Evaluation of hepatoprotective activity of aerial parts of Tephrosia purpurea L. and stem bark of Tecomella undulata

Khatri, Amit; Garg, Arun; Agrawal, S.

doi:10.1016/j.jep.2008.10.043

Cited by 71 publications

(44 citation statements)

References 16 publications

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“…Previous reports show flavonoids and steroids are responsible for hepatoprotective effect (Khatri et al, 2009;Panigrahi et al, 2010;Pattanayak et al, 2011;Singh & Gupta, 2011). The plant contains many bioactive substances such as flavonoids (vitexin, isovitexin, orientin, and isorientin), anthraquinones, particularly in roots (emodin and chrysophanol), carotenoids, vitamins (especially vitamin C), proteins, lipids, and organic acids.…”

Section: Discussionmentioning

confidence: 99%

Ameliorative effect of methanol extract ofRumex vesicariuson CCl₄-induced liver damage in Wistar albino rats

Ganaie

Khan

Siddiqui

et al. 2015

Pharmaceutical Biology

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Context: Rumex vesicarius L. (Polygonaceae), an edible plant, is reported to have many bioactive phytochemicals, especially flavonoids and anthraquinones with antioxidant and detoxifying properties.Objective: This study evaluated the methanolic extract of R. vasicarius (MERV) for hepatoprotective activity in rats against CCl 4 -induced liver damage. Materials and methods: The whole plant extract was prepared and investigated for its hepatoprotective activity. Rats were pretreated with MERV (100 and 200 mg/kg, p.o.) for 7 d prior to the induction of liver damage by CCl 4 . Animals were then sacrificed 24 h after CCl 4 administration for the biochemical (AST, ALT, and ALP activity in serum; lipid peroxidation (LPO) and glutathione (GSH) levels in liver tissue) and histological analyses. Results: CCl 4 -induced hepatotoxicity was confirmed by an increase (p50.05) in serum AST (4.55-fold), ALT (3.51-fold), and ALP (1.82-fold) activities. CCl 4 -induced hepatotoxicity was also manifested by an increase (p50.05) in LPO (3.88-fold) and depletion of reduced glutathione (3.14-fold) activity in liver tissue. The multiple dose MERV administration at 200 mg/kg showed promising hepatoprotective activity as evident from significant decrease levels of serum AST (230.01 ± 13.21), serum ALT (82.15 ± 5.01), serum ALP (504.75 ± 19.72), hepatic LPO (3.38 ± 0.33), and increased levels of hepatic glutathione (0.34 ± 0.04) towards near normal. Further, biochemical results were confirmed by histopathological changes as compared with CCl 4 -intoxicated rats. Discussion and conclusion: The results obtained from this study indicate hepatoprotective activity of Rumex plant against CCl 4 -induced liver toxicity; hence, it can be used as a hepatoprotective agent.

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Section: Discussionmentioning

confidence: 99%

Ameliorative effect of methanol extract ofRumex vesicariuson CCl₄-induced liver damage in Wistar albino rats

Ganaie

Khan

Siddiqui

et al. 2015

Pharmaceutical Biology

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“…There is evidence of pharmacological activity of extracts obtained from plants of Tephosia genus including toxic and lavicidal effects (Arriaga et al, 2009a;Lapointe et al, 2003), antifungal (Vijayan et al, 2008), anti-Helicobacter pylori (Chinniah et al, 2009), wound healing potential (Lodhi et al, 2006), hepatoprotective against thioacetamide-induced hepatotoxicity (Khatri et al, 2009), antihyperglycemic and antihyperlipidemic in streptozotocin induced diabetic rats (Pavana et al, 2007), alleviates phorbol ester-induced tumor promotion response in murine skin , ameliorates N-diethylnitrosamine and potassium bromate-mediated renal oxidative stress and toxicity in rats (Khan et al, 2001), reduction in the severity of lithium-pilocarpine induced status epilepticus (Asuntha et al, 2010) and a flavonoidal fraction of T. purpurea inhibits sheep red blood cells-induced delayed-type hypersensitivity reactions (Damre et al, 2003). Thus, there are some pharmacological studies on the Tephosia genus activities.…”

Section: Discussionmentioning

confidence: 99%

Tephrosia sinapou extract reduces inflammatory leukocyte recruitment in mice: effect on oxidative stress, nitric oxide and cytokine production

Martínez

Zarpelon

Zimermann

et al. 2012

Rev. bras. farmacogn.

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Abstract:Tephrosia toxicaria (Sw.) Pers., which is currently known as T. sinapou (Buc'hoz) A. Chev., Fabaceae, is a source of compounds such as fl avonoids, however, few studies addressed the anti-infl ammatory and antioxidant effects of T. sinapou. Therefore, we evaluated the antioxidant mechanisms of the T. sinapou ethyl acetate extract in vitro, and whether the extract affects leukocyte recruitment in four models of infl ammation and the involvement of nitric oxide and cytokines in its mechanism. In vitro, it was observed that the extract presented hydrogen donating ability to 2,2-diphenyl-1-picryl-hydrazyl radical (DPPH • ), 2,2'-azino-di-(3-ethylbenzthiazoline-6-sulphonic acid) radical (ABTS + ), and also effi ciently inhibited iron-dependent and independent lipid peroxidation and iron chelation assays. In vivo, it inhibited the recruitment of total leukocytes and neutrophil induced by carrageenin, zymosan, glycogen and lipopolysaccharide in the peritoneal cavity of mice. Two mechanisms were detected: 1) T. sinapou effect on leukocyte recruitment depends on nitric oxide since was dose-dependently inhibited by treatment with L-NAME (nitric oxide synthase inhibitor), and 2) the extract also inhibited the production of crucial cytokines for the leukocyte recruitment; tumor necrosis factor α and interleukin-1β. Concluding, T. sinapou ethyl acetate extract reduces oxidative stress in vitro, and infl ammatory leukocyte recruitment by a mechanism related to inhibition of cytokine production, and in a nitric oxide dependent manner in vivo.

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“…(Family, Bignoniaceae), has been considered as a valuable agroforestry tree in most arid and semiarid areas for the very high quality of timber with its use as fuel wood and fodder. This is commonly known as Rohira, Rohitaka, and Rohida and has long been used extensively to cure and treat many diseases in both folk and classical stream since long [16]. The plant had been revealed to possess a wide range of biological properties because of the presence of several pharmacologically important phytocomponents such as radermachol [17], clutyl ferulate [18], lapachol [19], β-lapachone [20], α-lapachone [21], and many more which are responsible for the curative action on different diseases such as central analgesic [22], Rohilla et al…”

Section: Introductionmentioning

confidence: 99%

“…abortifacient [23], hepatoprotective [24], antimicrobial [25], and many more including diabetes [26,27] as well as other potential health profits.…”

Section: Introductionmentioning

confidence: 99%

In-Vitro Hypoglycemic Evaluation of Fractions of Hydro-Acoholic Extract of Heartwood of Tecomella Undulata Linn.

Garg¹,

Rohilla²,

Garg³

2017

Asian J Pharm Clin Res

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Objective: The objective of this study was to screen alpha-amylase and alpha-glucosidase inhibitors from the different fractions of crude hydroalcoholic extract of heartwood of Tecomella undulata Linn.Methods: Four fractions of crude hydroalcoholic extract of heartwood of plant were used for in-vitro inhibitory assays against digestive enzymes: Alpha-amylase and alpha-glucosidase. For assay, different concentrations (20,40, 60, 80, and 100 µg/ml) were used for all fractions. A standard protocol was used for preliminary phytochemical screening of different bioactive components present in all fractions. Results:The fractions have shown moderate to highest inhibitory activity against both enzymes. However, the strong inhibition was revealed by acetone fraction against alpha-amylase with very minimal inhibitory concentrations at inhibitory concentration 50% values when compared with a standard drug acarbose. Several medicinally active phytocomponents such as flavonoids, saponin, anthraquinones, tannins, triterpenoids, and phenols were observed in all studied fractions. Conclusion:The different fractions prepared from crude hydroalcoholic extract of heartwood of plant are capable of inhibiting alpha-amylase and alpha-glucosidase, and it can be concluded that heartwood of T. undulata Linn. is partially active against postprandial hyperglycemia, thus diabetes mellitus.

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Evaluation of hepatoprotective activity of aerial parts of Tephrosia purpurea L. and stem bark of Tecomella undulata

Cited by 71 publications

References 16 publications

Ameliorative effect of methanol extract ofRumex vesicariuson CCl₄-induced liver damage in Wistar albino rats

Ameliorative effect of methanol extract ofRumex vesicariuson CCl₄-induced liver damage in Wistar albino rats

Tephrosia sinapou extract reduces inflammatory leukocyte recruitment in mice: effect on oxidative stress, nitric oxide and cytokine production

In-Vitro Hypoglycemic Evaluation of Fractions of Hydro-Acoholic Extract of Heartwood of Tecomella Undulata Linn.

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Evaluation of hepatoprotective activity of aerial parts of Tephrosia purpurea L. and stem bark of Tecomella undulata

Cited by 71 publications

References 16 publications

Ameliorative effect of methanol extract ofRumex vesicariuson CCl4-induced liver damage in Wistar albino rats

Ameliorative effect of methanol extract ofRumex vesicariuson CCl4-induced liver damage in Wistar albino rats

Tephrosia sinapou extract reduces inflammatory leukocyte recruitment in mice: effect on oxidative stress, nitric oxide and cytokine production

In-Vitro Hypoglycemic Evaluation of Fractions of Hydro-Acoholic Extract of Heartwood of Tecomella Undulata Linn.

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Ameliorative effect of methanol extract ofRumex vesicariuson CCl₄-induced liver damage in Wistar albino rats

Ameliorative effect of methanol extract ofRumex vesicariuson CCl₄-induced liver damage in Wistar albino rats