Evaluation of hematological indices among insecticides factory workers

Nejatifar, Fatemeh; Abdollahi, Mohammad; Attarchi, Mirsaeed; Roushan, Zahra Atrkar; Deilami, Alireza Etemadi; Joshan, Maryam; Rahattalab, Fateme; Faraji, Niloofar; Kojidi, Hamid Mohammadi

doi:10.1016/j.heliyon.2022.e09040

Cited by 8 publications

(12 citation statements)

References 31 publications

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“…In the present study, we found significant differences in hematological parameters between the different exposure groups (moderate and high pesticide exposure compared to the reference group). These results are similar to those published recently by Nejatifar et al (2022), who observed that NLR and other hematologic parameters, such as platelet count, red blood cell distribution, and the number of white blood cells, neutrophils, basophils, and eosinophils, in a group exposed to pesticides were significantly higher than in the unexposed group.…”

Section: Discussionsupporting

confidence: 92%

“…Accordingly, there is keen interest among researchers in characterizing diverse parameters of inflammation that can serve as prognostic tools in a broad array of diseases (Li et al 2018;Aydin et al 2022;Kara et al 2022). Indices based on cell counts have been used detect inflammatory events that are triggered by exposure to pesticides, and NLR is one of the most widely used indices (Dundar et al 2014;Nejatifar et al 2022). In the present study, we found significant differences in hematological parameters between the different exposure groups (moderate and high pesticide exposure compared to the reference group).…”

Section: Discussionmentioning

confidence: 99%

“…Few studies have explored the relationship between pesticide exposure and hematological indices as indicators of inflammation. In most of these studies, only NLR, PLR, MLR, and SII indices were found to be determinate in acute intoxication (Dundar et al 2014;Elhosary and Abdelbar 2018;Wang et al 2019;Nejatifar et al 2022). To the best of our knowledge, this is the first study in which eight inflammatory indices (AISI, MHR, MLR, NLPR, NLR, PLR, SII, and SIRI) are evaluated in a population chronically exposed to pesticides.…”

Section: Introductionmentioning

confidence: 98%

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Hematological indices as indicators of inflammation induced by exposure to pesticides

Ruíz-Arias

Medina-Díaz

Bernal-Hernández

et al. 2022

Environ Sci Pollut Res

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Pesticide toxicity, both acute and chronic, is a global public health concern. Pesticides are involved in abnormal inflammatory responses by interfering with the normal physiology and metabolic status of cells. In this regard, inflammatory indices aggregate index of systemic inflammation (AISI), monocyte-to-high-density lipoprotein ratio, monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte platelet ratio (NLPR), neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, systemic immune inflammation index, and systemic inflammation response index (SIRI) have been used as predictive markers of inflammatory status in several diseases and also in acute poisoning events. This study aimed to determine systemic inflammation indices and their relationship with pesticide exposure from urban sprayers in 302 individuals categorized into three groups (reference group and moderate and high exposure groups). The data suggest that the AISI, MLR, NLPR, and SIRI indices were significantly higher in the exposed groups compared with the reference group. In conclusion, this study proposes that inflammation indices warrant further attention in order to assess their value as early biomarkers of acute and chronic pesticide intoxication.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

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Hematological indices as indicators of inflammation induced by exposure to pesticides

Ruíz-Arias

Medina-Díaz

Bernal-Hernández

et al. 2022

Environ Sci Pollut Res

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“…RBC lifetime is shortened by oxidative stress. 17 These results were similar to the case report in Thailand on farmers exposed to different types of pesticides. 18 Lipid peroxidation is the first step in cellular membrane damage therefore, it is a crucial indicator of oxidative damage of cellular components caused by pesticides, metals, and other xenobiotics.…”

Section: Discussionsupporting

confidence: 87%

“…The decrease in the number of RBCs may be due to the enhancement effect of PDB on oxidative damage. RBC lifetime is shortened by oxidative stress 17 …”

Section: Discussionmentioning

confidence: 99%

Hematological, biochemical, genotoxic, and histopathological changes induced by pyridaben

Ali

Mohamed

2023

Environmental Toxicology

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The current work examined the genotoxic effects of pyridaben (PDB) in male Sprague Dawley rats. Twenty Sprague Dawley rats were divided into four equal groups; the first group was used as a control group; the other three groups were exposed to 19, 28.5, and 57 mg/kg b.w PDB by oral gavage for 4 weeks. Blood samples were collected for hematological and biochemical parameters; femoral bone marrow was flushed for chromosomal aberrations (CA) assay and liver samples were used for the analysis of gene expression of IL‐6 and Casp‐3 as well as histopathological and immunhistochemical investigation for Casp‐3. The results showed that PDB exposure lead to non‐significant changes in hematological parameters in all PDB administrated groups while malondialdehyde, glutathione peroxidase, aspartate aminotransferase, and alkaline phosphatase were significantly increased in 19 and 57 mg/kg PDB doses groups Also, gene expression of IL‐6 and Casp‐3 revealed a significant increase in 28.5 and 57 mg/kg PDB doses groups as compared with the control. However, there was no significant change in the percentage of CAs in bone marrow cells in all PDB‐exposed groups. The histopathological and immunhistochemical examination showed focal areas of inflammatory cellular infiltration with fibrosis in 57 mg/kg b.w PDB dose group accompanied by the severe positive reaction of caspase3 in the liver.

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Unveiling the link: Neonicotinoids and elevated cardiometabolic risks in Chinese rural residents–from a prospective cohort study combing mendelian randomization study

Wu,

Wei,

Guo

et al. 2024

Journal of Hazardous Materials

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Evaluation of hematological indices among insecticides factory workers

Cited by 8 publications

References 31 publications

Hematological indices as indicators of inflammation induced by exposure to pesticides

Hematological indices as indicators of inflammation induced by exposure to pesticides

Hematological, biochemical, genotoxic, and histopathological changes induced by pyridaben

Unveiling the link: Neonicotinoids and elevated cardiometabolic risks in Chinese rural residents–from a prospective cohort study combing mendelian randomization study

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