Evaluation of hydroxylated metabolites of polycyclic aromatic hydrocarbons and biomarkers of early kidney damage in indigenous children from Ticul, Yucatán, Mexico

León-Martínez, Lorena Díaz de; Ortega-Romero, Manolo; Barbier, Olivier; Pérez-Herrera, Norma; May-Euán, Fernando; Perera-Ríos, Javier; Rodríguez-Aguilar, Maribel; Flores-Ramírez, Rogelio

doi:10.1007/s11356-021-14460-x

Cited by 10 publications

(4 citation statements)

References 71 publications

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“…However, as previously stated, our study may have still been limited by reverse causation due to the population already having diminished kidney function. Still, this design allowed us to obtain measurements of PAHs over time, which is important given their nonpersistence 19 and in contrast to other studies that have investigated impacts on renal function using just one spot urine measurement of PAHs [15][16][17][18] . This study represents the first exploration of serially measured PAHs in relation to kidney function and allowed for a careful examination of these biomarkers over time.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, two other cross-sectional studies using NHANES data found associations between urinary PAH metabolites and decreased eGFR (15) and increased albuminuria (16). Two other cross-sectional studies among highly exposed indigenous populations in Mexico reported conflicting results: one found positive associations between PAH metabolites and kidney injury biomarkers, including neutrophil gelatinase-associated lipocalin (NGAL) (17), whereas the other found no such correlation (18). To our knowledge, no longitudinal studies have been conducted on PAH exposure in relation to renal function.…”

Section: Introductionmentioning

confidence: 99%

“…16 Two other cross-sectional studies among highly exposed indigenous populations in Mexico reported conflicting results: one found positive associations between PAH metabolites and kidney injury biomarkers including neutrophil gelatinase-associated lipocalin (NGAL) 17 whereas the other found no such correlation. 18 To our knowledge, no longitudinal studies have been conducted on PAH exposure in relation to renal function. This is particularly important for two reasons.…”

Section: Introductionmentioning

confidence: 99%

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Urinary Polycyclic Aromatic Hydrocarbons in a Longitudinal Cohort of Children with CKD: A Case of Reverse Causation?

Jacobson¹,

Wu²,

Liu³

et al. 2022

Kidney360

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Background: Air pollution, which results in the formation of polycyclic aromatic hydrocarbons (PAH), has been identified as a cause of renal function decline and a contributor to chronic kidney disease (CKD). However, the results of cross-sectional studies investigating personal, integrated biomarkers of PAHs have been mixed. Longitudinal studies may be better suited to evaluate environmental drivers of kidney decline. The purpose of this study was to examine associations of serially measured urinary PAH metabolites with clinical and subclinical measures of kidney function over time among children with CKD. Methods: This study was conducted among 618 participants in the CKD in Children study, a cohort study of pediatric CKD patients from the US and Canada, between 2005 and 2015. In serially collected urine samples over time, nine PAH metabolites were measured. Clinical outcomes measured annually included estimated glomerular filtration rate (eGFR), proteinuria, and blood pressure. Subclinical biomarkers of tubular injury (kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL)) and oxidant stress (8-hydroxy-2'- deoxyguanosine (8-OHdG) and F2-isoprostane) were assayed in urine samples. Results: Children were followed over an average of 3.0 years (standard deviation (SD)=1.6) and 2469 study visits (mean=4.0, SD=1.6). Hydroxynaphthalene (NAP) or hydroxyphenanthrene (PHEN) metabolites were detected in >99% of samples and NAP concentrations were greater than PHEN concentrations. PHEN metabolites, driven by 3-PHEN, were associated with increased eGFR and reduced proteinuria, diastolic blood pressure z-score, and NGAL concentrations over time. However, PAH metabolites were consistently associated with increased KIM-1 and 8-OHdG concentrations. Conclusions: Among children with CKD, these findings provoke the potential explanation of reverse causation where renal function affects measured biomarker concentrations even in the setting of a longitudinal study. Additional work is needed to determine if elevated KIM-1 and 8-OHdG excretion reflects site-specific injury to the proximal tubule mediated by low-grade oxidant stress.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Urinary Polycyclic Aromatic Hydrocarbons in a Longitudinal Cohort of Children with CKD: A Case of Reverse Causation?

Jacobson¹,

Wu²,

Liu³

et al. 2022

Kidney360

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“…El segundo grupo de problemas de salud son aquellos ligados a la presencia de contaminantes ambientales en el entorno domiciliar. Se ha documentado la presencia de plaguicidas, metales, hidrocarburos y otras sustancias tóxicas en animales sinantrópicos, agua y en seres humanos, ligando su exposición a los quehaceres cotidianos, los cuales muchas veces se dan en el contexto de las actividades productivas como talleres, manufacturas, artesanías, o por manejo inadecuado de plaguicidas o agroquímicos desarrollados en el huerto familiar o el peridomicilio; representando un importante riesgo para la salud pública y para la sostenibilidad ambiental (Ramírez-Hernández et al, 2018;Pérez-Herrera et al, 2019;Escamilla-López, Ruiz-Piña and Rendón-von Osten, 2020;Díaz de León-Martínez et al, 2021;Perera-Rios et al, 2021).…”

Section: Las Zoonosis Y El Peridomiciliounclassified

El Peridomicilio Y Las Zoonosis en Yucatán. Hacia La Búsqueda De Una Salud

Reyes‐Novelo¹,

Ruiz‐Piña²,

Canché-Pool³

et al. 2021

Trop Subtrop Agroecosyst

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Background: People's peridomicile and home gardens represent a critical bridge for circulating endemic, emerging, and reemerging zoonotic pathogens in the Yucatan region. Objective: to analyze the information on zoonotic diseases documented in the premise and family gardens environment in the Yucatan region and propose an approximation for their prevention and control focusing on a One Health approach. Implications: Proposals based on One Health approach requires the horizontal involvement of social actors, because vertical or government based decisions are not enough to reach health objectives Conclusion: the access to actions based on a One Health approach can directly impact the prevention and control of zoonotic diseases and other environmental health problems.

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Environmental contamination with polycyclic aromatic hydrocarbons and contribution from biomonitoring studies to the surveillance of global health

Teixeira,

Delerue-Matos,

Morais

et al. 2024

Environ Sci Pollut Res

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This work presents an integrated overview of polycyclic aromatic hydrocarbons’ (PAHs) ubiquity comprising environmental contamination in the air, aquatic ecosystems, and soils; characterizes the contamination in biota; and identifies main biomonitors and human exposure to PAHs and associated health risks. Urban centers and industrial areas present increased concentrations in the air (1344.4–12,300 versus 0.03–0.60 ng/m3 in industrial/urban and rural zones) and soils (0.14–1.77 × 106 versus 2.00–9.04 × 103 versus 1.59–5.87 × 103 ng/g in urban, forest, and rural soils), respectively. Increased concentrations were found in coastal zones and superficial waters as well as in sediments (7.00 × 104–1.00 × 109 ng/g). Benzo(a)pyrene, a carcinogenic PAH, was found in all environmental media. Mosses, lichens, tree leaves, bivalves, cephalopods, terrestrials’ snails, and honeybees are good biomonitors of biota contamination. More studies are needed to improve characterization of PAHs’ levels, distribution, and bioaccumulation in the environmental media and assess the associated risks for biota and human health. Actions and strategies to mitigate and prevent the bioaccumulation of PAHs in the environment and trophic chains toward the WHO’s One-Health Perspective to promote the health of all ecosystems and human life are urgently needed.

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Evaluation of hydroxylated metabolites of polycyclic aromatic hydrocarbons and biomarkers of early kidney damage in indigenous children from Ticul, Yucatán, Mexico

Cited by 10 publications

References 71 publications

Urinary Polycyclic Aromatic Hydrocarbons in a Longitudinal Cohort of Children with CKD: A Case of Reverse Causation?

Urinary Polycyclic Aromatic Hydrocarbons in a Longitudinal Cohort of Children with CKD: A Case of Reverse Causation?

El Peridomicilio Y Las Zoonosis en Yucatán. Hacia La Búsqueda De Una Salud

Environmental contamination with polycyclic aromatic hydrocarbons and contribution from biomonitoring studies to the surveillance of global health

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