Evaluation of hearing and auditory nerve function by combining ABR, DPOAE and eABR tests into a single recording session

Polák, Marek; Eshraghi, Adrien A.; Nehme, Omar; Ahsan, Syed F.; Guzmán, José Eduardo; Delgado, Rafael E.; He, Jianbin; Telischi, Fred F.; Bałkany, Thomas J.; Water, Thomas R. Van De

doi:10.1016/j.jneumeth.2003.11.003

Cited by 41 publications

(22 citation statements)

References 31 publications

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“…Recordings were made at intensity levels of 45, 55, 65 and 75 dB SPL. These settings were based both on our own trials and on previous studies (Polak 2004) to obtain the largest DPOAE responses. The DPOAE response generated at 2F1-F2 was used in analyses by plotting the amplitude of the response against the F1/F2 stimulus frequency.…”

Section: Otoacoustic Emission Recordingsmentioning

confidence: 99%

Brain-Derived Neurotrophic Factor Modulates Auditory Function in the Hearing Cochlea

Sly

Hampson

Minter

et al. 2011

JARO

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Neurotrophins prevent spiral ganglion neuron (SGN) degeneration in animal models of ototoxin-induced deafness and may be used in the future to improve the hearing of cochlear implant patients. It is increasingly common for patients with residual hearing to undergo cochlear implantation. However, the effect of neurotrophin treatment on acoustic hearing is not known. In this study, brain-derived neurotrophic factor (BDNF) was applied to the round window membrane of adult guinea pigs for 4 weeks using a cannula attached to a mini-osmotic pump. SGN survival was first assessed in ototoxically deafened guinea pigs to establish that the delivery method was effective. Increased survival of SGNs was observed in the basal and middle cochlear turns of deafened guinea pigs treated with BDNF, confirming that delivery to the cochlea was successful. The effects of BDNF treatment in animals with normal hearing were then assessed using distortion product otoacoustic emissions (DPOAEs), pure tone, and clickevoked auditory brainstem responses (ABRs). DPOAE assessment indicated a mild deficit of 5 dB SPL in treated and control groups at 1 and 4 weeks after cannula placement. In contrast, ABR evaluation showed that BDNF lowered thresholds at specific frequencies (8 and 16 kHz) after 1 and 4 weeks posttreatment when compared to the control cohort receiving Ringer's solution. Longer treatment for 4 weeks not only widened the range of frequencies ameliorated from 2 to 32 kHz but also lowered the threshold by at least 28 dB SPL at frequencies ≥16 kHz. BDNF treatment for 4 weeks also increased the amplitude of the ABR response when compared to either the control cohort or prior to treatment. We show that BDNF applied to the round window reduces auditory thresholds and could potentially be used clinically to protect residual hearing following cochlear implantation.

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Section: Otoacoustic Emission Recordingsmentioning

confidence: 99%

Brain-Derived Neurotrophic Factor Modulates Auditory Function in the Hearing Cochlea

Sly

Hampson

Minter

et al. 2011

JARO

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“…Electrode coupling was monopolar with the reference electrode according to the Pulsar/Sonata stimulator. The stimulation technique was adapted from Polak et al (2004) and included the following: (1) recording electrodes were placed on the forehead (+) and mastoid (À) with the mastoid electrode on the same side as the implant; (2) the ground electrode was positioned on the central forehead; (3) stimulation with alternating polarity; (4) averaged recordings derived by equal numbers (n = 1000) of cathodic/anodic pulses were collected. Recording results were displayed with the centered line as the average, and the surrounding lines corresponding to each leading polarity (see, for example, Fig.…”

Section: Stimulation and Recording Paradigmmentioning

confidence: 99%

Recording of electrically evoked auditory brainstem responses after electrical stimulation with biphasic, triphasic and precision triphasic pulses

2010

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“…The hearing of both ears of all guinea pigs was measured by ABR responses to pure-tone stimuli (0.5Y16 kHz) at presurgery and on post-EIT on Days 0, 3, 5, 7, 14, and 30 as previously described (15). Intelligent Hearing Systems (IHS, Miami, FL, USA) hardware and software were used to record ABR responses to pure-tone stimuli of 0.5, 1, 4, and 16 kHz.…”

Section: Abr Recordingmentioning

confidence: 99%

Local Dexamethasone Therapy Conserves Hearing in an Animal Model of Electrode Insertion Trauma-Induced Hearing Loss

Eshraghi

Adil

et al. 2007

Otology &Amp; Neurotology

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122

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Evaluation of hearing and auditory nerve function by combining ABR, DPOAE and eABR tests into a single recording session

Cited by 41 publications

References 31 publications

Brain-Derived Neurotrophic Factor Modulates Auditory Function in the Hearing Cochlea

Brain-Derived Neurotrophic Factor Modulates Auditory Function in the Hearing Cochlea

Recording of electrically evoked auditory brainstem responses after electrical stimulation with biphasic, triphasic and precision triphasic pulses

Local Dexamethasone Therapy Conserves Hearing in an Animal Model of Electrode Insertion Trauma-Induced Hearing Loss

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