Evaluation of hepatoprotective potential of jigrine post-treatment against thioacetamide induced hepatic damage

Ahmad, Aftab; Pillai, K. K.; Najmi, Abul Kalam; Ahmad, Shibli Jameel; Pal, SN; Balani, D. K.

doi:10.1016/s0378-8741(01)00349-x

Cited by 60 publications

(55 citation statements)

References 20 publications

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“…This increased level of serum bilirubin is due to excessive production of bilirubin because of breakdown of RBCs and the inability of animal to excrete bilirubin due to liver damage [29]. The increase of plasma bilirubin levels by CCl 4 further confirmed that CCl 4 is toxic for liver which agrees with Ahsan et al [16]; Vogel [30]; Samudram et al [31].…”

Section: Plasma Bilirubin Levelsupporting

confidence: 83%

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Polygonum amplexicaule Extract: An Effective Herbal Cure to CCl4 Induced Liver Damage In Vivo

Maqsood¹,

Ibrahim²,

Farooqı³

et al. 2017

J Rare Disord Diagn Ther

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Section: Plasma Bilirubin Levelsupporting

confidence: 83%

“…ALP is present in hepatocytes plasma membrane and elevation in ALP level is related directly to the damage in liver cell membrane [28,29]. Elevated level of ALP in toxic condition and reduced level in case of treatment with drug and extracts of P. amplexicaule is shown.…”

Section: Alp Activitymentioning

confidence: 94%

Polygonum amplexicaule Extract: An Effective Herbal Cure to CCl4 Induced Liver Damage In Vivo

Maqsood¹,

Ibrahim²,

Farooqı³

et al. 2017

J Rare Disord Diagn Ther

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“…The levels of these antioxidant enzymes were restored upon pretreatment with lycopene. GSH, an important endogenous antioxidant found particularly in high concentrations in liver and known to have key functions in protective processes against cellular lipid peroxidation (Ahmad et al, 2002). GSH counters oxidative stress by eliminating the compounds responsible for lipid peroxidation or by increasing the efficiency of NADPH that protects detoxifying enzymes.…”

Section: Discussionmentioning

confidence: 99%

Effect of lycopene on oxidative stress induced duringd-galactosamine/lipopolysaccharide-sensitized liver injury in rats

Abdulazeez

Devaki

2013

Pharmaceutical Biology

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Context: Lycopene is a phytonutrient under considerable investigation for its antioxidant benefits in treating diseases like cancer, cardiovascular diseases, osteoporosis and diabetes. Objective: This study explores the effect of lycopene against oxidative damage during experimental hepatitis, induced by D-galactosamine/lipopolysaccharide (D-GalN/LPS). Materials and methods: Experimental rats were pretreated with lycopene intraperitoneally for 6 d (10 mg/kg body weight/day) and then induced by D-GalN/LPS. After induction, the levels of lipid peroxides in serum and liver of control and experimental group of animals were measured. The activities of enzymatic antioxidants such as superoxide dismutase, catalase, glutathione peroxidase and glutathione S-transferase and nonenzymatic antioxidants, such as reduced glutathione, vitamin C and vitamin E were also analyzed. The genotoxic effect of D-GalN/LPS was evaluated through the comet assay. Results: The elevated level of lipid peroxides induced by D-GalN/LPS was significantly (p50.05) reverted in lycopene pretreated animals. Lycopene administration restored (p50.05) the decreased activities of enzymatic and nonenzymatic antioxidant markers during D-GalN/LPS induction. The DNA strand breaks (72.3 mM) generated during D-GalN/LPS toxic injury was significantly reduced (35.5 mM) upon pretreatment with lycopene as observed by reduced tail movement in comet assay. Discussion and conclusion: There is no conclusive report about lycopene-assisted protection against free radical mediated toxic injury induced by D-GalN/LPS. Our findings reveal that lycopene effectively combated oxidative damage and protected antioxidant defense status of the cell. Pretreatment of lycopene also offers protection against the DNA damage and confirms the antioxidant nature of the phytonutreint against experimental hepatitis.

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“…Rise of serum enzymes indicates the harmful effects of CCl 4 on liver of animals, because these enzymes are localized in cytoplasm and released after cellular damage (Mohan et al, 2007). The increased level of serum bilirubin might be due to inconsistent production of bilirubin due to excessive breakdown of red blood cells (RBCs) and the incapacity of animal to handle bilirubin due to liver damage which would cause either intra or extra hepatic obstruction (Ahmad et al, 2002). The increase of plasma bilirubin levels by CCl 4 further indicates that CCl 4 is a toxic agent for liver which is also in agreement with results reported by Vogel (2002), Samudram et al (2008), Ahsan et al (2009) and Tsala et al (2010).…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective effects of Justicia adhatoda L. against carbon tetrachloride (CCl4) induced liver injury in Swiss albino mice

Afzal¹

2013

Afr. J. Pharm. Pharmacol.

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Medicinal plants are believed to be a precious natural reservoir and have been continuously studied for their pharmacological activities against various ailments, liver being no exception. Leaves of Justicia adhatoda L. are being extensively used against many human ailments. Hepatoprotective effects of J. adhatoda L. leaves and flowers were investigated on carbon tetrachloride (CCl 4 ) induced liver damage in Swiss albino mice. Liver injury was assessed by estimation of biochemical parameters which includes liver function tests and supplemented by histopathological examination of liver. Aqueous, ethanolic and methanolic extracts of different concentrations were given orally and activities of these extracts were compared with standard drug (silymarin). The results showed that J. adhatoda leaves and flowers showed unambiguous hepatoprotective activity against CCl 4 induced liver toxicity. It was also concluded that different concentrations of leaves and flowers of J. adhatoda did not show any sign and symptoms of toxicity and mortality.

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Evaluation of hepatoprotective potential of jigrine post-treatment against thioacetamide induced hepatic damage

Cited by 60 publications

References 20 publications

Polygonum amplexicaule Extract: An Effective Herbal Cure to CCl4 Induced Liver Damage In Vivo

Polygonum amplexicaule Extract: An Effective Herbal Cure to CCl4 Induced Liver Damage In Vivo

Effect of lycopene on oxidative stress induced duringd-galactosamine/lipopolysaccharide-sensitized liver injury in rats

Hepatoprotective effects of Justicia adhatoda L. against carbon tetrachloride (CCl4) induced liver injury in Swiss albino mice

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