Evaluation of Hepatoprotective Activity of Tecoma stans Flowers

Kameshwara, S.; Kothai, A.R.; Jothimaniv, C.; Senthilkum, R.

doi:10.5567/pharmacologia.2013.236.242

Cited by 5 publications

(2 citation statements)

References 8 publications

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“…Earlier studies have reported two carotenoids and four glycosides from floral extracts ( Anand and Basavaraju, 2020 ). The crude extracts have been evaluated for antioxidant, anti-proliferative ( Marzouk et al, 2006 ), nephrotoxic ( Raju et al, 2011a , Raju et al, 2011b ), hepatoprotective ( Kameshwara et al, 2013 ), and antimicrobial ( Costantino et al, 2003 ) properties.…”

Section: Introductionmentioning

confidence: 99%

Alpha-glucosidase inhibitors from Nervilia concolor, Tecoma stans, and Bouea macrophylla

Nguyen

Mai

et al. 2022

Saudi Journal of Biological Sciences

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Section: Introductionmentioning

confidence: 99%

Alpha-glucosidase inhibitors from Nervilia concolor, Tecoma stans, and Bouea macrophylla

Nguyen

Mai

et al. 2022

Saudi Journal of Biological Sciences

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“…High antioxidant activity in flower extracts of different plants such as Tecoma stans , Hibiscus sabdariffa , Calendula officinalis , and Crocus sativus , were screened for hepatoprotective activity by the previous research and proved viable. [19–22]. …”

Section: Introductionmentioning

confidence: 99%

Radical Scavenging Activities of Lagerstroemia speciosa (L.) Pers. Petal Extracts and its hepato-protection in CCl4-intoxicated mice

Tiwary

Dutta

Dey

et al. 2017

BMC Complement Altern Med

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Background Lagerstroemia speciosa (L.) Pers. has medicinal importance. Bioactive phytochemicals isolated from different parts of L. speciosa, have revealed hypoglycemic, antibacterial, anti-inflammatory, antioxidant and hepato protective properties. Despite one report from Philippines detailing the use of L. speciosa as curative for fever and as well as diuretic, there is no experimental evidence about the hepatoprotective activity of the flower extracts.MethodsSeveral spectroscopic methods, including GC–MS, were used to characterize phytochemicals present in the petal extract of L. speciosa. Ethanol extract of petals was evaluated for anti-oxidant and free radical scavenging properties by using methods related to hydrogen atom transfer, single electron transfer, reducing power, and metal chelation. This study has also revealed the in vitro antioxidant and in vivo hepatoprotective properties of petal extract against carbon tetra chloride (CCl4)-induced liver toxicity in Swiss albino mice. Hepatoprotection in CCl4 -intoxicated mice was studied with the aid of histology and different enzymatic and non-enzymatic markers of liver damage. Cytotoxicity tests were done using murein spleenocytes and cancareous cell lines, MCF7 and HepG2.ResultGCMS of the extract has revealed the presence of several potential antioxidant compounds, of them γ-Sitosterol and 1,2,3-Benzenetriol (Pyrogallol) were the predominant ones. The antioxidants activities of the flower-extract were significantly higher than curcumin (in terms of Nitric oxide scavenging activity; p = 0.0028) or ascorbic acid (in terms of 2,2-Diphenyl-1-Picrylhydrazyl (DPPH) assay; p = 0.0022). The damage control by the flower extract can be attributed to the reduction in lipid peroxidation and restoration of catalase activity. In vitro cytotoxicity tests have shown that the flower extract did not affect growth and survivability of the cell lines. It left beyond doubt that a flower of L. speciosa is a reservoir of antioxidant and hepatoprotective agents capable of reversing the damage inflicted by CCl4-intoxication.ConclusionResults from the present study may be used in developing a potential hepato-protective health drink enriched with antioxidants from Lagerstroemia speciosa (L.) Pers.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-016-1495-0) contains supplementary material, which is available to authorized users.

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A review on phytochemistry and pharmacological uses of Tecoma stans (L.) Juss. ex Kunth

Anand

Basavaraju

2021

Journal of Ethnopharmacology

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Evaluation of Hepatoprotective Activity of Tecoma stans Flowers

Cited by 5 publications

References 8 publications

Alpha-glucosidase inhibitors from Nervilia concolor, Tecoma stans, and Bouea macrophylla

Alpha-glucosidase inhibitors from Nervilia concolor, Tecoma stans, and Bouea macrophylla

Radical Scavenging Activities of Lagerstroemia speciosa (L.) Pers. Petal Extracts and its hepato-protection in CCl4-intoxicated mice

A review on phytochemistry and pharmacological uses of Tecoma stans (L.) Juss. ex Kunth

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