGB) and platelets (PLT). Serum was rapidly separated after centrifugation and stored at -20 °C until it was used for malondialdehyde (MDA) and 2,2’-Azinobis-(3-ethylbenzothiazoline)-6-sulfonic acid (ABTS) inhibition measurements. HGB in non-infested dogs was significantly higher than in infested dogs (P<0.05). There was no significant difference in RBCs, WBCs and PLT between both groups (P>0.05). The mean of MDA concentration was high in infested dogs (0.92±0.62 nmol/ml) compared to non-infested dogs (0.75±0.25 nmol/ml). On the other hand, the percentage of ABTS inhibition was similar in both groups (P=0.71). High tick number seems significantly affected WBCs (P<0.0001) and HGB (P<0.001) in infested dogs. Concerning oxidative status, there was no significant differences (P>0.05) between low and high infested dogs, neither in the amount of MDA nor in the ABTS inhibition. In conclusion, infested dogs induced RBCs alterations, which coincided with the oxidative damage, as evidenced by MDA serum levels. Also, there was a relationship between the tick number in infested dogs and the hematological parameters.

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Evaluation of haemato-biochemical and oxidative indices in naturally infected concomitant tick borne intracellular diseases in dogs

Cited by 5 publications

References 33 publications

Retrospective analysis of canine monocytic ehrlichiosis in Thailand with emphasis on hematological and ultrasonographic changes

Retrospective analysis of canine monocytic ehrlichiosis in Thailand with emphasis on hematological and ultrasonographic changes

Oxidative status and lipid profile in mono- and co-infection with canine monocytic ehrlichiosis

Hematological and Oxidative Status Parameters in Domestic Dogs Naturally Infested by Rhipicephalus Sp.

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