Evaluation of Hepatoprotective and Antioxidant Activity of Isolated Flavonoids Compounds from Ougeinia oojeinensis extracts

Abstract

The flavonoids present in plant grant different kinds of pharmacological action. It has been reported that the flavonoids assume boss job in assurance of harm liver. Subsequently we wanted to research the hepatoprotective and cancer prevention agent action of segregated flavonoids mixes from Ougeinia oojeinensis leaves extracts. The oil ether, ethanol and watery extracts were set up from leaves of Ougeinia oojeinensis, and screened for phytochemical investigation. The diverse flavonoid compound disengaged from ethanol separate, and further assessed their hepatoprotective and cancer prevention agent movement in CCl4 prompted hepatotoxicity. The most extreme phytoconstituents alongside flavonoids were seen in ethanol extract of leaves of Ougeinia oojeinensis. The nine distinct divisions were isolated and dried from ethanol extracts of Ougeinia oojeinensis. The F8 and F9 demonstrate the nearness of flavonoids, tannins and phenolic mixes. The F8 and F9 indicates intense hepatoprotective action by essentially diminishing the CCl4 prompted modification in SGOT, SGPT, ALP, ACP, all out bilirubin and direct bilirubin in blood. The cancer prevention agent movement of F8 and F9 affirmed on altogether expanding in dimension of catalase, glutathione peroxidase, superoxide dismutase compound, while lipid peroxidation was diminished, when contrasted with CCl4 condition. The consequence of study recommends that the flavonoid compound F9 of Ougeinia oojeinensis showed most extreme hepatoprotective and cell reinforcement action thought about F8.