Evaluation of Hydroxyapatite as Adsorbent in the Analysis of Trace Tetracyclines in Complex Matrices

Qian, Zhou; Wang, Hong; Zhu, Kuanzheng; Yao, Cong; Jin, Peng; Chen, Yanming; Zhou, Shengyin; Zhu, Lihua

doi:10.1007/s12161-020-01858-5

Cited by 3 publications

(2 citation statements)

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“…It is speculated that TC is combined with HAp in the bone [29]. In addition, TC, OTC, and CTC can adsorb HAp [30][31][32][33]. Therefore, TCs are promising targeting ligands.…”

Section: Introductionmentioning

confidence: 99%

“…Numerous functional groups exist on the surface of TCs and are unstable during chemical modifications [35], limiting the development of TCs as a drug delivery system for bonetargeting ligands. Although the effective adsorption capacity of TCs on HAp has been extensively studied in experiments [29][30][31][32][33]36,37], understanding of the specific interaction mechanism between HAp and TCs is limited. The adsorption process of TCs (TC, OTC, and CTC) with different properties on HAp must be further studied.…”

Section: Introductionmentioning

confidence: 99%

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Sorption Studies of Tetracycline Antibiotics on Hydroxyapatite (001) Surface—A First-Principles Insight

et al. 2022

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Owing to the limitations of traditional systemic drug delivery in the treatment of bone diseases with side effects on normal cells, the selection of materials with high affinities for bones, as targeting ligands to modify drug carriers, has become an important research topic. Tetracyclines (TCs) have an adsorption effect on hydroxyapatite (HAp). Thus, they can be used as bone-targeting ligands and combined with drug carriers. In this study, density functional theory is used to analyze the interaction mechanism of TC, oxytetracycline (OTC), chlortetracycline, and HAp. We calculate the electrostatic potential (ESP) and molecular orbitals to predict the possible binding sites of TCs on the HAp surface. The adsorption energy is used to compare the affinities of the three TCs to HAp. An independent gradient model analysis is performed to study the weak interaction between TCs and HAp. The coordination bond between TCs and the HAp surface is evaluated by conducting a charge density difference analysis. The results show that OTC has the highest affinity to HAp because the introduction of hydroxyl groups change the adsorption configuration of OTC. Thus, OTC adsorbed on HAp in a broken-line shape exposes more binding sites. This study provides a theoretical basis for TCs as bone-targeting ligands in treating bone diseases and in improving the safety of treatment by selecting different bone-targeting ligands.

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“…It is speculated that TC is combined with HAp in the bone [29]. In addition, TC, OTC, and CTC can adsorb HAp [30][31][32][33]. Therefore, TCs are promising targeting ligands.…”

Section: Introductionmentioning

confidence: 99%