Evaluation of hepatoprotective effect of chloroform and methanol extracts of &lt;i&gt;Opuntia monacantha&lt;/i&gt; in paracetamol-induced hepatotoxicity in rabbits

Saleem, Mohammad; Irshad, Iram; Baig, MK; Naseer, Faiza

doi:10.3329/bjp.v10i1.20825

Cited by 9 publications

(4 citation statements)

References 16 publications

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“…There were several other recorded plants whose in vitro pharmacological effects have been investigated and found to correlate with the information provided by the TMPs. These include antibacterial and antifungal effects of O. rochetiana used in the management of urinary tract infections and oral candidiasis,[ 32 ] hypoglycemic/hepatoprotective effects of O. monacantha used in the treatment of diabetes and pancreatitis,[ 33 34 ] and spasmolytic effects of A. hybridus used to relieve colic pains and abdominal upsets. [ 35 ] Others include gastroprotective effects of N. officinale ,[ 36 ] antimicrobial effects of Aloe, Cleome , and Ipomoea , spp.,[ 36 37 38 ] and hepatoprotective effects of Ficus , Kalanchoe , Momordica , and Rhus spp.…”

Section: Discussionmentioning

confidence: 99%

Medicinal plants used by traditional healers in Sangurur, Elgeyo Marakwet County, Kenya

Kigen¹,

Kipkore²,

Wanjohi³

et al. 2017

Phcog Res

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Background:Although herbal medical products are still widely used in Kenya, many of the medicinal plants used by traditional medical practitioners (TMPs) have not been documented, despite several challenges that are now threatening the sustainability of the practice.Objective:To document the medicinal plants and healing methods used by TMPs in a region of Kenya with several recognized herbalists for potential research.Materials and Methods:Semi-structured interviews, group discussions, and direct observations were used to collect ethnopharmacological information. The participant's bio-data, clinical conditions treated, methods of treatment, medicinal plants used, methods of preparation and administration, and dosage forms were recorded.Results:A total of 99 medicinal plants and 12 complementary preparations employed in the treatment of 64 medical conditions were identified. The most widely used plant was Rotala tenella which was used to treat nine medicinal conditions; seven each for Aloe tweediae and Dovyalis abyssinica; and six each for Basella alba and Euclea divinorum. The plants belonged to 55 families with Fabaceae family being the most frequently used (10), followed by Apocynaceae and Solanaceae, each with six species, respectively. We identified plants used to determine the sex of an unborn baby and those used to treat several conditions including anthrax and cerebral malaria and herbs used to detoxify meat from an animal that has died from anthrax. Of special interest was R. tenella which is used to prevent muscle injury.Conclusions:We have documented several plants with potential therapeutic effects. Further research may be conducted to determine their efficacy.SUMMARY The medicinal plants used by traditional healers in a community which still practices herbal medicine in Kenya were documented. A total of 99 medicinal plants and 12 complementary preparations employed in the treatment of 64 medical conditions were identified. Further research may be carried out in order to determine their therapeutic efficacies. Abbreviations Used: Fic: Informant consensus factor, Nur: Number of use reports in each category, Ns: Number of reported species, TMPs: Traditional medical practitioners.

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Section: Discussionmentioning

confidence: 99%

Medicinal plants used by traditional healers in Sangurur, Elgeyo Marakwet County, Kenya

Kigen¹,

Kipkore²,

Wanjohi³

et al. 2017

Phcog Res

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“…The results showed that both extracts at 200, 400, and 600 mg/kg of body weight in the 1-week protocol showed significant hepatoprotective activity, as they reduced ALT, AST, ALP, and total bilirubin levels; in addition, no histopathological changes were observed in the liver tissue. The authors associated these results with the presence of polyphenols, flavonoids, alkaloids, tannins, saponins, and polysaccharides, without detailing the possible mechanisms of action of these constituents [77].…”

Section: Animal Model Studiesmentioning

confidence: 99%

Exploring the Potential Hepatoprotective Properties of Cactus (Cactaceae) in Liver Health and Disease Management: A Brief Review

Vieira,

Ferreira,

Araújo

et al. 2024

Livers

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Cacti are renowned for their resilience in arid environments and have been utilized as a valuable food source in various cultures for centuries. The potential effects of cactus (Cactaceae) consumption on liver health have garnered significant scientific interest in recent years. This review aimed to consolidate and analyze existing research findings regarding the relationship between cactus-derived compounds and their influence on liver function and health. Various cactus species, particularly Opuntia spp., are rich reservoirs of antioxidants, polyphenols, flavonoids, and betalains. In vitro and in vivo studies with animal models have shown that bioactive constituents of cactus exhibit anti-inflammatory, antioxidative, and antifibrotic properties, which potentially mitigate liver damage induced by oxidative stress, inflammation, and hepatotoxic agents. Understanding their mechanisms of action and conducting rigorous clinical studies with administration of cactus will ascertain their role in preventing and treating liver ailments, offering novel avenues in nutrition, hepatology, and natural medicine.

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“…There are a growing number of studies purporting hepatoprotective effects with traditional medicines, and based on claims in folkloric use, several medicinal plants have been evaluated scientifically with promising hepatoprotective activity. These plants include Adansonia digitata [ 1 ], Alysicarpus vaginalis [ 2 ], Bidens pilosa [ 3 ], Brassica oleracea [ 4 ], Cineraria abyssinica [ 5 ], Indigofera barberi [ 6 ], Justicia schimperiana [ 7 ], Nigella sativa [ 8 ], Opuntia monacantha [ 9 ], Verbascum sinaiticum [ 7 ], Vicia calcarata [ 10 ], Ziziphus jujuba [ 11 ]. In recent years, hepatoprotective natural antioxidants and compounds with radical-scavenging activity have been identified, including curcumin and ginger [ 12 ], Hibiscus species [ 13 ] Polyalthia longifolia [ 14 ] and Cassia italic [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of hepatoprotective and antidiarrheal activities of the hydromethanol crude extract and solvent fractions of Schinus molle L. (Anacardiaceae) leaf and fruit in mice

Belayneh,

Mengistu,

Hailay

2024

Metabolism Open

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Evaluation of hepatoprotective effect of chloroform and methanol extracts of <i>Opuntia monacantha</i> in paracetamol-induced hepatotoxicity in rabbits

Cited by 9 publications

References 16 publications

Medicinal plants used by traditional healers in Sangurur, Elgeyo Marakwet County, Kenya

Medicinal plants used by traditional healers in Sangurur, Elgeyo Marakwet County, Kenya

Exploring the Potential Hepatoprotective Properties of Cactus (Cactaceae) in Liver Health and Disease Management: A Brief Review

Evaluation of hepatoprotective and antidiarrheal activities of the hydromethanol crude extract and solvent fractions of Schinus molle L. (Anacardiaceae) leaf and fruit in mice

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