Evaluation of herb-drug interaction of a polyherbal Ayurvedic formulation through high throughput cytochrome P450 enzyme inhibition assay

Pandit, Subrata; Kanjilal, Satyajyoti; Awasthi, Anshumali; Chaudhary, Anika; Banerjee, D. P. K.; Bhatt, Bibhuti Nath; Narwaria, Avinash; Singh, Rahul; Dutta, Kakoli; Jaggi, Manu; Singh, Anu; Sharma, Neena; Katiyar, Chandra Kant

doi:10.1016/j.jep.2016.07.061

Cited by 25 publications

(7 citation statements)

References 21 publications

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“…The extract of A. paniculata, as well as its major compound, andrographolide, underwent studies on their interaction with the CYP family, both in vitro and in vivo ( Table 3 ). It has been reported that approximately 50% of the drug metabolism is taken up by CYP3A4 [ 184 ]. In the in vitro studies, it was found that the ethanolic and methanolic extracts, andrographolide and 14-deoxy-11,12-didehydroandrographolide, inhibited the activity of the CYP 3A4 isozyme [ 185 , 186 , 187 ].…”

Section: Resultsmentioning

confidence: 99%

A Comprehensive Review of Andrographis paniculata (Burm. f.) Nees and Its Constituents as Potential Lead Compounds for COVID-19 Drug Discovery

Intharuksa

Arunotayanun²,

Yooin

et al. 2022

Molecules

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The COVID-19 pandemic has intensively disrupted global health, economics, and well-being. Andrographis paniculata (Burm. f.) Nees has been used as a complementary treatment for COVID-19 in several Asian countries. This review aimed to summarize the information available regarding A. paniculata and its constituents, to provide critical points relating to its pharmacological properties, safety, and efficacy, revealing its potential to serve as a source of lead compounds for COVID-19 drug discovery. A. paniculata and its active compounds possess favorable antiviral, anti-inflammatory, immunomodulatory, and antipyretic activities that could be beneficial for COVID-19 treatment. Interestingly, recent in silico and in vitro studies have revealed that the active ingredients in A. paniculata showed promising activities against 3CLpro and its virus-specific target protein, human hACE2 protein; they also inhibit infectious virion production. Moreover, existing publications regarding randomized controlled trials demonstrated that the use of A. paniculata alone or in combination was superior to the placebo in reducing the severity of upper respiratory tract infection (URTI) manifestations, especially as part of early treatment, without serious side effects. Taken together, its chemical and biological properties, especially its antiviral activities against SARS-CoV-2, clinical trials on URTI, and the safety of A. paniculata, as discussed in this review, support the argument that A. paniculata is a promising natural source for drug discovery regarding COVID-19 post-infectious treatment, rather than prophylaxis.

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Section: Resultsmentioning

confidence: 99%

A Comprehensive Review of Andrographis paniculata (Burm. f.) Nees and Its Constituents as Potential Lead Compounds for COVID-19 Drug Discovery

Intharuksa

Arunotayanun²,

Yooin

et al. 2022

Molecules

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show abstract

“…Drug interactions during the metabolic process can mainly occur inhibition or induction of those enzymes by other CYP substrates [22]. Most drugs are metabolized by the CYP3A4, CYP1A2, CYP2C9, CYP2D6, CYP2E1, and CYP2C19, and CYP3A4 is responsible for approximately 50% of the entire drug metabolism [24]. In addition, those CYP enzymes are expressed in other hepatic tissues like enterocytes of the intestine and even whole brain tissues and the BBB.…”

Section: Hepatic Metabolism and Bile Excretionmentioning

confidence: 99%

Impacts of Drug Interactions on Pharmacokinetics and the Brain Transporters: A Recent Review of Natural Compound-Drug Interactions in Brain Disorders

Khadka

Lee

Park

et al. 2021

IJMS

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Natural compounds such as herbal medicines and/or phyto-compounds from foods, have frequently been used to exert synergistic therapeutic effects with anti-brain disorder drugs, supplement the effects of nutrients, and boost the immune system. However, co-administration of natural compounds with the drugs can cause synergistic toxicity or impeditive drug interactions due to changes in pharmacokinetic properties (e.g., absorption, metabolism, and excretion) and various drug transporters, particularly brain transporters. In this review, natural compound–drug interactions (NDIs), which can occur during the treatment of brain disorders, are emphasized from the perspective of pharmacokinetics and cellular transport. In addition, the challenges emanating from NDIs and recent approaches are discussed.

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“…To ensure the content uniformity of phytoconstituents across batches in a polyherbal formulation, single or multiple marker compounds are used. Numerous studies reported the use of chromatographic fingerprinting as a potential tool for standardizing complex polyherbal formulations [12][13][14][15] . The chromatographic fingerprinting for standardization of herbal formulations is an approved modern analytical technique by the USFDA and the WHO [16,17] .…”

Section: Chromatographic Fingerprinting Techniquementioning

confidence: 99%

Challenges and Prospective Solutions in Non-classical Herbal Formulations: A Review

Silpavathi¹,

Das²,

Das³

2019

ijps

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Silpavathi et al.: Challenges and Solutions of Non-classical Herbal FormulationsNon-classical herbal formulations have gained momentum in the recent past. These formulations, however, have not been well integrated with the modern system of medicine in most of the countries in the world. This is due to the lack of enough scientific evidence pertaining to its long-term safety and efficacy. Besides, the paucity of authentic monographs on the impurity profiling, standardization protocols, lack of guideline on the fixed-dose combinations and absence of programmed pharmacovigilance plan for herbal drugs are among the major caveats. In recent years, few issues pertaining to the classical herbal formulations are being addressed to some extent. However, the issues on non-classical modern formulations remain the same. Hence, the objective of this mini-review is to shed light on the major flaws and challenges of these formulations and provide some expert opinion to counter these issues.

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Evaluation of herb-drug interaction of a polyherbal Ayurvedic formulation through high throughput cytochrome P450 enzyme inhibition assay

Cited by 25 publications

References 21 publications

A Comprehensive Review of Andrographis paniculata (Burm. f.) Nees and Its Constituents as Potential Lead Compounds for COVID-19 Drug Discovery

A Comprehensive Review of Andrographis paniculata (Burm. f.) Nees and Its Constituents as Potential Lead Compounds for COVID-19 Drug Discovery

Impacts of Drug Interactions on Pharmacokinetics and the Brain Transporters: A Recent Review of Natural Compound-Drug Interactions in Brain Disorders

Challenges and Prospective Solutions in Non-classical Herbal Formulations: A Review

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