ObjectivesChemical, biological, radiological, and nuclear (CBRN) incidents are those that involve chemical or biological warfare agents or toxic radiological or nuclear materials. These agents can cause disasters intentionally or accidentally. Hospitals play a crucial role in handling CBRN disasters. This study aimed to assess the CBRN preparedness of government hospitals in Riyadh.MethodsA descriptive cross-sectional study was conducted across government hospitals in Riyadh, all government hospitals in Riyadh with more than 100 inpatient beds and an emergency department met the inclusion criteria. Hospital preparedness was assessed using an adaptation of the CBRNE Plan Checklist. Results were described in frequencies across several domains such as foundational considerations, planning, training and awareness, procedures, and modules for preparing for a biological incident, a chemical incident, and a radiological or nuclear incident.ResultsOf the 11 eligible hospitals, 10 participated in the study. Further, CBRN considerations were included in the disaster plans of 7 hospitals. Drills had been conducted in collaboration with local agencies in only 2 hospitals. The staff had been trained to recognize the signs and symptoms of exposure to class (A) biological agents in less than half of the hospitals. A majority of the hospitals had antidotes and prophylactics to manage chemical incidents, but only half of them had radiation detection instruments. Personal protective equipment was available in all hospitals, but rapid access to stockpiles of medications was available in only half of them.ConclusionGovernment hospitals in Riyadh demonstrated insufficient CBRN preparedness. Therefore, their staffs should be trained to manage CBRN emergencies, and local drills should be conducted to improve their preparedness.