Evaluation of herbal methionine and Mangifera Indica against lead-induced organ toxicity in broilers

Du, Lakshmi; Adilaxmamma, K; Ag, Reddy; Vv, Rao

doi:10.4103/0971-6580.75864

Cited by 5 publications

(1 citation statement)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…S-Adenosylmethionine (SAMe) is the main methyl donor in various methyltransferase reactions [ 38 ] and is produced in the body from methionine [ 39 , 40 ]. Methionine is the active component of herbal methionine (a combination of herbs Cicer arietinum , Triticum sativum , Phaseolus mungo , Mucuna pruriens , and Allium cepa ) that is used in Ayurveda and herbalism [ 41 ]. Amongst these herbs, Mucuna pruriens is an antioxidant used in Ayurvedic medicine to treat Parkinson's disease [ 42 ].…”

Section: Presentation Of the Hypothesismentioning

confidence: 99%

Epigenetic Mechanisms of Integrative Medicine

Kanherkar

Stair

Bhatia‐Dey

et al. 2017

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Since time immemorial humans have utilized natural products and therapies for their healing properties. Even now, in the age of genomics and on the cusp of regenerative medicine, the use of complementary and alternative medicine (CAM) approaches represents a popular branch of health care. Furthermore, there is a trend towards a unified medical philosophy referred to as Integrative Medicine (IM) that represents the convergence of CAM and conventional medicine. The IM model not only considers the holistic perspective of the physiological components of the individual, but also includes psychological and mind-body aspects. Justification for and validation of such a whole-systems approach is in part dependent upon identification of the functional pathways governing healing, and new data is revealing relationships between therapies and biochemical effects that have long defied explanation. We review this data and propose a unifying theme: IM's ability to affect healing is due at least in part to epigenetic mechanisms. This hypothesis is based on a mounting body of evidence that demonstrates a correlation between the physical and mental effects of IM and modulation of gene expression and epigenetic state. Emphasis on mapping, deciphering, and optimizing these effects will facilitate therapeutic delivery and create further benefits.

show abstract

Section: Presentation Of the Hypothesismentioning

confidence: 99%

Epigenetic Mechanisms of Integrative Medicine

Kanherkar

Stair

Bhatia‐Dey

et al. 2017

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

Evaluation of Dietary Palygorskite Supplementation on Growth Performance, Mineral Accumulations, Antioxidant Capacities, and Meat Quality of Broilers Fed Lead-Contaminated Diet

Cheng

Chen

Cui

et al. 2017

Biol Trace Elem Res

View full text Add to dashboard Cite

The objective of this study was to evaluate influence of dietary palygorskite (Pal) supplementation on growth performance, mineral accumulations in the tissues (livers, kidneys, and muscles), antioxidant capacities, and meat quality of broilers fed lead (Pb)-contaminated diet. One-hundred forty-four male broiler chicks were randomly divided into three treatment groups, receiving a corn-soybean meal basal diet (the control group), the basal diet contaminated with 10 mg/kg Pb (the Pb group), and the basal diet with 10-g/kg Pal supplementation and 10-mg/kg Pb contamination (the Pal/Pb group) from 1 to 42 days of age, respectively. Treatments did not affect growth performance of broilers in the 42-day study (P > 0.05). Compared with the control group, Pb contamination increased Pb accumulation in the livers, kidneys, and muscles (P < 0.05); elevated malondialdehyde accumulation in the livers, kidneys, and breast muscles; glutathione peroxidase activity in the livers and superoxide dismutase activity in the kidneys (P < 0.05); exacerbated drip loss in the pectoralis muscles (P < 0.05); and reduced glutathione peroxidase activity in the pectoralis muscles (P < 0.05) of broilers at 42 days of age. The values of these parameters were reversed in the Pal/Pb group to levels comparable with those in the control group (P < 0.05). Additionally, Pal supplementation reduced redness value in the pectoralis muscles (P < 0.05), and decreased Cu concentration in the pectoralis muscles and livers at 42 days of age as well as its accumulation in the kidneys at both 21 and 42 days of age compared with the other two groups (P < 0.05). The results suggested that dietary Pal supplementation would decrease Pb residue in the tissues, alleviate oxidative stress, and affect meat quality of broilers exposed to Pb.

show abstract

Hepatoprotective role of Nicotiana plumbaginifolia Linn. against carbon tetrachloride-induced injuries

et al. 2013

View full text Add to dashboard Cite

Nicotiana plumbignifolia (Linn) is used as folk medicine in the treatment of liver dysfunction in Pakistan. The present study was designed to investigate the hepatoprotective role of N. plumbignifolia methanolice extract (NPME) against carbon tetrachloride (CCl4)-induced oxidative damage in liver of chicks. Methanolic extract of N. plumbignifolia was obtained and was further evaluated as a hepatoprotective agent against CCl4-induced oxidative damage in liver of chicks. For this study, 60-day-old 50 male chicks were divided into five groups. Chicks of group 1 (control) had free access to food and water. Group II received 1 mL/kg of CCl4 (30% in olive oil v/v) via the intraperitoneal route thrice a week for 4 weeks. Group III received 100 mg/kg body weight (b.w.) of silymarin via gavage after 48 h of CCl4 treatment, whereas group IV were given 200 mg/kg b.w. NPME after 48 h of CCl4 treatment. Hepatoprotective activity was assessed by measuring the activities of the antioxidant enzymes: catalase, peroxidase, superoxide dismutase, glutathione peroxidase, glutathione reductase, and lipid peroxidation (thiobarbituric acid reactive substances (TBARS)). Serum was analyzed for various biochemical parameters. The results revealed that CCl4 induced oxidative stress as evidenced by the significant decrease in the activity levels of antioxidant enzymes, while an increase in the levels of TBARS in liver samples is compared with the control group. Serum levels lactate dehydrogenase, triglycerides, total cholesterol, and low-density lipoprotein was elevated while reducing high-density lipoprotein compared to controls. Cotreatment of NPME treatment reversed these alterations, which seems likely that NPME can protect the liver tissues against CCl4-mediated oxidative damage.

show abstract

Evaluation of herbal methionine and Mangifera Indica against lead-induced organ toxicity in broilers

Cited by 5 publications

References 14 publications

Epigenetic Mechanisms of Integrative Medicine

Epigenetic Mechanisms of Integrative Medicine

Evaluation of Dietary Palygorskite Supplementation on Growth Performance, Mineral Accumulations, Antioxidant Capacities, and Meat Quality of Broilers Fed Lead-Contaminated Diet

Hepatoprotective role of Nicotiana plumbaginifolia Linn. against carbon tetrachloride-induced injuries

Contact Info

Product

Resources

About