Evaluation of hepatotoxic and genotoxic potential of silver nanoparticles in albino rats

Mahdy, Magdy Mohamed El; El-Din, Taher A. Salah; Aly, Halima Sayed; Mohammed, Faten F.; Shaalan, Mohamed

doi:10.1016/j.etp.2014.09.005

Cited by 150 publications

(92 citation statements)

References 36 publications

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“…Among the oxidative stress-related changes caused by AgNPs, depletion of reduced glutathione (GSH) has been observed in human skin carcinoma cells [6], rat liver cells [60], mouse macrophage cells [100], human liver cells [106,141] and mouse embryonic fibroblasts [74]. Results of studies on aquatic organisms strongly support these in vitro observations [3,38,86], whereas limited in vivo studies demonstrate a lack of changes in GSH levels in liver of exposed rodents [32,39].…”

Section: -Body Weight Gsh -Reduced Glutathione Ige -Immunoglobulin supporting

confidence: 58%

“…Adverse effects were observed including marked pathological changes in liver morphology [32,67,71], changes in liver enzyme activities [2,56,99], changes in the level of plasma lipids [30,67], generation of ROS [30,103] and inflammatory response [25,99]. Autophagy and apoptosis have been confirmed to play roles in mediating hepatotoxicity [71].…”

Section: Toxic Effects Of Silver Nanoparticles In Mammalsmentioning

confidence: 99%

“…Table III lists studies demonstrating the negative influence of AgNPs in mammalian organisms. A series of studies has shown that systematically administered AgNPs cause inflammatory and cytotoxic effects including pulmonary toxicity after prolonged inhalation [132] and hepatotoxicity after prolonged oral [30,67,103], intravenous [25] or intraperitoneal [32] administration. Moreover, histopathological changes in kidneys and increasing levels of creatinine have been reported [33,119], indicating that AgNPs may cause nephrotoxic effects.…”

Section: Toxic Effects Of Silver Nanoparticles In Mammalsmentioning

confidence: 99%

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Toxic effects of silver nanoparticles in mammals – does a risk of neurotoxicity exist?

Skalska¹,

Strużyńska²

2015

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A b s t r a c t Over the last decade, silver nanoparticles have become an important class of nanomaterials utilized in the development of new nanotechnologies. Despite the fact that nanosilver is used in many commercial applications, our knowledge about its associated risks is incomplete. Although a number of studies have been undertaken to better understand the impact of silver nanoparticles on the environment, aquatic organisms and cell lines, little is known about their side effects in mammalian organisms. This review summarizes relevant data and the current state of knowledge regarding toxicity of silver nanoparticles in mammals, as well as the accumulated evidence for potent neurotoxic effects. The influence of nanosilver on the central nervous system is significant because of evidence indicating that it accumulates in mammalian brain tissue.

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Section: -Body Weight Gsh -Reduced Glutathione Ige -Immunoglobulin supporting

confidence: 58%

Section: Toxic Effects Of Silver Nanoparticles In Mammalsmentioning

confidence: 99%

Section: Toxic Effects Of Silver Nanoparticles In Mammalsmentioning

confidence: 99%

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Toxic effects of silver nanoparticles in mammals – does a risk of neurotoxicity exist?

Skalska¹,

Strużyńska²

2015

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“…The solution turned turbid if in presence of non-reacted Ag free ions. Formation of totally clear golden yellow solution reveals that all the free Ag ions were reacted forming Ag nanoparticles [9,10].…”

Section: Synthesis Of Silver Nanoparticlesmentioning

confidence: 99%

Untitled

2016

JNMR

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This study represents a real field study on some orchards in two different Egyptian governorates namely Menofiea and Beheira to find out the problems related to quality degradation and cosmetic issues of citrus fruit. The study is based on Isolation, identification and prevention of the fungal pathogens that are involved in citrus AbstractPathogenic Fungal infections have tremendous harmful effects on human health and economy. Citrus fruit crop has an immense economic, social and Health impact on human all over the world. Citrus fruits are attacked by a number of pathogens from bloom to harvesting stage and subsequently by post-harvest pathogens that affect fruit yield and considerably deteriorate the fruit quality. In the present work, survey was conducted during 2014 and 2015 to evaluate the incidence of citrus leave spots and fruit decay in some orchards in Menofiea and Beheira governorates, Egypt. Three different fungi were isolated from samples of citrus. Alternaria alternata was the most abundant fungal pathogen isolated from citrus leaf and fruit spots followed by Alternaria citri and Penicillium digitatum. Silver nanoparticles were tested as a potent fungicide that may replace the dangerous cytotoxic fungicides. Silver nanoparticles were synthesized with 10 ± 5 nm average diameter size. In vitro assay was carried out on Potato Dextrose Agar (PDA) media treated with 50, 100 and 150ppm of silver nanoparticles in addition to two control traditional fungicides products, namely Iprodione and Difenoconazole at 150 ppm concentrations. Results revealed that Silver nanoparticle, 150 ppm, showed potent antifungal activity against the isolated fungi that will open the gate of new generation of less harmful fungicides replacing the cytotoxic dangerous currently used fungicides.

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“…We synthesized silver nanoparticles by chemical reduction of silver nitrate according to the protocol of El Mahdy et al (2015). Both sodium citrate tribasic hydrate and sodium borohydride were utilized as reducing agents, and polyvinyl pyrrolidone as a stabilizing agent to prevent particle agglomeration (Wang et al 2005).…”

Section: Silver Nanoparticlesmentioning

confidence: 99%

Antiprotozoal effects of metal nanoparticles againstIchthyophthirius multifiliis

et al. 2017

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S U M M A R YIchthyophthirius multifiliis is a widespread, ciliated protozoan ectoparasite of fish. In the present study, we investigated the effects of metal nanoparticles on the reproduction and infectivity of free-living stages of I. multifiliis. We determined that ∼50% of theronts could be killed within 30 min of exposure to either 20 ng mL −1 gold, 10 ng mL −1 silver or 5 ng mL −1 zinc oxide nanoparticles. Silver and zinc oxide nanoparticles at concentration of 10 and 5 ng mL −1 killed 100 and 97% of theronts, respectively and inhibited reproduction of tomonts after 2 h exposure. Gold nanoparticles at 20 ng mL killed 80 and 78% of tomonts and theronts 2 h post exposure, respectively. In vivo exposure studies using rainbow trout (Oncoryhnchus mykiss) demonstrated that theronts, which survived zinc oxide nanoparticles exposure, showed reduced infectivity compared with control theronts. No mortalities were recorded in the fish groups cohabited with theronts exposed to either nanoparticles compared with 100% mortality in the control group. On the basis of the results obtained from this study, metal nanoparticles particularly silver nanoparticles hold the best promise for the development of effective antiprotozoal agents useful in the management of ichthyophthiriosis in aquaculture.

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Evaluation of hepatotoxic and genotoxic potential of silver nanoparticles in albino rats

Cited by 150 publications

References 36 publications

Toxic effects of silver nanoparticles in mammals – does a risk of neurotoxicity exist?

Toxic effects of silver nanoparticles in mammals – does a risk of neurotoxicity exist?

Untitled

Antiprotozoal effects of metal nanoparticles againstIchthyophthirius multifiliis

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