2022
DOI: 10.3892/br.2022.1592
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Evaluation of human β‑defensins in the cerebrospinal fluid of suspected meningitis

Abstract: Human β-defensins (HBDs) are an important class of antimicrobial peptides that have immunomodulatory functions; however, the role of HBDs have not been well explored in the pathogenesis of meningitis. A cross-sectional study was performed to explore the levels of HBD1, HBD2, HBD3, and HBD4 in the cerebrospinal fluid (CSF) of 176 suspected meningitis cases. CSF samples were first subjected to PCR analysis using a set of universal primers targeting a portion of the eubacteria 16S rRNA gene. The analysis demonstr… Show more

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“…Additionally, matrix differences between patient sera (hemolysis, icterus, and lipemia) and calibrators present challenges. AMPs can also be detected using molecular research platforms, including polymerase chain reaction (PCR), microarray analysis, and next-generation sequencing (NGS) [ [22] , [23] , [24] ]. Potential disadvantages of molecular biological detection methods, such as PCR and RT-PCR, include limited sensitivity for detecting low levels of AMPs in complex samples.…”
Section: Introductionmentioning
confidence: 99%
“…Additionally, matrix differences between patient sera (hemolysis, icterus, and lipemia) and calibrators present challenges. AMPs can also be detected using molecular research platforms, including polymerase chain reaction (PCR), microarray analysis, and next-generation sequencing (NGS) [ [22] , [23] , [24] ]. Potential disadvantages of molecular biological detection methods, such as PCR and RT-PCR, include limited sensitivity for detecting low levels of AMPs in complex samples.…”
Section: Introductionmentioning
confidence: 99%