Evaluation of hela cell lineage response to β radiation from Holmium-166 embedded in ceramic seeds

Abstract

This work studied the effects of β radiation of

The various therapeutic applications of the medical isotope holmium-166: a narrative review

“…This technique involves the homogenization of several components, pouring into moulds and then following a specific procedure of gelation, aging, drying and heat treatment (Hench and West 1990). The preparation of seeds (Diniz et al 2017; Valente et al 2011; Nogueira and Campos 2011; Nogueira and de Campos 2012; Nogueira and Campos 2016) and membranes (Nogueira and de Campos 2012) composed of 165 Ho have been reported in the literature. Seeds usually have dimensions ranging from 0.3 to 0.8 mm in diameter and 1.5 to 1.8 mm in length and a density of 2 to 3.7 g/cm 3 (Valente et al 2011; Nogueira and Campos 2011).…”

“…The preparation of seeds (Diniz et al 2017; Valente et al 2011; Nogueira and Campos 2011; Nogueira and de Campos 2012; Nogueira and Campos 2016) and membranes (Nogueira and de Campos 2012) composed of 165 Ho have been reported in the literature. Seeds usually have dimensions ranging from 0.3 to 0.8 mm in diameter and 1.5 to 1.8 mm in length and a density of 2 to 3.7 g/cm 3 (Valente et al 2011; Nogueira and Campos 2011). Holmium concentrations of 20 wt% (Valente et al 2011) up to 30 wt% (Nogueira and Campos 2016) are achieved in these materials and it has been shown that the radionuclides are homogeneously distributed in the seeds matrix (Nogueira and Campos 2011).…”

“…Seeds usually have dimensions ranging from 0.3 to 0.8 mm in diameter and 1.5 to 1.8 mm in length and a density of 2 to 3.7 g/cm 3 (Valente et al 2011; Nogueira and Campos 2011). Holmium concentrations of 20 wt% (Valente et al 2011) up to 30 wt% (Nogueira and Campos 2016) are achieved in these materials and it has been shown that the radionuclides are homogeneously distributed in the seeds matrix (Nogueira and Campos 2011). Neutron activation is performed on the final material and, although different elements in the matrix can be neutron activated, it has been shown that the radionuclide impurities are negligible due to low neutron cross-section of the materials used in their fabrication (Nogueira and Campos 2011).…”

Dosimetric intercomparison of permanent Ho-166 seed's implants and HDR Ir-192 brachytherapy in breast cancer

“…15,16 In turn, permanent implants of biodegradable ceramic seeds with Si, Ca and Ho composition have been developed early. [17][18][19][20][21][22] Such seeds have the length of 1.6 mm and 0.5 mm in diameter, with a polymeric resin covering. Permanent breast implants can be produced by the insertion of a set of fine hypodermic needles distributing those small seeds on the tumor.…”

Biodegradable seeds of holmium don’t change neurological function after implant in brain of rats

“…2 Recent scientific advances in diagnosis and disease control have not yet been sufficient to provide a cure for cancer, although remission occurs in many cases. 3 Thus, the search for new treatment modalities is still required. [4][5][6] Brachytherapy is an efficient method for cancer treatment, 7 deploying discreet radioactive segments (seeds) in the tumor and generating a high local radiation dose, which is able to eliminate tumor cells while preserving the healthy surrounding tissue.…”