Evaluation of haematological, hepatic and renal functions of petroleum tanker drivers in Lagos, Nigeria

Awodele, Olufunsho; Sulayman, Ademola A; Akintonwa, A

doi:10.4314/ahs.v14i1.27

Cited by 13 publications

(10 citation statements)

References 10 publications

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“…Studies among healthy workers exposed to hydrocarbons have shown a higher incidence of proteinuria, oliguria, albuminuria, hematuria, and leucocyturia than controls [50,[106][107][108][109]. Furthermore, an increased incidence of raised blood pressure (BP) [103] and anaemia [6] has also been reported.…”

Section: Nephrotoxicitymentioning

confidence: 99%

“…Several mechanisms contribute to gasolineinduced hepatotoxicity, including the induction of cellular degeneration, downregulation of gene expression, and induction of oxidative stress [132]. Inhibition of CYP2E1, which was recently reported in animals exposed to gasoline vapors [103] is potentially deleterious to the liver. However, induction of oxidative stress appears to play a central role in the initiation and progression of gasolineinduced hepatotoxicity.…”

Section: Hepatotoxicitymentioning

confidence: 99%

“…Many human and animal studies [103,[125][126][127][128][129][130] A -gasoline (parent nephrotoxicant) may bind to the membrane lipid bilayer and proteins due to its high lipophilicity, leading to damage to the membrane bilayer and proteins, which causes inhibition of Na + /K + /ATPase activity, which in turn leads to disruption of ion homeostasis and cell injury; B -alternatively, gasoline may undergo biotransformation to reactive intermediates (e.g., 1,2,3-benzenetriol and benzequinone) that bind covalently to macromolecules and in turn alter their activity (e.g., inhibition of Na + /K + /ATPase), resulting in cell injury; C -additionally, gasoline may increase in the renal cells directly after being biotransformed into reactive intermediates through redox cycling. The resultant increase in ROS may cause oxidative damage and cell injury; D -finally, the generated ROS may cause disruption of the immune system, leading to immune perturbation, and a resultant induction of autoimmunity.…”

Section: Hepatotoxicitymentioning

confidence: 99%

“…, and bicarbonate (HCO 3 -)) balance [98][99][100][101][102][103]. Impaired excretion of metabolic waste products, e.g., creatinine, urea, blood urea nitrogen (BUN), and uric acid [94,104,105], and altered acid-base homeostasis [102].…”

Section: Nephrotoxicitymentioning

confidence: 99%

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Recent advances in occupational and environmental health hazards of workers exposed to gasoline compounds

Ekpenyong

Asuquo

2017

Int J Occup Med Environ Health

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The impact of health and environmental hazards, associated with the constituents of gasoline, on occupationally exposed workers has been recorded over the past few decades. However, the scientific literature on their pathogenic potential remains incomplete, which could affect the current understanding of the associated health risks. This review provides current information based on recently improved research techniques to evaluate gasoline toxicity profiles for humans. Our current knowledge provides insight into the intricate mechanism of gasoline-induced adverse effects, including the formation of reactive metabolites via bio-activation and subsequent generation of reactive oxygen species (ROS) and oxidative stress, which are involved in multiple mechanisms that are central to the aetiology of gasoline-induced toxicity. These mechanisms include covalent binding to deoxyribonucleic acid (DNA), leading to oxidative damage, tumor-suppression gene activity, and activation of pro-oncogenes. Furthermore, it results in induction of autoimmunity and local inflammatory responses, disruption of multiple neurotransmitters and immune cell function, derangement of various enzyme activities (e.g., sodiumpotassium adenosine triphosphate (Na + /K + /ATPase) activity, cytochrome P450 (CYP450), nitric oxide synthase (NOS), antioxidant enzyme activities, etc.), conjugation of bile, and non-specific cell membrane interaction, leading to damage of the membrane lipid bilayer and proteins. Available data suggests that exposure to gasoline or gasoline constituents have the potential to cause different types of illnesses. The data highlights the need to maintain safety measures via suitable research, medical surveillance, regulatory control, life style modification, early detection, and intervention to minimize exposure and manage suspected cases. They also present novel opportunities to design and develop effective therapeutic strategies against gasoline-induced detrimental effects. Int J Occup Med Environ Health 2017;30(1):1-26

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Section: Nephrotoxicitymentioning

confidence: 99%

Section: Hepatotoxicitymentioning

confidence: 99%

Section: Hepatotoxicitymentioning

confidence: 99%

Section: Nephrotoxicitymentioning

confidence: 99%

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Recent advances in occupational and environmental health hazards of workers exposed to gasoline compounds

Ekpenyong

Asuquo

2017

Int J Occup Med Environ Health

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“…The antibacterial activities of developed PVA silver nanocomposite films against Staphylococcus aureus , Vibrio cholera , Gram positive Bacilli , E. coli , and Pseudomonas aerugenosa as model bacteria were determined by zone of inhibition method as described by WHO (2003). Nutrient agar plates (5 g peptone, 5 g NaCl, 3 g Beef extract, and Agar 2% in 1000 mL) were prepared and seeded with 200 µL of test bacteria.…”

Section: Methodsmentioning

confidence: 99%

Preparation and characterization of poly(vinyl alcohol) cryogel-silver nanocomposites and evaluation of blood compatibility, cytotoxicity, and antimicrobial behaviors

Chaturvedi

Bajpai

2014

Polym. Compos.

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In this investigation, cryogels composed of poly(vinyl alcohol) (PVA) were prepared by repeated freeze‐thaw method. The prepared cryogels served as templates for producing highly stable and uniformly distributed silver nanoparticles via in situ reduction of silver nitrate (AgNO3) using alkaline formaldehyde solution as reducing agent. The structure of the PVA/Ag cryogel nanocomposites was characterized by a Fourier transform infrared and Raman spectroscopy. The morphologies of pure PVA cryogels and PVA/Ag nanocomposites were observed by a scanning electron microscopy (SEM) and transmission electron microscopy (TEM) techniques. The SEM analysis suggested that cryogels show a well defined porous morphology whereas TEM micrographs revealed the presence of nearly spherical and well separated Ag nanoparticles with diameter about 100 nm. XRD results showed all relevant Bragg's reflections for crystal structure of silver nanoparticles. The amount of silver in cryogel nanocomposites and thermal stability were determined by inductively coupled plasma atomic emission spectrometry (ICP‐AES) and thermogravimetric analysis measurements. Mechanical properties of nanocomposites were observed in terms of tensile strength. The antibacterial studies of the synthesized nanosilver containing cryogels showed good antibacterial activity against both gram‐negative and gram‐positive bacteria. The prepared PVA/Ag nanocomposites were also investigated for swelling and deswelling behaviors. The results reveal that both the swelling and deswelling process depends on the chemical composition of the cryogel silver nanocomposites, number of freeze‐Thaw cycles and pH and temperature of the swelling medium. The biocompatibility of the prepared nanocomposites was judged by in vitro methods of percent hemolysis and protein (BSA) adsorption. POLYM. COMPOS., 36:1983–1997, 2015. © 2014 Society of Plastics Engineer

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Experimental exposure to gasohol impairs sperm quality with recognition of the classification pattern of exposure groups by machine learning algorithms

Vieira

Fernandes

Silva

et al. 2018

Environ Sci Pollut Res

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Evaluation of haematological, hepatic and renal functions of petroleum tanker drivers in Lagos, Nigeria

Cited by 13 publications

References 10 publications

Recent advances in occupational and environmental health hazards of workers exposed to gasoline compounds

Recent advances in occupational and environmental health hazards of workers exposed to gasoline compounds

Preparation and characterization of poly(vinyl alcohol) cryogel-silver nanocomposites and evaluation of blood compatibility, cytotoxicity, and antimicrobial behaviors

Experimental exposure to gasohol impairs sperm quality with recognition of the classification pattern of exposure groups by machine learning algorithms

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