Evaluation of Hematological Parameters as a Possible Marker for Head - And - Neck Cancer and Precancerous Conditions

Bhattacharjee, Abhinandan; Borah, Florence Ratna; Giri, Shailendra; Devnath, Bapan; Uddin, Sharif

doi:10.14260/jemds/2015/2357

Cited by 2 publications

(2 citation statements)

References 28 publications

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“…Whilst several studies have reported positive associations between MCHC and oral squamous cell carcinoma [ 80 ] or head and neck cancers [ 81 ], others found no statistically significant associations [ 82 , 83 ].…”

Section: Discussionmentioning

confidence: 99%

A prospective cohort examination of haematological parameters in relation to cancer death and incidence: the Busselton Health Study

et al. 2018

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BackgroundCancer risk is associated with serum iron levels. The aim of this study was to evaluate whether haematological parameters reflect serum iron levels and may also be associated with cancer risk.MethodsWe studied 1564 men and 1769 women who were enrolled in the Busselton Health Study, Western Australia. Haematological parameters evaluated included haemoglobin (Hb), mean cell volume (MCV), mean cell haemoglobin (MCH) and mean cell haemoglobin concentration (MCHC) and red cell distribution width (RCDW). Statistical analyses included t-tests for quantitative variables, chi-square tests for categorical variables and Cox proportional hazards regression modelling for cancer incidence and death.ResultsThere was marginal evidence of an association between MCV (as a continuous variable) and non-skin cancer incidence in women (HR 1.15, 95% CI 1.013, 1.302; p = 0.030) but the hazard ratio was attenuated to non-significance after adjustment for serum ferritin (SF), iron and transferrin saturation (TS) (HR 1.11, 95% CI 0.972, 1.264; p = 0.126). There was strong evidence of an association between MCHC and prostate cancer incidence in men; the estimated hazard ratio for an increase of one SD (0.5) in MCHC was 1.27 (95% CI 1.064, 1.507; p = 0.008). These results remained significant after further adjustment for SF and iron; the estimated hazard ratio for an increase of one SD (0.5) in MCHC was 1.25 (p = 0.014, 95% CI 1.05 to 1.48).ConclusionsThe MCHC and MCV were associated with cancer incidence in a Western Australian population, although only MCHC remained associated with prostate cancer after adjusting with serum iron and TS (circulating iron) and SF (storage iron). Haematological parameters are thus of limited utility in population profiling for future cancer risk.

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Section: Discussionmentioning

confidence: 99%

A prospective cohort examination of haematological parameters in relation to cancer death and incidence: the Busselton Health Study

et al. 2018

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“…22 For other risk factors, such as p53 mutation, loss of heterozygosity (LOH), HPV, etc. 23 Claudia Cordilla in the study revealed hemoglobin status is associated with lymph node metastasis in squamous cell carcinoma of oral cavity but not with initial T stage. 24 Also, contrary to this study finding, Bhattacharjee et al showed statistically significant difference in hemoglobin value between squamous cell carcinoma of oral cavity and epithelial precursor lesion with the control.…”

Section: Discussionmentioning

confidence: 89%

Evaluation of hematological parameters in oral cancer and oral pre-cancer

Singh

Chandra

et al. 2020

Int J Basic Clin Pharmacol

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Background: Oral squamous cell carcinoma (OSCC) is the most common public health issue in Indian population. Quite a large number of OSCC cases are preceded by potentially malignant disorders of oral cavity. The need for simple diagnostic marker for early diagnosis and thus better therapeutic outcome is imperative. The current study aims to evaluate hematological parameters such as hemoglobin, bleeding time, clotting time, total leucocyte count (TLC) and differential leucocyte count (DLC) in OSCC and oral potentially malignant disorder cases along with normal healthy controls.Methods: A total of 150 subjects; 50 in each group were taken and 2.5 ml of blood were withdrawn from each subject and TLC, DLC and hemoglobin assessment was done using autoanalyzer while bleeding time and clotting time was recorded through Duke’s method and modified Dale’s method respectively.Results: All the data were tabulated and recorded as mean±standard deviation and comparison was done using one-way ANOVA test (p<0.05). TLC count, neutrophil count and lymphocyte count showed statistically significant difference amongst three groups while other parameters such as hemoglobin percentage, bleeding time, clotting time, eosinophil count, monocyte count and basophil count were statistically non-significant.Conclusions: This study showed TLC count, neutrophil count and lymphocyte count might prove as useful determinant factor in oral squamous cell carcinoma and oral potentially malignant disorders. However, further study with larger sample size is required to establish their role as diagnostic, prognostic marker or predictor of malignant transformation.

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Evaluation of Hematological Parameters as a Possible Marker for Head - And - Neck Cancer and Precancerous Conditions

Cited by 2 publications

References 28 publications

A prospective cohort examination of haematological parameters in relation to cancer death and incidence: the Busselton Health Study

A prospective cohort examination of haematological parameters in relation to cancer death and incidence: the Busselton Health Study

Evaluation of hematological parameters in oral cancer and oral pre-cancer

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