Evaluation of hepatoprotective and invitro cytotoxic activity of leaves of <i>Chrozophora plicata</i> Linn

The number of cancer cases will reach 24 million in 2040, according to the International Agency for Research on Cancer. Current treatments for cancer are not effective and selective for most patients; for this reason, new anticancer drugs need to be developed and researched enough. There are potentially useful drugs for cancer isolated from plants that are being used in the clinic. Available information about phytochemistry, traditional uses, in vitro and in vivo experiments with plants, and pure compounds isolated from the Euphorbiaceae family indicates that this family of plants has the potential to develop anticancer drugs. This review examines selected species from the Euphorbiaceae family and their bioactive compounds that could have potential against different types of cancer cells. It reviews the activity of crude extracts, isolated compounds, and nanoparticles and the potential underlying mechanisms of action.

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In-vitro Screening for Cytotoxic Activity of Herbal Plant Extracts on N2a Cell Lines

G¹,

Rasheed²,

Vinukonda

et al. 2021

RJPT

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Clitoria ternatea, Cucurbita maxima, Artemisia vulgaris were the Indian native plants used in the treatment of different diseases. The methanolic extract of Clitoria ternatea, petroleum ether extract of Cucurbita maxima and methanolic extract of Artemisia vulgaris were investigated using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay. These extracts were assessed using N2a cell line (Neuroblastoma). Cisplatin was used as a positive control based on IC50 values. Artemisia vulgaris methanol extract have highest cytotoxicity (80.81ug/mL) and Cucurbita maxima seed extract have lowest cytotoxicity (57.655ug/mL). The comparison of IC50 of the extracts had shown the following toxicity: Cucurbita maxima petroleum ether extract <Clitoria ternatea methanolic extract <Artemisia vulgaris methanolic extract. The Cucurbita maxima showed least cytotoxicity against the tested cell lines. The results indicate that Cucurbita maxima seed extract have significant potential to be used as a natural anticancer agent in cultured N2a cell lines.

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Evaluation of hepatoprotective and invitro cytotoxic activity of leaves of Chrozophora plicata Linn

Cited by 4 publications

References 0 publications

Plants used for the treatment of icterus (jaundice) in Central India: A review

Plants used for the treatment of icterus (jaundice) in Central India: A review

Nature’s Green Potential: Anticancer Properties of Plants of the Euphorbiaceae Family

In-vitro Screening for Cytotoxic Activity of Herbal Plant Extracts on N2a Cell Lines

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