Evaluation of hypoglycemic activity of the polysaccharides extracted from <i>Lycium barbarum</i>

Abstract

A study was undertaken to evaluate the hypoglycemic activity of polysaccharide extracted from Lycium barbarum (LBP). The various parameters studied included body weight (bw), fasting blood glucose levels (FBG), total cholesterol (TC) and triglyceride (TG) in diabetic and normal mice. LBP treatment (20, 40 mg/ kg body weight) for 28 days resulted in a significant decrease in the concentration of FBG, TC and TG in diabetes mellitus mice. Furthermore, LBP significantly increased body weight. The data demonstrated LBP at the dose of 40 mg/kg bw exhibited the better effect.

A review of botanical characteristics, phytochemistry, clinical relevance in efficacy and safety of Lycium barbarum fruit (Goji)

“…Pretreatment with L-arginine partially restored acetylcholine-induced relaxation in hypertensive rats, but no effect in LBP-treated rats. LBP treatment resulted in a significant decrease in the concentration of fasting blood glucose levels, total cholesterol and triglyceride in diabetes mellitus mice (Jing, Cui, Feng, & Xiao, 2009).…”

“…The decreased activation of extracellular signal-regulated kinases 1 and 2 in mesangial cells, through the involvement of protein kinase C, may explain the protective mechanism in kidneys of diabetic rats treated with LBP (Zhao, Li, Li, & Zhang, 2009). LBP treatment also resulted in a significant decrease in the concentration of fasting blood glucose levels, total cholesterol and triglyceride in diabetes mellitus mice (Jing et al, 2009).…”

Goji Berry (Lycium Barbarum) in the treatment of diabetes melitus: a systematic review

“…Another positive finding regarding the use of Goji berry was found by Jing et al (2009). According to the authors, the use of LBP-4 in diabetic rats showed a decrease in total cholesterol and triglycerides levels.…”

A Review on Anti-diabetic Plants

“…84 Hyoscyamys albus: Calystegines (A 3 , A 5 , A 5 glycosides, B 1 , B 2 , B 4 , N 1 ) that was isolated from H. albus seeds are potent anti-diabetic agents with antihyperglycemic and hypolipidemic effects, and a protective function on pancreas in streptozotocin induced diabetes. 85 …”