Evaluation of Hemodynamic Properties of Cerebral Venous Drainage in Patients with Multiple Sclerosis: A Case-Control Study

Jandaghi, Ali Babaei; Amanian, Dayan; Roudbari, Seyed Ali; Kanafi, Alireza Rajabzadeh; Pourghorban, Ramin

doi:10.12659/pjr.890690

Cited by 4 publications

(4 citation statements)

References 37 publications

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“…2 Among the potential factors that were related to MS, abnormal venous haemodynamics in the neck, including venous reflux and stenosis, has been hypothesized to be a feature of MS. [3][4][5][6] During the past few years, different studies were carried out to investigate the possible role of extracranial venous flow abnormalities in MS. These studies used different image modalities such as ultrasound 3,5,[7][8][9][10][11][12][13][14] and MRI, including contrast-enhanced MR venography (CE-MRV), phasecontrast MRI or time-of-flight sequences, 4,[15][16][17][18][19][20] and a combination of different imaging modalities. [21][22][23][24][25][26] These studies, however, yielded somewhat conflicting results, and the role of venous abnormalities in MS still remains in discussion.…”

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confidence: 99%

Lack of correlation between extracranial venous abnormalities and multiple sclerosis: a quantitative MRI study

Cocozza¹,

Canna²,

Lanzillo³

et al. 2016

BJR

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Sirio Cocozza and Antonietta Canna contributed equally to this work. Giuseppe Palma and Enrico Tedeschi share senior authorship.Objective: We aimed to evaluate the presence of venous stenosis and blood flow abnormalities in the neck vessels of patients with multiple sclerosis (MS), in respect to a group of age-and sex-matched healthy controls (HC), and their possible relations with clinical variables using a semi-automated quantitative MRI method. Methods: 45 patients with relapsing remitting MS and 40 HC were enrolled in this study. Flow rates and crosssectional areas of arterial and venous neck vessels were assessed by phase-contrast MRI at two different neck levels (C2-C3 and C6-C7), and differences between groups were evaluated with an unpaired t-test. Correlation between blood flow variables and clinical parameters was analyzed with Spearman's test. Results: A significant internal jugular vein (IJV) stenosis was found in 23/45 (51.1%) patients with MS and 18/40 (45.0%) HC. No differences were observed between patients with MS and HC for any of the flow measures obtained. No correlations were found between MRI measures and any of the tested clinical variables. Conclusion: No differences in the IJV area emerged at quantitative MRI evaluation, suggesting that stenosis of the extracranial veins is unrelated to MS. Furthermore, no flow differences in the neck vessels were found between patients with MS and HC in any of the tested flow measures, with no correlation with clinical variables. Our results confirm that the hypothesis of the presence of extracranial venous abnormalities in MS, both in terms of stenosis or flow measures, is not suitable. Advances in knowledge: Neck venous drainage abnormalities have been claimed to be associated with MS. Conversely, our quantitative MRI analysis seems to exclude that extracranial venous alterations are related to the disease.

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Section: Introductionmentioning

confidence: 99%

Lack of correlation between extracranial venous abnormalities and multiple sclerosis: a quantitative MRI study

Cocozza¹,

Canna²,

Lanzillo³

et al. 2016

BJR

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“…Multiple sclerosis (MS) is a progressive, chronic, demyelinating, neurodegenerative disease affecting the central nervous system (CNS). MS can cause a wide range of symptoms, including decline of cognitive abilities [ 1 , 2 ]. Cognitive impairment (CI) in MS patients substantially impacts the lives of the patients and their families [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

The BICAMS Battery for Assessment of Lithuanian-Speaking Multiple Sclerosis Patients: Relationship with Age, Education, Disease Disability, and Duration

2015

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BackgroundAssessment of cognitive impairment (CI) in multiple sclerosis (MS) patients is very useful, but it requires time-consuming expert evaluation with specialized materials. The Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) was created as a brief and specific instrument for the evaluation of CI.The aims of this study were to assess the cognitive status of MS patients by using the Lithuanian version of BICAMS, to evaluate the test-retest reliability of the Lithuanian version of BICAMS, and to measure the impact of CI on disability and duration of MS.Material/MethodsWe enrolled 50 MS patients and 20 cognitively normal control subjects, matched for age, gender, and level of education. Cognitive functions were assessed by the BICAMS tests, which include the Symbol Digit Modalities Test, the Brief Visuospatial Memory Test Revised, and the California Verbal Learning Test, 2nd edition.ResultsMS patients performed significantly worse than controls on the 3 neuropsychological tests of BICAMS (p<0.001). Younger and intellectually employed persons performed significantly better on these tests than older persons, manual workers, or unemployed persons (p<0.05). MS patients with higher disability scores tended to perform worse on the tests (p<0.05), but we found no relationship between BICAMS test scores and the duration of the disease or relapse rate (p>0.05). Test-retest reliability was excellent for all 3 subtests (r>0.8, p<0.05).ConclusionsOur study shows that BICAMS is a valid and acceptable cognitive assessment tool that can be recommended for routine use in Lithuania for assessing patients with MS.

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“…A lot of work is devoted to the standards of studying the arterial blood circulation with duplex ultrasound Doppler imaging [21][22][23]. The study of venous blood flow of head and neck is somewhat hampered due to technical complexity and lack of evaluation criteria [23][24][25], although some work on this issue already appears, in particular, devoted to the features of venous outflow in the patients with multiple sclerosis [26,27].…”

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confidence: 99%

Evaluation of the Effects of Acupuncture on Cerebral Hemodynamics in Patients Suffering from Cerebrovascular Pathology with Duplex Ultrasound Doppler Imaging

Kovalenko¹,

Chizhykova²,

Dzhura³

2018

UCMS

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The article presents the study results of thirty patients regarding the influence of acupuncture on cerebral hemodynamics with duplex ultrasound Doppler imagines. The reliable influence of acupuncture on the blood flow parameters of vertebrobasilar and carotid vessels has been revealed. For the purpose of in-depth study of vascular response to acupuncture in the patients with various diseases, the volunteers were divided into two groups: 1-patients, who had a stroke in anamnesis and were in the residual period (12 patients); 2-patients who suffered from vertebrogenic disturbance of blood flow in vertebrobasilar region (18 patients). The reliable data have been obtained on the positive response to acupuncture influence of cerebral blood flow and its differences in patients with different cerebrovascular pathology.

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Evaluation of Hemodynamic Properties of Cerebral Venous Drainage in Patients with Multiple Sclerosis: A Case-Control Study

Cited by 4 publications

References 37 publications

Lack of correlation between extracranial venous abnormalities and multiple sclerosis: a quantitative MRI study

Lack of correlation between extracranial venous abnormalities and multiple sclerosis: a quantitative MRI study

The BICAMS Battery for Assessment of Lithuanian-Speaking Multiple Sclerosis Patients: Relationship with Age, Education, Disease Disability, and Duration

Evaluation of the Effects of Acupuncture on Cerebral Hemodynamics in Patients Suffering from Cerebrovascular Pathology with Duplex Ultrasound Doppler Imaging

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