Evaluation of halobetasol propionate ointment in the treatment of plaque psoriasis: Report on two double-blind, vehicle-controlled studies

Bernhard, Jeffrey D.; Whitmore, Claire; Guzzo, Cynthia; Kantor, Irwin; Kalb, Robert E.; Ellis, Charles N.; Urbach, Frederick; Schwartzel, Edmund H.; Gibson, John R.

doi:10.1016/0190-9622(91)70320-2

Cited by 30 publications

(25 citation statements)

References 2 publications

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“…[8283] Treatment is generally twice a day for approximately 2 weeks followed by an intermittent dosing regimen to preserve remission. Similarly, midpotent TCS such as fluticasone propionate has also been found to be effective in plaque psoriasis.…”

Section: Topical Corticosteroidsmentioning

confidence: 99%

Topical therapies in psoriasis

Torsekar

Gautam

2017

Indian Dermatol Online J

106

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Topical therapy as monotherapy is useful in psoriasis patients with mild disease. Topical agents are also used as adjuvant for moderate-to-severe disease who are being concurrently treated with either ultraviolet light or systemic medications. Emollients are useful adjuncts to the treatment of psoriasis. Use of older topical agents such as anthralin and coal tar has declined over the years. However, they are cheaper and can still be used for the treatment of difficult psoriasis refractory to conventional treatment. Salicylic acid can be used in combination with other topical therapies such as topical corticosteroids (TCS) and calcineurin inhibitors for the treatment of thick limited plaques to increase the absorption of the latter into the psoriatic plaques. Low- to mid-potent TCS are used in facial/flexural psoriasis and high potent over palmoplantar/thick psoriasis lesions. The addition of noncorticosteroid treatment can also facilitate the avoidance of long-term daily TCS. Tacrolimus and pimecrolimus can be used for the treatment of facial and intertriginous psoriasis. Tazarotene is indicated for stable plaque psoriasis usually in combination with other therapies such as TCS. Vitamin D analogs alone in combination with TCS are useful in stable plaques over limbs and palmoplantar psoriasis. Topical therapies for scalp psoriasis include TCS, Vitamin D analogs, salicylic acid, coal tar, and anthralin in various formulations such as solutions, foams, and shampoos. TCS, vitamin D analogs, and tazarotene can be used in the treatment of nail psoriasis.

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Section: Topical Corticosteroidsmentioning

confidence: 99%

Topical therapies in psoriasis

Torsekar

Gautam

2017

Indian Dermatol Online J

106

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“…We retrieved details of 52 randomized controlled trials comparing active treatments against placebo 6–57 . In all instances the placebo consisted of the emollient vehicle used by the active treatment or some similar emollient.…”

Section: Resultsmentioning

confidence: 99%

Topical preparations for the treatment of psoriasis: a systematic review

2002

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“…The effi cacy rates of ultrapotent corticosteroids range from moderate or better improvement of PGA in 58% of patients, to overall improvement of PGA in 92% of patients, while with mild corticosteroids, PGA improvement has been reported as excellent or good in 41% of patients and as good or better in 83% of treated patients [25][26][27][28] .…”

Section: Corticosteroidsmentioning

confidence: 99%