Evaluation of Homonia riparia Lour. for Antiurolithiatic Activity in Albino Rats

Abstract

Ethanol extract of the roots of Homonia riparia was tested for its antiurolithiatic activity against calcium oxalate and magnesium ammonium phosphate stones in male albino rats. Calcium oxalate stones were induced by feeding 3% glycolic acid along with normal feed and magnesium ammonium phosphate stones were induced by implantation of zinc discs in the urinary bladder. The ethanol extract of H. riparia (2 g/kg/day, orally) was found to be effective in reducing deposition of calcium in the kidney of both prophylactic and curative group animals. The extract did not show any significant effect on the activity of the liver enzyme glycolic acid oxidase and on the deposition of oxalate in the kidney. The extract was found to be effective in reducing the formation and also in dissolving the pre-formed magnesium ammonium phosphate type of stones.

Antilithiatic effect of flowers ofJasminum AuriculatumVahl

“…[16] Urinary supersaturation with respect to stone-forming constituents is generally considered to be one of the causative factors in calculogenesis. Evidences in previous studies indicated that in response to 14 days period of ethylene glycol (0.75%, v/v) administration, young male albino rats form renal calculi composed mainly of calcium oxalate [6,17,18] .…”

Pharmacognostical Standardisation and HPTLC Quantification of Gallic acid in Homonoia riparia Lour

“…Traditionally, root of the plant is used in India as a laxative, emetic, diuretic, to treat urinary calculi, syphilis, gonorrhoea, malaria, antiseptic, inflammation, ulcers, urinary discharges, urinary infection, hepatitis and fungal infections. [2][3][4] Six new cycloartane type triterepenes and quercetin glycoside have been isolated from the leaves of Homonoia riparia. β-sitosterol, stigmasterol, taraxerone, taxerol, lupenol, gallic acid, β-acetyl aleuritolic acid have been isolated from the heart wood and bark of Homonoia riparia.…”

Untitled

“…This model is the most widely used model and has been more extensively reported in the scientific literature. This model represents the process of magnesium ammonium phosphate crystal growth [13][14][15] . Ethylene glycol is orally administered after implantation for the development of calcium oxalate stone 12 .…”