Evaluation of Hypoglycemic Property of Gurmar (Gymnema Sylvestre) Leaves Methanolic Extract (GSLME) in Streptozocin (STZ) induced Diabetic Albino Rats

Sk, Ahmed

doi:10.18535/jmscr/v5i12.78

Cited by 6 publications

(3 citation statements)

References 14 publications

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“…Several studies have reported the anti‐diabetic potential of phytomolecules, such as phenolic compounds, flavonoids, saponins, alkaloids, polysaccharides, amino acids, proteins, and coumarins from T. foenum‐graecum (Laila et al, 2023 ). Published studies also reported the anti‐diabetic potential of G. sylvestre as the administration of this plant in diabetic‐induced animals resulted in the reduction of blood glucose level, cholesterol, triglycerides, and proteins while increase in HDL‐cholesterol level and insulin (Ahmed et al, 2017 ; Kumar et al, 2017 ). Therefore, in this study, the effect of T. foenum‐graecum , G. sylvestre and their combination along with metformin was studied in alloxan‐induced diabetic rabbits.…”

Section: Discussionmentioning

confidence: 98%

Unlocking the anti‐diabetic potential of Gymnema sylvestre, Trigonella foenum‐graecum, and their combination thereof: An in‐vivo evaluation

Kashif,

Nasir,

Gulzaman

et al. 2023

Food Science & Nutrition

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The current study aimed to explore the anti‐diabetic effect of aqueous extracts of Gymnema sylvestre, Trigonella foenum‐graecum and mixture of both the plants in alloxan‐induced diabetic rabbits. A total of 30 rabbits were grouped into six equal groups as: normal control, diabetic control, diabetic treated with 300 mg/kg body weight (bw) G. sylvestre, diabetic treated with 300 mg/kg bw T. foenum‐graecum, diabetic treated with 300 mg/kg bw mixture of both the plants and diabetic treated with 500 mg/kg bw metformin for 4 weeks. Diabetes was induced to all the study group animals except normal control by intravenous administration of alloxan monohydrate (80 mg/kg bw). Blood glucose was measured by glucometer and other biochemical parameters were determined through various kit methods. Serum insulin was measured through ELISA kit method. Results showed that both the plants and metformin significantly (p < .05) decreased the fasting blood glucose. Hypoglycemic activity of aqueous extract of G. sylvestre and metformin was found slightly higher than aqueous extract of T. foenum‐graecum and the mixture of both the plants. However, a significant (p < .05) rise in insulin secretion was observed in studied plants extract treated rabbits. Serum urea, creatinine, and liver enzymes were found reduced significantly (p < .05) in treated rabbits whereas packed cell volume was also returned to normal in treated animals as compared to control group. The study concluded that G. sylvestre and T. foenum‐graecum extracts have comparable effects with metformin in normalizing the blood glucose level and have more pronounced effect than metformin in restoring the serum biochemical parameters to normal levels. Hence, these plants may be the good alternative medicine in managing the diabetes mellitus.

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Section: Discussionmentioning

confidence: 98%

Unlocking the anti‐diabetic potential of Gymnema sylvestre, Trigonella foenum‐graecum, and their combination thereof: An in‐vivo evaluation

Kashif,

Nasir,

Gulzaman

et al. 2023

Food Science & Nutrition

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“…Gymnema sylvestre reduced the level of blood glucose levels after both acute and chronic administration of methanolic extract of this plant on Wister rats (Dholi and Raparla, 2014). In the case of Streptozotocin-induced diabetic rats, it has been shown that treatment using this plant significantly ( p < 0.05) decreased the elevated blood glucose, ALT, AST, triglycerides, total cholesterol, LDL-cholesterol, and malondialdehyde, and significantly ( p < 0.05) increased insulin, HDL-cholesterol, and erythrocyte superoxide dismutase levels in diabetic rats and also is capable of regenerating insulin producing β-cells (Aralelimath and Bhise, 2012; Shafey et al, 2013; Kumar et al, 2017; Ahmed et al, 2017). Gymnemic acids (a type of triterpene saponin compounds) are the class of active constituents isolated form Gymnema sylvestre .…”

Section: In Vitro and In Vivo Pharmacological Activity Reports On Gymmentioning

confidence: 99%

Comprehensive Review on Phytochemicals, Pharmacological and Clinical Potentials of Gymnema sylvestre

et al. 2019

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Gymnema sylvestre is a plant included in Apocynaceae family and is located in many regions of Asia, Africa and Australia. This plant is widely used as a traditional therapy for different purposes. Even now it is being used as a dietary supplement due to its numerous therapeutic uses. It is known to have blood glucose lowering potential and, thus, is widely used in traditional and Ayurvedic systems of medicine. It renders glucose lowering activity due to the presence of phytochemicals, such as gurmarin, gymnemic acid as well as gymnemasaponins. Gymnema sylvestre is also known to have anti-oxidant, antibiotic, anti-inflammatory, antiviral, gastro and hepatoprotective, anticancer and lipid-lowering activities. This review discusses in details on different pharmacological and clinical potentials of Gymnema sylvestre and its chemical constituents associated with its therapeutic potentials.

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“…Diabetes mellitus (DM), a metabolic disorder pronounced by a rise in the concentration of glucose in the blood because of absolute (type 1) or proportionate (type 2) lack of insulin leading to hyper-glycemia. This is associated with the aberrant metabolism of protein, fat and carbohydrates (Sk, 2017). DM is one amongst the most important world health emergencies of the twenty-irst century.…”

Section: Introductionmentioning

confidence: 99%

Gymnemic acid, a potent antidiabetic agent protects skeletal muscle from hyperglycemia mediated oxidative stress and apoptotic events in High fat and High fructose diet fed adult rats

Karthikeyan

Chakrapani

Mohan

et al. 2020

ijrps

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Type 2 diabetes is delineated by impaired metabolic lexibility, and intramyocellular lipid accumulation, causing insulin resistance, particularly in skeletal muscle by reducing insulin-stimulated glucose uptake. High-fat diet and high fructose (HFD and HF) administration in rodents bestows a model for hyperlipidemia, insulin resistance, and Type 2 diabetes. The current study is focused on elucidating the role of Gymnemic acid in combating hyperglycemia mediated oxidative stress and apoptotic events in the skeletal muscle of HFD and HF induced Type 2 diabetes in Wistar albino rats by boosting antioxidant defense system. Gymnemic acid, a saponin of triterpene glycoside contained in leaves of Gymnema Sylvestre, has potent anti-diabetic properties. Treatment with Gymnemic acid restored the antioxidant status (Gpx, SOD, CAT, GR, Vit C & Vit E) with signi icant (p<0.05) decrease in free radical levels and reinvigorated the expression of apoptotic and antiapoptotic proteins in Type 2 diabetic rats. Histopathological data demonstrate that oral administration of Gymnemic acid protects skeletal muscle ibers from an oxidative niche in HFD and HF in Type 2 diabetic rats. In accordance with this, Gymnemic acid might be regarded as a promising therapeutic agent against Type 2 diabetes, thereby restoring skeletal muscle integrity and function.

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Evaluation of Hypoglycemic Property of Gurmar (Gymnema Sylvestre) Leaves Methanolic Extract (GSLME) in Streptozocin (STZ) induced Diabetic Albino Rats

Cited by 6 publications

References 14 publications

Unlocking the anti‐diabetic potential of Gymnema sylvestre, Trigonella foenum‐graecum, and their combination thereof: An in‐vivo evaluation

Unlocking the anti‐diabetic potential of Gymnema sylvestre, Trigonella foenum‐graecum, and their combination thereof: An in‐vivo evaluation

Comprehensive Review on Phytochemicals, Pharmacological and Clinical Potentials of Gymnema sylvestre

Gymnemic acid, a potent antidiabetic agent protects skeletal muscle from hyperglycemia mediated oxidative stress and apoptotic events in High fat and High fructose diet fed adult rats

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