Evaluation of hepatoprotective potential of ethanolic extract of Ixora pavetta against isoniazid and rifampicin induced hepatotoxicity in rats

Reddy, Gangavaram Jyothi; Reddy, Vara Prasanth; Sreepavani, Mungura; Rajaram, C.; Kumar, Sadhu Nelson; Kanhere, Rupesh S.

doi:10.1016/j.dit.2013.06.007

Cited by 5 publications

(1 citation statement)

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“…Co-administration of INH+RIF for 21 days caused a significant increase in the serum levels of DB, TB, ALT, AST, ALP, LDH and TSP. The findings of this study are in agreement with numerous reports that document a rise in the activity of these serum enzymes [31–33]. However, the exact mechanism of hepatotoxicity by INH+RIF is still not clear, although some researchers have suggested that hepatotoxicity is mediated through release of reactive/toxic metabolites that bind covalently to the macromolecules of hepatocytes [34].…”

Section: Discussionsupporting

confidence: 91%

Hepatoprotective Activity of Melittin on Isoniazid and Rifampicin Induced Liver Damage in Male Albino Rats

Naji

Al-Khatib

Al-Haj

et al. 2020

Preprint

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ObjectiveThe present study aimed to investigate the ameliorative effect of melittin, a major polypeptide in the venom of honeybee (Apis mellifera) on isoniazid (INH) and rifampicin (RIF) induced hepatotoxicity in male albino rats. Method: The rats (140-200g) were divided into five groups (n=6): normal control (NC); toxic (T) group treated with INH+RIF (100 mg/kg, p.o.); melittin-treated (Mel15, Mel30) group (15 or 30 µg/kg s.c); and normal recovery (NR) group. Blood and liver samples were collected for biochemical, hematological and histopathological studies respectively.ResultsThe administration of melittin was found to prevent the antitubercular drug-induced alterations in the diagnostic markers; reduced glutathione (GSH), direct bilirubin (DB), total bilirubin (TB), aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), and total serum protein (TSP). Besides, hematological alterations were significantly high (P<0.0001) in Mel-treated groups when compared to the toxic control. The NR group exhibited lower levels of DB, TB, ALP, LDH and TSP. In addition, treatment with melittin offered protection in the NR group with respect to MDA levels.ConclusionEvidence from this study indicate that melittin is beneficial for the prevention of acute hepatic failure in antitubercular drug-induced hepatoxicity.

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Section: Discussionsupporting

confidence: 91%